Burton, S., Brown, G., Daniels, I. R., et al. MRI directed multidisciplinary team preoperative treatment strategy: the way to eliminate positive circumferential margins?Br J Cancer, 94:3 (2006), 351–7.CrossRefGoogle ScholarPubMed

Aigner, F., Zbar, A. P., Ludwikowski, B., et al. The rectogenital septum: morphology, function, and clinical relevance. Dis Colon Rectum, 47:2 (2004), 131–40.CrossRefGoogle ScholarPubMed

Heald, R. J., Moran, B. J., Brown, G., and Daniels, I.Optimal Total mesorectal excision for rectal cancer is in front of Denonvilliers Fascia. Br J Surg, 91:1 (2004), 121–3.CrossRefGoogle ScholarPubMed

Brown, G., Kirkham, A., Williams, G. T., et al. High-resolution MRI of the anatomy important in total mesorectal excision of the rectum. AJR Am J Roentgenol, 182:2 (2004), 431–9.CrossRefGoogle ScholarPubMed

Jass, J. R., Atkin, W. S., Cuzick, J., et al. The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases. Histopathology, 10:5 (1986), 437–59.CrossRefGoogle Scholar

Grinnell, R. S.The grading and prognosis of carcinoma of the colon and rectum. Ann Surg, 109 (1939), 500–33.CrossRefGoogle ScholarPubMed

Spratt, J. A. and Spjut, H. J.Prevalence and prognosis of carcinoma of the colon and rectum. Cancer, 20 (1967), 1976–85.3.0.CO;2-M>CrossRefGoogle Scholar

Andreola, S., Leo, E., Belli, F., Lavarino, C., Bufalino, R., Tomasic, G., Baldini, M. T., Valvo, F., Navarria, P., and Lombardi, F.Distal intramural spread in adenocarcinoma of the lower third of the rectum treated with total rectal resection and coloanal anastomosis. Dis Colon Rectum, 40:1 (1997), 25–9.CrossRefGoogle ScholarPubMed

Hughes, T. G., Jenevein, E. P., and Poulos, E.Intramural spread of colon carcinoma. A pathologic study. Am J Surg, 146:6 (1983), 697–9.CrossRefGoogle ScholarPubMed

Madsen, P. M. and Christiansen, J.Distal intramural spread of rectal carcinomas. Dis Colon Rectum, 29:4 (1986), 279–82.CrossRefGoogle ScholarPubMed

Schnall, M. D., Furth, E. E., Rosato, E. F., and Kressel, H. Y.Rectal tumor stage: correlation of endorectal MR imaging and pathologic findings. Radiology, 190:3 (1994), 709–14.CrossRefGoogle ScholarPubMed

Cohen, A. M., Wood, W. C., Gunderson, L. L., and Shinnar, M.Pathological studies in rectal cancer. Cancer, 45:12 (1980), 2965–8.3.0.CO;2-M>CrossRefGoogle ScholarPubMed

Bjerkeset, T., Morild, I., Mork, S., and Soreide, O.Tumor characteristics in colorectal cancer and their relationship to treatment and prognosis. Dis Colon Rectum, 30:12 (1987), 934–8.CrossRefGoogle ScholarPubMed

Michelassi, F., Vannucci, L., Montag, A., et al. Importance of tumor morphology for the long term prognosis of rectal adenocarcinoma. Am Surg, 54:6 (1988), 376–9.Google Scholar

Sasaki, O., Atkin, W. S., and Jass, J. R.Mucinous carcinoma of the rectum. Histopathology, 11:3 (1987), 259–72.CrossRefGoogle ScholarPubMed

Pihl, E., Nairn, R. C., Hughes, E. S., Cuthbertson, A. M., and Rollo, A. J.Mucinous colorectal carcinoma: immunopathology and prognosis. Pathology, 12:3 (1980), 439–47.CrossRefGoogle ScholarPubMed

Secco, G. B., Fardelli, R., Campora, E., et al. Primary mucinous adenocarcinomas and signet-ring cell carcinomas of colon and rectum. Oncology, 51:1 (1994), 30–4.CrossRefGoogle ScholarPubMed

Dukes, C. E.The classification of cancer of the rectum. J Path Bact, 35 (1932), 323.CrossRefGoogle Scholar

Harrison, J. C., Dean, P. J., el-Zeky, F., and Zwaag, Vander R.From Dukes through Jass: pathological prognostic indicators in rectal cancer [see comments]. Hum Pathol, 25:5 (1994), 498–505.CrossRefGoogle Scholar

Jass, J. R. and Love, S. B.Prognostic value of direct spread in Dukes' C cases of rectal cancer. Dis Colon Rectum, 32:6 (1989), 477–80.CrossRefGoogle ScholarPubMed

Murano, A., Sasaki, F., Kido, C., et al. Endoscopic MRI using 3D-spoiled GRASS (SPGR) sequence for local staging of rectal carcinoma. J Comput Assist Tomogr, 19:4 (1995), 586–91.CrossRefGoogle ScholarPubMed

Joosten, F. B., Jansen, J. B., Joosten, H. J., and Rosenbusch, G.Staging of rectal carcinoma using MR double surface coil, MR endorectal coil, and intrarectal ultrasound: correlation with histopathologic findings. J Comput Assist Tomogr, 19:5 (1995), 752–8.CrossRefGoogle ScholarPubMed

Pegios, W., Vogl, J., Mack, M. G., et al. MRI diagnosis and staging of rectal carcinoma. Abdom Imaging, 21:3 (1996), 211–18.CrossRefGoogle ScholarPubMed

Vogl, T. J., Pegios, W., Mack, M. G., et al. Radiological modalities in the staging of colorectal tumors: new perspectives for increasing accuracy. Recent Results Cancer Res, 142 (1996), 103–20.CrossRefGoogle ScholarPubMed

Okizuka, H., Sugimura, K., Yoshizako, T., Kaji, Y., and Wada, A.Rectal carcinoma: prospective comparison of conventional and gadopentetate dimeglumine enhanced fat-suppressed MR imaging. J Magn Reson Imaging, 6:3 (1996), 465–71.CrossRefGoogle ScholarPubMed

Willett, C. G., Badizadegan, K., Ancukiewicz, M., and Shellito, P. C.Prognostic factors in stage T3N0 rectal cancer: do all patients require postoperative pelvic irradiation and chemotherapy?Dis Colon Rectum, 42:2 (1999), 167–73.CrossRefGoogle ScholarPubMed

Cawthorn, S. J., Parums, D. V., Gibbs, N. M., et al. Extent of mesorectal spread and involvement of lateral resection margin as prognostic factors after surgery for rectal cancer [see comments]. Lancet, 335:8697 (1990), 1055–9.CrossRefGoogle Scholar

Merkel, S., Mansmann, U., Papadopoulos, T., et al. The prognostic inhomogeneity of colorectal carcinomas Stage III: a proposal for subdivision of Stage III. Cancer, 92:11 (2001), 2754–9.3.0.CO;2-4>CrossRefGoogle ScholarPubMed

Brown, G., Radcliffe, A. G., Newcombe, R. G., et al. Preoperative assessment of prognostic factors in rectal cancer using high-resolution magnetic resonance imaging. Br J Surg, 90:3 (2003), 355–64.CrossRefGoogle ScholarPubMed

Brown, G., Richards, C. J., Newcombe, R. G., et al. Rectal carcinoma: thin-section MR imaging for staging in 28 patients. Radiology, 211:1 (1999), 215–22.CrossRefGoogle ScholarPubMed

Shepherd, N. A., Baxter, K. J., and Love, S. B. The prognostic importance of peritoneal involvement in colonic cancer: a prospective evaluation. Gastroenterology, 112:4 (1997), 1096–102.CrossRefGoogle ScholarPubMed

Shepherd, N. A., Baxter, K. J., and Love, S. B. Influence of local peritoneal involvement on pelvic recurrence and prognosis in rectal cancer. J Clin Pathol, 48:9 (1995), 849–55.CrossRefGoogle ScholarPubMed

Dukes, C. E., and Bussey, H. J.The spread of cancer and its effect on prognosis. Cancer, 12 (1958), 309–20.CrossRefGoogle ScholarPubMed

Moran, M. R., James, E. C., Rothenberger, D. A., and Goldberg, S. M.Prognostic value of positive lymph nodes in rectal cancer. Dis Colon Rectum, 35:6 (1992), 579–81.CrossRefGoogle ScholarPubMed

Wolmark, N., Fisher, E. R., Wieand, H. S., and Fisher, B.The relationship of depth of penetration and tumor size to the number of positive nodes in Dukes C colorectal cancer. Cancer, 53:12 (1984), 2707–12.3.0.CO;2-R>CrossRefGoogle ScholarPubMed

Andreola, S., Leo, E., Belli, F., et al. Manual dissection of adenocarcinoma of the lower third of the rectum specimens for detection of lymph node metastases smaller than 5 mm. Cancer, 77:4 (1996), 607–12.3.0.CO;2-D>CrossRefGoogle ScholarPubMed

Chau, I., Allen, M., Cunningham, D., et al. Neoadjuvant systemic fluorouracil and mitomycin C prior to synchronous chemoradiation is an effective strategy in locally advanced rectal cancer. Br J Cancer, 88:7 (2003), 1017–24.CrossRefGoogle ScholarPubMed

Chau, I., Brown, G., Cunningham, D., et al. Neoadjuvant capecitabine and oxaliplatin followed by synchronous chemoradiation and total mesorectal excision in magnetic resonance imaging-defined poor-risk rectal cancer. J Clin Oncol, 24:4 (2006), 668–74.CrossRefGoogle ScholarPubMed

Adam, I. J., Mohamdee, M. O., Martin, I. G., et al. Role of circumferential margin involvement in the local recurrence of rectal cancer. Lancet, 344:8924 (1994), 707–11.CrossRefGoogle ScholarPubMed

Morita, T., Murata, A., Koyama, M., Totsuka, E., and Sasaki, M.Current status of autonomic nerve-preserving surgery for mid and lower rectal cancers: Japanese experience with lateral node dissection. Dis Colon Rectum 46:suppl. 10 (2003), S78–87, discussion S87–8.Google ScholarPubMed

Suzuki, K., Muto, T., and Sawada, T.Prevention of local recurrence by extended lymphadenectomy for rectal cancer. Surg Today, 25:9 (1995), 795–801.CrossRefGoogle ScholarPubMed

Billingham, R. P.Extended lymphadenectomy for rectal cancer: cure vs quality of life. Int Surg, 79:1 (1994), 11–22.Google ScholarPubMed

Moreira, L. F., Hizuta, A., Iwagaki, H., Tanaka, N., and Orita, K.Lateral lymph node dissection for rectal carcinoma below the peritoneal reflection. Br J Surg, 81:2 (1994), 293–6.CrossRefGoogle ScholarPubMed

Koch, M., Kienle, P., Antolovic, D., Buchler, M. W., and Weitz, J.Is the lateral lymph node compartment relevant?Recent Results Cancer Res, 165 (2005), 40–5.CrossRefGoogle ScholarPubMed

Kikuchi, R., Takano, M., Takagi, K., et al. Management of early invasive colorectal cancer. Risk of recurrence and clinical guidelines [see comments]. Dis Colon Rectum, 38:12 (1995), 1286–95.CrossRefGoogle ScholarPubMed

Gall, F. P.Cancer of the rectum – local excision. Int J Colorectal Dis, 6:2 (1991), 84–5.CrossRefGoogle ScholarPubMed

Dworak, O.Morphology of lymph nodes in the resected rectum of patients with rectal carcinoma. Pathol, Res Pract 187:8 (1991), 1020–4.CrossRefGoogle ScholarPubMed

Hulsmans, F. H., Bosma, A., Mulder, P. J., Reeders, J. W., and Tytgat, G. N.Perirectal lymph nodes in rectal cancer: in vitro correlation of sonographic parameters and histopathologic findings. Radiology, 184:2 (1992), 553–60.CrossRefGoogle ScholarPubMed

Hildebrandt, U., Klein, T., Feifel, G., et al. Endosonography of pararectal lymph nodes. In vitro and in vivo evaluation. Dis Colon Rectum, 33:10 (1990), 863–8.CrossRefGoogle ScholarPubMed

Katsura, Y., Yamada, K., Ishizawa, T., Yoshinaka, H., and Shimazu, H.Endorectal ultrasonography for the assessment of wall invasion and lymph node metastasis in rectal cancer. Dis Colon Rectum, 35:4 (1992), 362–8.CrossRefGoogle ScholarPubMed

Brown, G., Richards, C. J., Bourne, M. W.,et al. Morphologic predictors of lymph node status in rectal cancer with use of high-spatial-resolution MR imaging with histopathologic comparison. Radiology, 227:2 (2003), 371–7.CrossRefGoogle ScholarPubMed

Detry, R. J., Kartheuser, A. H., Lagneaux, G., and Rahier, J.Preoperative lymph node staging in rectal cancer: a difficult challenge. Int J Colorectal Dis, 11:5 (1996), 217–21.CrossRefGoogle ScholarPubMed

Spinelli, P., Schiavo, M., Meroni, E., et al. Results of EUS in detecting perirectal lymph node metastases of rectal cancer: the pathologist makes the difference. Gastrointest Endosc, 49:6 (1999), 754–8.CrossRefGoogle ScholarPubMed

Talbot, I. C., Ritchie, S., Leighton, M. H., et al. The clinical significance of invasion of veins by rectal cancer. Br J Surg, 67:6 (1980), 439–42.CrossRefGoogle ScholarPubMed

Horn, A., Dahl, O., and Morild, I.The role of venous and neural invasion on survival in rectal adenocarcinoma. Dis Colon Rectum, 33:7 (1990), 598–601.CrossRefGoogle ScholarPubMed

Horn, A., Dahl, O., and Morild, I.Venous and neural invasion as predictors of recurrence in rectal adenocarcinoma. Dis Colon Rectum, 34:9 (1991), 798–804.CrossRefGoogle ScholarPubMed

Heald, R. J. and Ryall, R. D.Recurrence and survival after total mesorectal excision for rectal cancer. Lancet, 1:8496 (1986), 1479–82.CrossRefGoogle ScholarPubMed

Bokey, E. L., Chapuis, P. H., Dent, O. F., et al. Factors affecting survival after excision of the rectum for cancer: a multivariate analysis. Dis Colon Rectum, 40:1 (1997), 3–10.CrossRefGoogle ScholarPubMed

Hall, N. R., Finan, P. J., al-Jaberi, T., et al. Circumferential margin involvement after mesorectal excision of rectal cancer with curative intent. Predictor of survival but not local recurrence?Dis Colon Rectum, 41:8 (1998), 979–83.CrossRefGoogle Scholar

Quirke, P. and Dixon, M. F.The prediction of local recurrence in rectal adenocarcinoma by histopathological examination. Int J Colorectal Dis, 3:2 (1988), 127–31.CrossRefGoogle ScholarPubMed

Quirke, P., Durdey, P., Dixon, M. F., and Williams, N. S.Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumour spread and surgical excision. Lancet, 2:8514 (1986), 996–9.CrossRefGoogle ScholarPubMed

Sebag-Montefiore, D., Glynne-Jones, R., Mortensen, N., et al. Pooled analysis of outcome measures including the histopatological R0 resection rate after pre-operative chemoradiation for locally advanced rectal cancer. In Finan, P. J., ed., Tripartite 2005 Colorectal Meeting (Dublin, Ireland: Blackwell Publishing, 2005), p. 7.Google Scholar

Burton, S., Brown, G., Daniels, I., et al. MRI identified prognostic features of tumors in distal sigmoid, rectosigmoid, and upper rectum: Treatment with radiotherapy and chemotherapy. Int J Radiat Oncol Biol Phys, 65:2 (2006), 445–51.CrossRefGoogle ScholarPubMed

Bateman, A. C., Carr, N. J., and Warren, B. F.The retroperitoneal surface in distal caecal and proximal ascending colon carcinoma: the Cinderella surgical margin?J Clin Pathol, 58:4 (2005), 426–8.CrossRefGoogle ScholarPubMed