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23 - Can a systems biologist fix a Tamagotchi?

Published online by Cambridge University Press:  06 August 2010

Luca Cardelli
Affiliation:
Microsoft Research
Yves Bertot
Affiliation:
INRIA-Sophia Antipolis, France
Gérard Huet
Affiliation:
Institut National de Recherche en Informatique et en Automatique (INRIA), Rocquencourt
Jean-Jacques Lévy
Affiliation:
Institut National de Recherche en Informatique et en Automatique (INRIA), Rocquencourt
Gordon Plotkin
Affiliation:
University of Edinburgh
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Summary

Abstract

Gilles Kahn was a serious scientist, but part of his style and effectiveness was in the great sense of curiosity and fun that he injected in the most technical topics. Some of his later projects involved connecting computing and the traditional sciences. I offer a perspective on the culture shock between biology and computing, in the style in which I would have explained it to him.

The nature of nature

In a now classic peer-reviewed commentary, “Can a Biologist Fix a Radio?”, Yuri Lazebnik describes the serious difficulties that scientists have in understanding biological systems. As an analogy, he describes the approach biologists would take if they had to study radios, instead of biological organisms, without having prior knowledge of electronics.

We would eventually find how to open the radios and will find objects of various shape, color, and size […]. We would describe and classify them into families according to their appearance. We would describe a family of square metal objects, a family of round brightly colored objects with two legs, round-shaped objects with three legs and so on. Because the objects would vary in color, we will investigate whether changing the colors affects the radio's performance. Although changing the colors would have only attenuating effects (the music is still playing but a trained ear of some people can discern some distortion), this approach will produce many publications and result in a lively debate.

Type
Chapter
Information
From Semantics to Computer Science
Essays in Honour of Gilles Kahn
, pp. 517 - 528
Publisher: Cambridge University Press
Print publication year: 2009

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References

[1] Debugging advice can be found at http://www.wikihow.com/Debug-a-Tamagotchi.
[2] Y., Lazebnik. Can a biologist fix a radio? Or, what I learned while studying apoptosis. Cancer Cell 2:179–182, 2002.Google Scholar
[3]E., Klipp, R., Herwig, A., Kowald, C., Wierling and H., Lehrach. Systems Biology in Practice. Wiley, 2005.Google Scholar
[4]R., Feynman, R., Leighton and E., Hutchings. He fixes radios by thinking. In Surely You're Joking, Mr. Feynman!: Adventures of a Curious Character. W.W. Norton, 1985.Google Scholar
[5],Bandai. Tamagotchi Connection. http://www.tamagotchi.com
[6]P., Tonella and A., Potrich. Reverse Engineering of Object-Oriented Code. Springer, 2005.Google Scholar
[7]S., Brenner. Interview. Discover Magazine 25(4), 2004.Google Scholar
[8]C.-H., Yuh, H., Bolouri and E. H., Davidson. Genomic cis-regulatory logic: experimental and computational analysis of a sea urchin. Gene. Science, 279:1896–1902, 1998.Google Scholar
[9]A., Wagner. How to reconstruct a large genetic network from n gene perturbations in fewer than n easy steps. Bioinformatics, 17(12):1183–1197, 2001.Google Scholar

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