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7 - Infections and immunity

Published online by Cambridge University Press:  01 June 2011

James C. Barton ,
Corwin Q. Edwards ,
Pradyumna D. Phatak ,
Robert S. Britton  and
Bruce R. Bacon
By
James C. Barton ,
Corwin Q. Edwards ,
Pradyumna D. Phatak ,
Robert S. Britton  and
Bruce R. Bacon
James C. Barton
Affiliation:
University of Alabama, Birmingham
Corwin Q. Edwards
Affiliation:
University of Utah Medical Center
Pradyumna D. Phatak
Affiliation:
University of Rochester Medical Center, New York
Robert S. Britton
Affiliation:
St Louis University, Missouri
Bruce R. Bacon
Affiliation:
St Louis University, Missouri
James C. Barton
Affiliation:
University of Alabama, Birmingham
Corwin Q. Edwards
Affiliation:
University of Utah School of Medicine, Salt Lake City
Pradyumna D. Phatak
Affiliation:
University of Rochester Medical Center, New York
Robert S. Britton
Affiliation:
St Louis University, Missouri
Bruce R. Bacon
Affiliation:
St Louis University, Missouri
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Summary

Persons with hemochromatosis or other iron overload conditions are susceptible to infection by some organisms that rarely cause illness in people with normal body iron stores (Table 7.1). Bacteria require iron for their own metabolism. Hosts with iron overload may thus have increased susceptibility to infection with certain bacteria. Vibrio vulnificus and Yersinia species are well-known causes of life-threatening infections in persons with iron overload. Listeria monocytogenes and organisms associated with zygomycosis sometimes cause severe infections in persons who have hemochromatosis, other types of liver disease, diabetes mellitus, immunodeficiency, or skin wounds. Infections with Escherichia coli are common in persons without iron overload, although unusually severe E. coli infections have been reported in some patients who had hemochromatosis or iron overload. Infections with these organisms also occur in patients without iron overload, many of whom have non-iron conditions that may increase their susceptibility to infection. Some persons with hemochromatosis or iron overload have abnormal phagocyte function, low levels of one or more blood lymphocyte subsets, or selective deficiency of immunoglobulin isotypes.

Vibrio vulnificus infections

Epidemiology

V. vulnificus is a motile, halophilic, free-living Gram-negative bacillus that grows as normal marine flora and is distributed worldwide in warm, coastal waters. It can cause very serious infections in persons with iron overload, cirrhosis, or decreased immunity. V. vulnificus causes three major categories of infections: (1) primary septicemia occurs due to ingestion of uncooked oysters or other raw shellfish (or of cooked food contaminated with seawater drippings); (2) wound infections develop after contact of superficial wounds with seawater that contains V. vulnificus; and (3) gastroenteritis, associated with raw shellfish consumption, is accompanied by vomiting, diarrhea, abdominal pain, and positive stool cultures for V. vulnificus, but blood cultures are negative and there is no associated wound.

Type
Chapter
Information
Handbook of Iron Overload Disorders , pp. 112 - 126
Publisher: Cambridge University Press
Print publication year: 2010

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References

Blake, PA, Merson, MH, Weaver, RE, Hollis, DG, Heublein, PC. Disease caused by a marine Vibrio. Clinical characteristics and epidemiology. N Engl J Med 1979; 300: 1.CrossRefGoogle ScholarPubMed
Bonner, JR, Coker, AS, Berryman, CR, Pollock, HM. Spectrum of Vibrio infections in a Gulf Coast community. Ann Intern Med 1983; 99: 464–9.CrossRefGoogle Scholar
McManus, R, Gordon, RS. Highly invasive new bacterium isolated from US East Coast waters. JAMA 1984; 251: 323.Google Scholar
Muench, KH. Hemochromatosis and infection: alcohol and iron, oysters and sepsis. Am J Med 1989; 87: 40N–3N.Google ScholarPubMed
Bullen, JJ, Spalding, PB, Ward, CG, Gutteridge, JM. Hemochromatosis, iron, and septicemia caused by Vibrio vulnificus. Arch Intern Med 1991; 151: 1606–9.CrossRefGoogle ScholarPubMed
Bullen, JJ. Bacterial infections in hemochromatosis. In: Barton, JC, Edwards, CQ, eds. Hemochromatosis: Genetics, Pathophysiology, Diagnosis, and Treatment. Cambridge, Cambridge University Press. 2000; 381–6.CrossRefGoogle Scholar
Gerhard, GS, Levin, KA, Price, GJ, Wojnar, MM, Chorney, MJ, Belchis, DA. Vibrio vulnificus septicemia in a patient with the hemochromatosis HFE C282Y mutation. Arch Pathol Lab Med 2001; 125: 1107–9.Google Scholar
Barton, JC, Coghlan, ME, Reymann, MT, Ozbirn, TW, Acton, RT. Vibrio vulnificus infection in a hemodialysis patient receiving intravenous iron therapy. Clin Infect Dis 2003; 37: e63–e67.CrossRefGoogle Scholar
Barton, JC, Ratard, RC. Vibrio vulnificus bacteremia associated with chronic lymphocytic leukemia, hypogammaglobulinemia, and hepatic cirrhosis: relation to host and exposure factors in 252 V. vulnificus infections reported in Louisiana. Am J Med Sci 2006; 332: 216–20.CrossRefGoogle ScholarPubMed
Byrnes, JM. Necrotizing fasciitis: a common problem in Darwin. Int J Low Extrem Wounds 2006; 5: 2716.CrossRefGoogle ScholarPubMed
Khan, FA, Fisher, MA, Khakoo, RA. Association of hemochromatosis with infectious diseases: expanding spectrum. Int J Infect Dis 2007; 11: 482.CrossRefGoogle ScholarPubMed
Ralph, A, Currie, BJ. Vibrio vulnificus and V. parahaemolyticus necrotising fasciitis in fishermen visiting an estuarine tropical northern Australian location. J Infect 2007; 54: e111–14.CrossRefGoogle ScholarPubMed
Kim, DM, Cho, HS, Kang, JI, Kim, HS, Park, CY. Deferasirox plus ciprofloxacin combination therapy after rapid diagnosis of Vibrio vulnificus sepsis using real-time polymerase chain reaction. J Infect 2008; 57: 489–92.CrossRefGoogle ScholarPubMed
Barton, JC, Acton, RT. Hemochromatosis and Vibrio vulnificus wound infections. J Clin Gastroenterol 2009; 43: 890–3.CrossRefGoogle ScholarPubMed
Robins-Browne, RM, Rabson, AR, Koornhof, HJ. Generalized infection with Yersinia enterocolitica and the role of iron. Contrib Microbiol Immunol 1979; 5: 277–82.Google Scholar
Abbott, M, Galloway, A, Cunningham, JL. Haemochromatosis presenting with a double Yersinia infection. J Infect 1986; 13: 143.CrossRefGoogle ScholarPubMed
Conway, SP, Dudley, N, Sheridan, P, Ross, H. Haemochromatosis and aldosterone deficiency presenting with Yersinia pseudotuberculosis septicaemia. Postgrad Med J 1989; 65: 174–6.CrossRefGoogle ScholarPubMed
Olesen, LL, Ejlertsen, T, Paulsen, SM, Knudsen, PR. Liver abscesses due to Yersinia enterocolitica in patients with haemochromatosis. J Intern Med 1989; 225: 351–4.CrossRefGoogle ScholarPubMed
Munoz, MT, Garcia, PJ, Collazos, GJ, Miguel, PJ. [Yersinia enterocolitica bacteremia and hemochromatosis.]Rev Clin Esp 1991; 189: 92.Google Scholar
Vadillo, M, Corbella, X, Pac, V, Fernandez-Viladrich, P, Pujol, R. Multiple liver abscesses due to Yersinia enterocolitica discloses primary hemochromatosis: three cases reports and review. Clin Infect Dis 1994; 18: 938–41.CrossRefGoogle ScholarPubMed
Collazos, J, Guerra, E, Fernandez, A, Mayo, J, Martinez, E. Miliary liver abscesses and skin infection due to Yersinia enterocolitica in a patient with unsuspected hemochromatosis. Clin Infect Dis 1995; 21: 223–4.CrossRefGoogle Scholar
Abdelli, N, Thiefin, G, Chevalier, P, Zeitoun, P. [Spontaneously regressive liver abscess caused by Yersinia enterocolitica revealing genetic hemochromatosis: a second case.]Gastroenterol Clin Biol 1996; 20: 212–13.Google Scholar
Piroth, L, Meyer, P, Bielefeld, P, Besancenot, JF. [Yersinia bacteremia and iron overload.] Rev Med Interne 1997; 18: 932–8.CrossRefGoogle ScholarPubMed
Bergmann, TK, Vinding, K, Hey, H. Multiple hepatic abscesses due to Yersinia enterocolitica infection secondary to primary haemochromatosis. Scand J Gastroenterol 2001; 36: 891.CrossRefGoogle ScholarPubMed
Hopfner, M, Nitsche, R, Rohr, A, Harms, D, Schubert, S, Folsch, UR. Yersinia enterocolitica infection with multiple liver abscesses uncovering a primary hemochromatosis. Scand J Gastroenterol 2001; 36: 220–4.CrossRefGoogle ScholarPubMed
Mennecier, D, Lapprand, M, Hernandez, E, et al. [Liver abscesses due to Yersinia pseudotuberculosis discloses a genetic hemochromatosis.]Gastroenterol Clin Biol 2001; 25: 1113–15.Google Scholar
Benbrika, S, Boukari, L, Stirnemann, J, et al. [A case of yersiniasis with multiple liver abscesses.]Rev Med Interne 2005; 26: 151–2.CrossRefGoogle Scholar
Crosbie, J, Varma, J, Mansfield, J. Yersinia enterocolitica infection in a patient with hemochromatosis masquerading as proximal colon cancer with liver metastases: report of a case. Dis Colon Rectum 2005; 48: 390–2.CrossRefGoogle Scholar
Sinkovics, JG, Cormia, F, Plager, C. Hemochromatosis and Listeria infection. Arch Intern Med 1980; 140: 284.CrossRefGoogle ScholarPubMed
Asbeck, BS, Verbrugh, HA, Oost, BA, Marx, JJ, Imhof, HW, Verhoef, J. Listeria monocytogenes meningitis and decreased phagocytosis associated with iron overload. Br Med J (Clin Res Ed) 1982; 284: 542–4.CrossRefGoogle ScholarPubMed
Mossey, RT, Sondheimer, J. Listeriosis in patients with long-term hemodialysis and transfusional iron overload. Am J Med 1985; 79: 397–400.CrossRefGoogle ScholarPubMed
Henrion, J, Neve, A, Heller, F. [Bacterial septicemia: an unrecognized complication of hemochromatosis. Study of 3 cases and review of the literature.]Acta Clin Belg 1986; 41: 10–17.CrossRefGoogle Scholar
Calubiran, OV, Horiuchi, J, Klein, NC, Cunha, BA. Listeria monocytogenes meningitis in a human immunodeficiency virus-positive patient undergoing hemodialysis. Heart Lung 1990; 19: 21–3.Google Scholar
Hoen, B, Kessler, M. [Infectious risks in patients with renal failure on hemodialysis. Importance of iron overload and deferoxamine.]Presse Med 1991; 20: 681–2.Google Scholar
Manso, C, Rivas, I, Peraire, J, Vidal, F, Richart, C. Fatal Listeria meningitis, endocarditis and pericarditis in a patient with haemochromatosis. Scand J Infect Dis 1997; 29: 308–9.CrossRefGoogle Scholar
Seeger, W, Hugo, F, Heine, C, Handrick, W. [Listeriosis in a patient with hemodialysis and iron overload.]Med Klin (Munich) 2007; 102: 483.CrossRefGoogle Scholar
Brennan, RO, Crain, BJ, Proctor, AM, Durack, DT. Cunninghamella: a newly recognized cause of rhinocerebral mucormycosis. Am J Clin Pathol 1983; 80: 98–102.CrossRefGoogle ScholarPubMed
Johnson, E, Kline, LB, Julian, BA, Garcia, JH. Bilateral cavernous sinus thrombosis due to mucormycosis. Arch Ophthalmol 1988; 106: 1089–92.CrossRefGoogle ScholarPubMed
McNab, AA, McKelvie, P. Iron overload is a risk factor for zygomycosis. Arch Ophthalmol 1997; 115: 919–21.CrossRefGoogle ScholarPubMed
MacSween, RNM. Acute abdominal crises, circulatory collapse and sudden death in haemochromatosis. Q J Med 1966; 35: 589–98.Google Scholar
Christopher, GW. Escherichia coli bacteremia, meningitis, and hemochromatosis. Arch Intern Med 1985; 145: 1908.CrossRefGoogle ScholarPubMed
Corke, PJ, McLean, AS, Stewart, D, Adams, S. Overwhelming Gram-negative septic shock in haemochromatosis. Anaesth Intensive Care 1995; 23: 346–9.Google ScholarPubMed
Christopher, GW. Escherichia coli bacteremia, meningitis, and hemochromatosis. Arch Intern Med 1985; 145: 1908.CrossRefGoogle ScholarPubMed
Corke, PJ, McLean, AS, Stewart, D, Adams, S. Overwhelming Gram-negative septic shock in haemochromatosis. Anaesth Intensive Care 1995; 23: 346–9.Google ScholarPubMed
Klontz, KC, Lieb, S, Schreiber, M, Janowski, HT, Baldy, LM, Gunn, RA. Syndromes of Vibrio vulnificus infections. Clinical and epidemiologic features in Florida cases, 1981–1987. Ann Intern Med 1988; 109: 318–23.CrossRefGoogle ScholarPubMed
Kumamoto, KS, Vukich, DJ. Clinical infections of Vibrio vulnificus: a case report and review of the literature. J Emerg Med 1998; 16: 61–6.CrossRefGoogle ScholarPubMed
Bufano, G, Ceruti, T, Ferrari, L, Pecchini, F. Listeriosis in a patient with long-term hemodialysis but without iron overload. Nephron 1995; 69: 356.CrossRefGoogle Scholar
Mead, PS, Slutsker, L, Dietz, V, et al. Food-related illness and death in the United States. Emerg Infect Dis 1999; 5: 607–25.CrossRefGoogle ScholarPubMed
Johnson, RW, Arnett, FC. A fatal case of Vibrio vulnificus presenting as septic arthritis. Arch Intern Med 2001; 161: 2616–18.CrossRefGoogle ScholarPubMed
Tsai, YH, Hsu, RW, Huang, KC, et al. Systemic Vibrio infection presenting as necrotizing fasciitis and sepsis. A series of 13 cases. J Bone Joint Surg Am 2004; 86-A: 249702.CrossRefGoogle Scholar
Dechet, AM, Yu, PA, Koram, N, Painter, J. Non-foodborne Vibrio infections: an important cause of morbidity and mortality in the United States, 1997–2006. Clin Infect Dis 2008; 46: 970–6.CrossRefGoogle Scholar
Hlady, WG, Klontz, KC. The epidemiology of Vibrio infections in Florida, 1981–1993. J Infect Dis 1996; 173: 1176–83.CrossRefGoogle ScholarPubMed
Hlady, WG, Mullen, RC, Hopkin, RS. Vibrio vulnificus from raw oysters. Leading cause of reported deaths from foodborne illness in Florida. J Fla Med Assoc 1993; 80: 536–8.Google ScholarPubMed
Shih, YT, Peng, CT, Tsai, CH, Tsai, FJ. [Beta-thalassemia major complicated with Vibrio vulnificus septicemia: report of one case.]Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi 1994; 35: 84–9.Google Scholar
Chang, JJ, Sheen, IS, Peng, SM, Chen, PC, Wu, CS, Leu, HS. Vibrio vulnificus infection–report of 8 cases and review of cases in Taiwan. Changgeng Yi Xue Za Zhi 1994; 17: 339–46.Google ScholarPubMed
Kuo, CH, Dai, ZK, Wu, JR, Hsieh, TJ, Hung, CH, Hsu, JH. Septic arthritis as the initial manifestation of fatal Vibrio vulnificus septicemia in a patient with thalassemia and iron overload. Pediatr Blood Cancer 2009; 53: 1156–8.CrossRefGoogle Scholar
Wang, SC, Lin, KH, Chern, JP, et al. Severe bacterial infection in transfusion-dependent patients with thalassemia major. Clin Infect Dis 2003; 37: 984–8.CrossRefGoogle ScholarPubMed
Katz, BZ. Vibrio vulnificus meningitis in a boy with thalassemia after eating raw oysters. Pediatrics 1988; 82: 784–6.Google Scholar
Ashrafian, H. Hepcidin: the missing link between hemochromatosis and infections. Infect Immun 2003; 71: 669300.CrossRefGoogle ScholarPubMed
Gholami, P, Lew, SQ, Klontz, KC. Raw shellfish consumption among renal disease patients. A risk factor for severe Vibrio vulnificus infection. Am J Prev Med 1998; 15: 243.CrossRefGoogle ScholarPubMed
Stabellini, N, Camerani, A, Lambertini, D, et al. Fatal sepsis from Vibrio vulnificus in a hemodialyzed patient. Nephron 1998; 78: 221–4.CrossRefGoogle Scholar
Wang, SM, Liu, CC, Chiou, YY, Yang, HB, Chen, CT. Vibrio vulnificus infection complicated by acute respiratory distress syndrome in a child with nephrotic syndrome. Pediatr Pulmonol 2000; 29: 400–3.3.0.CO;2-J>CrossRefGoogle Scholar
Ruiz, CC, Agraharkar, M. Unusual marine pathogens causing cellulitis and bacteremia in hemodialysis patients: report of two cases and review of the literature. Hemodial Int 2003; 7: 356–9.CrossRefGoogle ScholarPubMed
Wright, AC, Simpson, LM, Oliver, JD. Role of iron in the pathogenesis of Vibrio vulnificus infections. Infect Immun 1981; 34: 503.Google ScholarPubMed
Hor, LI, Chang, TT, Wang, ST. Survival of Vibrio vulnificus in whole blood from patients with chronic liver diseases: association with phagocytosis by neutrophils and serum ferritin levels. J Infect Dis 1999; 179: 275–8.CrossRefGoogle ScholarPubMed
Hor, LI, Chang, YK, Chang, CC, Lei, HY, Ou, JT. Mechanism of high susceptibility of iron-overloaded mouse to Vibrio vulnificus infection. Microbiol Immunol 2000; 44: 871–8.CrossRefGoogle ScholarPubMed
Neupane, GP, Kim, DM. Comparison of the effects of deferasirox, deferiprone, and deferoxamine on the growth and virulence of Vibrio vulnificus. Transfusion 2009; 49: 1762–9.
Barton, JC, Bertoli, LF, Rothenberg, BE. Peripheral blood erythrocyte parameters in hemochromatosis: evidence for increased erythrocyte hemoglobin content. J Lab Clin Med 2000; 135: 96–104.CrossRefGoogle ScholarPubMed
Adams, PC, Reboussin, DM, Barton, JC, et al. Hemochromatosis and iron-overload screening in a racially diverse population. N Engl J Med 2005; 352: 17698.CrossRefGoogle Scholar
Beckman, EN, Leonard, GL, Castillo, , Genre, CF, Pankey, GA. Histopathology of marine vibrio wound infections. Am J Clin Pathol 1981; 76: 7652.CrossRefGoogle ScholarPubMed
Shinoda, S. [Pathogenic factors of vibrios with special emphasis on Vibrio vulnificus.]Yakugaku Zasshi 2005; 125: 531–47.CrossRefGoogle Scholar
Litwin, CM, Byrne, BL. Cloning and characterization of an outer membrane protein of Vibrio vulnificus required for heme utilization: regulation of expression and determination of the gene sequence. Infect Immun 1998; 66: 3134–41.Google ScholarPubMed
Kim, CM, Park, RY, Park, JH, et al. Vibrio vulnificus vulnibactin, but not metalloprotease VvpE, is essentially required for iron-uptake from human holotransferrin. Biol Pharm Bull 2006; 29: 911–18.CrossRefGoogle Scholar
Colodner, R, Chazan, B, Kopelowitz, J, Keness, Y, Raz, R. Unusual portal of entry of Vibrio vulnificus: evidence of its prolonged survival on the skin. Clin Infect Dis 2002; 34: 714–15.CrossRefGoogle ScholarPubMed
Witte, DL, Crosby, WH, Edwards, CQ, Fairbanks, VF, Mitros, FA. Practice guideline development task force of the College of American Pathologists. Hereditary hemochromatosis. Clin Chim Acta 1996; 245: 139–200.CrossRefGoogle ScholarPubMed
Barton, JC, McDonnell, SM, Adams, PC, et al. Management of hemochromatosis. Hemochromatosis Management Working Group. Ann Intern Med 1998; 129: 932–9.CrossRefGoogle ScholarPubMed
Gilbert, DN, Moellering, RC, Eliopoulos, GM, Sande, MA, eds. The Sanford Guide to Antimicrobial Therapy, 38th edn. Sperryville, Antimicrobial Therapy Inc. 2008.
Stoddard, JJ, Wechsler, DS, Nataro, JP, Casella, JF. Yersinia enterocolitica infection in a patient with sickle cell disease after exposure to chitterlings. Am J Pediatr Hematol Oncol 1994; 16: 153.Google Scholar
Lafleur, L, Hammerberg, O, Delage, G, Pai, CH. Yersinia enterocolitica infection in children: 4 years experience in the Montreal urban community. Contrib Microbiol Immunol 1979; 5: 298–303.Google ScholarPubMed
Adamkiewicz, TV, Berkovitch, M, Krishnan, C, Polsinelli, C, Kermack, D, Olivieri, NF. Infection due to Yersinia enterocolitica in a series of patients with beta-thalassemia: incidence and predisposing factors. Clin Infect Dis 1998; 27: 1362–6.CrossRefGoogle Scholar
Ewald, JH, Heesemann, J, Rudiger, H, Autenrieth, IB. Interaction of polymorphonuclear leukocytes with Yersinia enterocolitica: role of the Yersinia virulence plasmid and modulation by the iron-chelator desferrioxamine B. J Infect Dis 1994; 170: 1400.CrossRefGoogle ScholarPubMed
Lesic, B, Foulon, J, Carniel, E. Comparison of the effects of deferiprone versus deferoxamine on growth and virulence of Yersinia enterocolitica. Antimicrob Agents Chemother 2002; 46: 1741.CrossRefGoogle ScholarPubMed
Capron, JP, Capron-Chivrac, D, Tossou, H, Delamarre, J, Eb, F. Spontaneous Yersinia enterocolitica peritonitis in idiopathic hemochromatosis. Gastroenterology 1984; 87: 1372.Google ScholarPubMed
Green, NS. Yersinia infections in patients with homozygous beta-thalassemia associated with iron overload and its treatment. Pediatr Hematol Oncol 1992; 9: 2474.CrossRefGoogle ScholarPubMed
Cherchi, GB, Pacifico, L, Cossellu, S, et al. Prospective study of Yersinia enterocolitica infection in thalassemic patients. Pediatr Infect Dis J 1995; 14: 579–84.CrossRefGoogle ScholarPubMed
Hansen, MG, Pearl, G, Levy, M. Intussusception due to Yersinia enterocolitica enterocolitis in a patient with beta-thalassemia. Arch Pathol Lab Med 2001; 125: 1486–8.Google Scholar
Pallister, C, Rotstein, OD. Yersinia enterocolitica as a cause of intra-abdominal abscess: the role of iron. Can J Surg 2001; 44: 135–6.Google Scholar
Greco, L, Marino, F, Gentile, A, Catalano, G, Angilletta, D. Yersinia enterocolitica ileocolitis in beta-thalassemic patients. Colorectal Dis 2006; 8: 525.CrossRefGoogle ScholarPubMed
Bullen, JJ, Spalding, PB, Ward, CG, Gutteridge, JM. Hemochromatosis, iron and septicemia caused by Vibrio vulnificus. Arch Intern Med 1991; 151: 1606–9.CrossRefGoogle ScholarPubMed
Hewstone, AS, Davidson, GP. Yersinia enterocolitica septicaemia with arthritis in a thalassaemic child. Med J Aust 1972; 1: 1035–8.Google Scholar
Thirumoorthi, MC, Dajani, AS. Yersinia enterocolitica osteomyelitis in a child. Am J Dis Child 1978; 132: 578–80.Google Scholar
Virgiliis, S, Dessi, S, Melis, R, Cao, A. Fatal Yersinia enterocolitica meningitis in thalassemia major. Boll Ist Sieroter Milan 1984; 63: 171–2.Google ScholarPubMed
Gordts, B, Rummens, E, deMeirleir, L, Butzler, JP. Yersinia pseudotuberculosis septicaemia in thalassaemia major. Lancet 1984; 1: 41–2.CrossRefGoogle ScholarPubMed
Pierron, H, Gillet, R, Perrimond, H, Broudeur, JC, Soudry, G. [Yersinia infection and hemoglobin disorder. Apropos of 4 cases.]Pediatrie 1990; 45: 379–82.Google Scholar
Blei, F, Puder, DR. Yersinia enterocolitica bacteremia in a chronically transfused patient with sickle cell anemia. Case report and review of the literature. Am J Pediatr Hematol Oncol 1993; 15: 430–4.Google Scholar
Kruger, N, Kraus, C, Tillmann, W, Schroter, W. [Frequent occurrence of Yersinia infection in hemosiderosis.]Monatsschr Kinderheilkd 1985; 133: 876–8.Google Scholar
Stuart, SJ, Greenwood, KT, Luke, RK. Iron-suppressible production of hydroxamate by Escherichia coli isolates. Infect Immun 1982; 36: 870.Google ScholarPubMed
Neilands, JB. Parallels in the mode of regulation of iron assimilation in all living species. In: Ponka, P, Schulman, HM, Woodworth, RC, eds. Iron Transport and Storage. Boca Raton, CRC Press, Inc. 1990; 424.Google Scholar
Ouyang, Z, Isaacson, R. Identification and characterization of a novel ABC iron transport system, fit, in Escherichia coli. Infect Immun 2006; 74: 69496.CrossRefGoogle ScholarPubMed
Bullen, JJ. Iron-binding proteins and other factors in milk responsible for resistance to Escherichia coli. Ciba Found Symp 1976; 149–69.Google ScholarPubMed
Rogers, HJ. Ferric iron and the antibacterial effects of horse 7S antibodies to Escherichia coli O111. Immunology 1976; 30: 425–33.Google ScholarPubMed
Baltimore, RS, Shedd, DG, Pearson, HA. Effect of iron saturation on the bacteriostasis of human serum: in vivo does not correlate with in vitro saturation. J Pediatr 1982; 101: 519–23.CrossRefGoogle Scholar
Rivier, D, Page, N, Isliker, H. Synergism between iron chelators and complement for bactericidal activity. Ann Immunol (Paris) 1983; 134C: 25–30.Google ScholarPubMed
Chart, H, Buck, M, Stevenson, P, Griffiths, E. Iron regulated outer membrane proteins of Escherichia coli: variations in expression due to the chelator used to restrict the availability of iron. J Gen Microbiol 1986; 132: 1373–8.Google Scholar
Rainard, P. Bacteriostasis of Escherichia coli by bovine lactoferrin, transferrin, and immunoglobulins (IgG1, IgG2, IgM) acting alone or in combination. Vet Microbiol 1986; 11: 103–15.CrossRefGoogle ScholarPubMed
Brock, JH, Liceaga, J, Kontoghiorghes, GJ. The effect of synthetic iron chelators on bacterial growth in human serum. FEMS Microbiol Immunol 1988; 1: 55–60.CrossRefGoogle ScholarPubMed
Peng, CT, Tsai, CH, Wang, JH, Chiu, CF, Chow, KC. Bacterial infection in patients with transfusion-dependent beta-thalassemia in central Taiwan. Acta Paediatr Taiwan 2000; 41: 318–21.Google ScholarPubMed
Wanachiwanawin, W. Infections in E-beta-thalassemia. J Pediatr Hematol Oncol 2000; 22: 581.CrossRefGoogle ScholarPubMed
Alebouyeh, M, Moussavi, F. Occurrence of overwhelming Gram-negative infections in splenectomised patients with thalassaemia major. Eur J Pediatr 2003; 162: 637–8.CrossRefGoogle ScholarPubMed
Becroft, DM, Dix, MR, Farmer, K. Intramuscular iron-dextran and susceptibility of neonates to bacterial infections. In vitro studies. Arch Dis Child 1977; 52: 778–81.CrossRefGoogle ScholarPubMed
Zala, G. [Acute abdomen with irreversible shock, a rare but typical complication of hemochromatosis.]Schweiz Med Wochenschr 1985; 115: 1461.Google Scholar
Jain, AP, Chandra, LS, Gupta, S, Gupta, OP, Jajoo, UN, Kalantri, SP. Spontaneous bacterial peritonitis in liver cirrhosis with ascites. J Assoc Physicians India 1999; 47: 619–21.Google ScholarPubMed
Dinis-Ribeiro, M, Cortez-Pinto, H, Marinho, R, et al. Spontaneous bacterial peritonitis in patients with hepatic cirrhosis: evaluation of a treatment protocol at specialized units. Rev Esp Enferm Dig 2002; 94: 473–81.Google ScholarPubMed
Thanopoulou, AC, Koskinas, JS, Hadziyannis, SJ. Spontaneous bacterial peritonitis (SBP): clinical, laboratory, and prognostic features. A single-center experience. Eur J Intern Med 2002; 13: 194–8.CrossRefGoogle ScholarPubMed
Caruntu, FA, Benea, L. Spontaneous bacterial peritonitis: pathogenesis, diagnosis, treatment. J Gastrointestin Liver Dis 2006; 15: 51–6.Google Scholar
Erpecum, KJ. Ascites and spontaneous bacterial peritonitis in patients with liver cirrhosis. Scand J Gastroenterol Suppl 2006; 79–84.
Ribeiro, TC, Chebli, JM, Kondo, M, Gaburri, PD, Chebli, , Feldner, AC. Spontaneous bacterial peritonitis: How to deal with this life-threatening cirrhosis complication? Ther Clin Risk Manag 2008; 4: 919–25.CrossRefGoogle ScholarPubMed
Bert, F, Panhard, X, Johnson, J, et al. Genetic background of Escherichia coli isolates from patients with spontaneous bacterial peritonitis: relationship with host factors and prognosis. Clin Microbiol Infect 2008; 14: 1034–40.CrossRefGoogle ScholarPubMed
Cereto, F, Herranz, X, Moreno, E, et al. Role of host and bacterial virulence factors in Escherichia coli spontaneous bacterial peritonitis. Eur J Gastroenterol Hepatol 2008; 20: 924–9.CrossRefGoogle ScholarPubMed
Desforges, G. Abdominal pain in hemochromatosis. N Engl J Med 1949; 241: 485.CrossRefGoogle ScholarPubMed
Jones, NL. Irreversible shock in haemochromatosis. Lancet 1962; 1: 5692.CrossRefGoogle ScholarPubMed
Garvie, WH, Caridis, DT. Idiopathic hemochromatosis presenting as “acute abdomen”: a report of two cases. Can J Surg 1970; 13: 262–6.Google ScholarPubMed
Cuenca-Moron, B, Solis-Herruzo, JA, Moreno, D, Guijarro, C, Gentil, AA, Castellano, G. Spontaneous bacterial peritonitis due to Yersinia enterocolitica in secondary alcoholic hemochromatosis. J Clin Gastroenterol 1989; 11: 675–8.CrossRefGoogle ScholarPubMed
Rex, JH, Ginsberg, AM, Fries, LF, Pass, HI, Kwon-Chung KJ. Cunninghamella bertholletiae infection associated with deferoxamine therapy. Rev Infect Dis 1988; 10: 1187–94.CrossRefGoogle ScholarPubMed
Gaziev, D, Baronciani, D, Galimberti, M, et al. Mucormycosis after bone marrow transplantation: report of four cases in thalassemia and review of the literature. Bone Marrow Transplant 1996; 17: 409–14.Google ScholarPubMed
Beutler, E, Gelbart, T. Helicobacter pylori infection and HFE hemochromatosis. Blood Cells Mol Dis 2006; 37: 188–91.CrossRefGoogle ScholarPubMed
Montalembert, M, Girot, R. Infections in thalassemic patients (hepatitis and bone marrow transplantation-related infections excluded). Prog Clin Biol Res 1989; 309: 231–8.Google Scholar
Wanachiwanawin, W. Infections in E-beta-thalassemia. J Pediatr Hematol Oncol 2000; 22: 581.CrossRefGoogle ScholarPubMed
Rahav, G, Volach, V, Shapiro, M, Rund, D, Rachmilewitz, EA, Goldfarb, A. Severe infections in thalassaemic patients: prevalence and predisposing factors. Br J Haematol 2006; 133: 6674.CrossRefGoogle ScholarPubMed
Virgiliis, S, Fiorelli, G, Fargion, S, et al. Chronic liver disease in transfusion-dependent thalassaemia: hepatitis B virus marker studies. J Clin Pathol 1980; 33: 9493.CrossRefGoogle ScholarPubMed
Fargion, S, Piperno, A, Cappellini, MD, et al. Hepatitis C virus and porphyria cutanea tarda: evidence of a strong association. Hepatology 1992; 16: 1322–6.CrossRefGoogle ScholarPubMed
Sampietro, M, Corbetta, N, Cerino, M, et al. Prevalence and clinical significance of hepatitis G virus infection in adult beta-thalassaemia major patients. Br J Haematol 1997; 97: 904.CrossRefGoogle ScholarPubMed
Edwards, CQ, Griffen, LM, Kushner, JP. Coincidental hemochromatosis and viral hepatitis. Am J Med Sci 1991; 301: 50–4.CrossRefGoogle ScholarPubMed
Piperno, A, Fargion, S, D'Alba, R, et al. Liver damage in Italian patients with hereditary hemochromatosis is highly influenced by hepatitis B and C virus infection. J Hepatol 1992; 16: 364–8.CrossRefGoogle ScholarPubMed
Strachan, AS. Haemosiderosis and haemochromatosis in South African natives with a comment on the etiology of haemochromatosis. MD Thesis. University of Glasgow, 1929.Google Scholar
Kasvosve, I, Gangaidzo, IT, Gomo, ZA, Gordeuk, VR. African iron overload. Acta Clin Belg 2000; 55: 88–93.CrossRefGoogle ScholarPubMed
Boelaert, JR, Vandecasteele, SJ, Appelberg, R, Gordeuk, VR. The effect of the host's iron status on tuberculosis. J Infect Dis 2007; 195: 17453.CrossRefGoogle ScholarPubMed
Gordeuk, VR, Delanghe, JR, Langlois, MR, Boelaert, JR. Iron status and the outcome of HIV infection: an overview. J Clin Virol 2001; 20: 111–15.CrossRefGoogle ScholarPubMed
Barton, JC, Bertoli, LF. Histochemistry of iron and iron proteins. In: Barton, JC, Edwards, CQ, eds. Hemochromatosis: Genetics, Pathophysiology, Diagnosis and Treatment. Cambridge, Cambridge University Press. 2000; 200–218.CrossRefGoogle Scholar
Vet, BJ, ten Hoopen, CH. Lactoferrin in human neutrophilic polymorphonuclear leukocytes in relation to iron metabolism. Acta Med Scand 1978; 203: 197–203.CrossRefGoogle ScholarPubMed
Chung, S, Hayward, C, Brock, DJ, Heyningen, V. A monoclonal antibody-based immunoassay for human lactoferrin. J Immunol Methods 1985; 84: 135–41.CrossRefGoogle ScholarPubMed
Moguilevsky, N, Masson, PL, Courtoy, PJ. Lactoferrin uptake and iron processing into macrophages: a study in familial haemochromatosis. Br J Haematol 1987; 66: 129–36.CrossRefGoogle ScholarPubMed
Butler, TW, Heck, LW, Huster, WJ, Grossi, CE, Barton, JC. Assessment of total immunoreactive lactoferrin in hematopoietic cells using flow cytometry. J Immunol Methods 1988; 108: 1590.CrossRefGoogle ScholarPubMed
Barton, JC, Huster, WJ, Parmley, RT. Iron-binding reactivity in mature neutrophils: relative cell content quantification by cytochemical scoring. J Histochem Cytochem 1988; 36: 6498.CrossRefGoogle ScholarPubMed
Asbeck, BS, Marx, JJ, Struyvenberg, A, Verhoef, J. Functional defects in phagocytic cells from patients with iron overload. J Infect 1984; 8: 232–40.CrossRefGoogle ScholarPubMed
Butler, TW, Heck, LW, Berkow, R, Barton, JC. Radioimmunometric quantification of surface lactoferrin in blood mononuclear cells. Am J Med Sci 1994; 307: 102.CrossRefGoogle ScholarPubMed
Moura, E, Verheul, AF, Marx, JJ. A functional defect in hereditary haemochromatosis monocytes and monocyte-derived macrophages. Eur J Clin Invest 1998; 28: 1643.CrossRefGoogle ScholarPubMed
Moura, E, Verheul, AF, Marx, JJ. Evaluation of the role of Fc gamma and complement receptors in the decreased phagocytosis of hereditary haemochromatosis patients. Scand J Immunol 1997; 46: 399–405.CrossRefGoogle ScholarPubMed
Amadori, A, Zamarchi, R, Silvestro, G, et al. Genetic control of the CD4/CD8 T-cell ratio in humans. Nat Med 1995; 1: 1279–83.CrossRefGoogle ScholarPubMed
Hall, MA, Ahmadi, KR, Norman, P, et al. Genetic influence on peripheral blood T lymphocyte levels. Genes Immun 2000; 1: 423.CrossRefGoogle ScholarPubMed
Barton, JC, Wiener, HW, Acton, RT, Go, RC. Total blood lymphocyte counts in hemochromatosis probands with HFE C282Y homozygosity: relationship to severity of iron overload and HLA-A and -B alleles and haplotypes. BMC Blood Disord 2005; 5: 5.Google Scholar
Cruz, E, Vieira, J, Almeida, S, et al. A study of 82 extended HLA haplotypes in HFE-C282Y homozygous hemochromatosis subjects: relationship to the genetic control of CD8+ T-lymphocyte numbers and severity of iron overload. BMC Med Genet 2006; 7: 16.CrossRefGoogle ScholarPubMed
Arosa, FA, Oliveira, L, Porto, G, et al. Anomalies of the CD8+ T cell pool in haemochromatosis: HLA-A3-linked expansions of CD8+. Clin Exp Immunol 1997; 107: 5484.CrossRefGoogle ScholarPubMed
Reimao, R, Porto, G, Sousa, M. Stability of CD4/CD8 ratios in man: new correlation between CD4/CD8 profiles and iron overload in idiopathic haemochromatosis patients. C R Acad Sci III 1991; 313: 481.Google ScholarPubMed
Porto, G, Reimao, R, Goncalves, C, Vicente, C, Justica, B, Sousa, M. Haemochromatosis as a window into the study of the immunological system: a novel correlation between CD8+ lymphocytes and iron overload. Eur J Haematol 1994; 52: 283–90.CrossRefGoogle Scholar
Nemeth, E, Valore, EV, Territo, M, Schiller, G, Lichtenstein, A, Ganz, T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003; 101: 2461–3.CrossRefGoogle ScholarPubMed
Feder, JN, Gnirke, A, Thomas, W, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 1996; 13: 399–408.CrossRefGoogle ScholarPubMed
Parkkila, S, Parkkila, AK, Waheed, A, et al. Cell surface expression of HFE protein in epithelial cells, macrophages, and monocytes. Haematologica 2000; 85: 340.Google ScholarPubMed
Chitambar, CR, Wereley, JP. Expression of the hemochromatosis (HFE) gene modulates the cellular uptake of 67Ga. J Nucl Med 2003; 44: 943–6.Google ScholarPubMed
Feeney, GP, Carter, K, Masters, GS, Jackson, HA, Cavil, I, Worwood, M. Changes in erythropoiesis in hereditary hemochromatosis are not mediated by HFE expression in nucleated red cells. Haematologica 2005; 90: 180.Google Scholar
Miranda, CJ, Makui, H, Andrews, NC, Santos, MM. Contributions of beta2-microglobulin-dependent molecules and lymphocytes to iron regulation: insights from HfeRag1(-/-) and beta2mRag1(-/-) double knockout mice. Blood 2004; 103: 2847–9.CrossRefGoogle Scholar
Pratiwi, R, Fletcher, LM, Pyper, WR, et al. Linkage disequilibrium analysis in Australian haemochromatosis patients indicates bipartite association with clinical expression. J Hepatol 1999; 31: 39–46.CrossRefGoogle ScholarPubMed
Acton, RT, Snively, BM, Barton, JC, et al. A genome-wide linkage scan for iron phenotype quantitative trait loci: the HEIRS Family Study. Clin Genet 2007; 71: 518–29.CrossRefGoogle ScholarPubMed
Barton, JC, Bertoli, LF, Acton, RT. Common variable immunodeficiency and IgG subclass deficiency in central Alabama hemochromatosis probands homozygous for HFE C282Y. Blood Cells Mol Dis 2003; 31: 102–11.CrossRefGoogle ScholarPubMed
Joske, RA, Traub, M. Haemochromatosis, active chronic hepatitis, and familial IgA deficiency. Digestion 1975; 12: 32–8.CrossRefGoogle ScholarPubMed
Jolivet-Gougeon, A, Ingels, A, Danic, B, et al. No increased seroprevalence of anti-Yersinia antibodies in patients with type 1 (C282Y/C282Y) hemochromatosis. Scand J Gastroenterol 2007; 42: 1388–9.CrossRefGoogle ScholarPubMed
Barton, JC, Acton, RT. HLA-A and -B alleles and haplotypes in hemochromatosis probands with HFE C282Y homozygosity in central Alabama. BMC Med Genet 2002; 3: 9.CrossRefGoogle Scholar
Barton, JC, Bertoli, LF, Acton, RT. HLA-A and -B alleles and haplotypes in 240 index patients with common variable immunodeficiency and selective IgG subclass deficiency in central Alabama. BMC Med Genet 2003; 4: 3.CrossRefGoogle Scholar
Spickett, GP, Farrant, J, North, ME, Zhang, JG, Morgan, L, Webster, AD. Common variable immunodeficiency: how many diseases?Immunology Today 1997; 18: 325–8.CrossRefGoogle ScholarPubMed
Alper, CA, Marcus-Bagley, D, Awdeh, Z, et al. Prospective analysis suggests susceptibility genes for deficiencies of IgA and several other immunoglobulins on the [HLA-B8, SC01, DR3] conserved extended haplotype. Tissue Antigens 2000; 56: 207–16.CrossRefGoogle ScholarPubMed
Vorechovsky, I, Cullen, M, Carrington, M, Hammarstrom, L, Webster, AD. Fine mapping of is in IgA deficiency and common variable immunodeficiency: identification and characterization of haplotypes shared by affected members of 101 multiple-case families. J Immunol 2000; 164: 4408–16.CrossRefGoogle ScholarPubMed
Kralovicova, J, Hammarstrom, L, Plebani, A, Webster, AD, Vorechovsky, I. Fine-scale mapping at IGAD1 and genome-wide genetic linkage analysis implicate HLA-DQ/DR as a major susceptibility locus in selective IgA deficiency and common variable immunodeficiency. J Immunol 2003; 170: 27655.CrossRefGoogle ScholarPubMed
Volanakis, JE, Zhu, ZB, Schaffer, FM, et al. Major histocompatibility complex class III genes and susceptibility to immunoglobulin A deficiency and common variable immunodeficiency. J Clin Invest 1992; 89: 1914–22.CrossRefGoogle ScholarPubMed
Concha, EG, Fernandez-Arquero, M, Gual, L, et al. MHC susceptibility genes to IgA deficiency are located in different regions on different HLA haplotypes. J Immunol 2002; 169: 4637–43.CrossRefGoogle ScholarPubMed
Castigli, E, Wilson, SA, Garibyan, L, et al. TACI is mutant in common variable immunodeficiency and IgA deficiency. Nat Genet 2005; 37: 829–34.CrossRefGoogle ScholarPubMed
Salzer, U, Chapel, HM, Webster, AD, et al. Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Nat Genet 2005; 37: 820–8.CrossRefGoogle ScholarPubMed
Mullighan, CG, Marshall, SE, Welsh, KI. Mannose-binding lectin polymorphisms are associated with early age of disease onset and autoimmunity in common variable immunodeficiency. Scand J Immunol 2000; 51: 111–22.CrossRefGoogle ScholarPubMed

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