Gastrointestinal tract

doi:10.1017/CBO9781139026543.011

Chapter 9 - Gastrointestinal tract

from Part II - Oncologic applications

Published online by Cambridge University Press: 05 September 2012

Christiaan Schiepers

Edited by

Victor H. Gerbaudo

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Victor H. Gerbaudo: Affiliation:
Brigham and Women's Hospital, Harvard Medical School

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Summary

Introduction

In this chapter, the approach to gastrointestinal tumors will be discussed. Here we limitourselves to colorectal cancer (CRC), stomach or gastric cancer, and GIST (gastrointestinal stromaltumor) sarcoma. Chapter 8 expands on esophageal cancer. Pancreas, liver, and biliary tractmalignancies are discussed in Chapter 10.

Advances in diagnostic imaging technology have improved establishing the diagnosis, staging andrestaging of disease, and monitoring response to therapy. Various imaging modalities are availablefor this purpose, including the anatomical, e.g., radiography, computed tomography (CT), sonography(US), magnetic resonance imaging (MRI), and functional modalities such as molecular imaging,radioimmuno- and receptor scintigraphy, and magnetic resonance spectroscopy.

Conventional diagnostic methods have limited accuracy in early detection of primary as well asrecurrent CRC and gastric carcinoma. Assessment of disease extent or tumor burden is necessary forproper patient selection for surgery with curative intent, or stratification to chemotherapy and/orradiation treatment for patients with advanced disease. Appropriate non-invasive staging plays apivotal role in patient management. Integrated modalities such as positron emission tomography/computed tomography (PET/CT) have changed the current work-up of patients with cancer (1). Somerefer to these combined gantries as dual, multimodality or hybrid imaging systems.

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Type: Chapter
Information: A Case-Based Approach to PET/CT in Oncology , pp. 201 - 241

DOI: https://doi.org/10.1017/CBO9781139026543.011 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2012

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References

Schiepers, C.PET/CT in colorectal cancerJ Nucl Med 2003 44 1804Google Scholar PubMed

Landis, SHMurray, TBolden, SWingo, PA.Cancer statistics, 1999CA Cancer J Clin 1999 V49 8Google Scholar

Wingo, PARies, LAGRosenberg, HMMiller, DSEdwards, BKCancer incidence and mortality, 1973–1995: a report card for the U.SCancer 1998 V82 11973.0.CO;2-0>CrossRef Google Scholar

Jemal, ATiwari, RCMurray, TCancer statistics, 2004CA Cancer J Clin 2004 54 8CrossRef Google Scholar PubMed

Jemal, ASiegel, RWard, ECancer statistics, 2009CA Cancer J Clin 2009 59 225CrossRef Google Scholar PubMed

Coleman, RE.FDG imagingNucl Med Biol 2000 27 689CrossRef Google Scholar PubMed

Dahlbom, MHoffman, EJHoh, CKWhole-body positron emission tomography. 1. methods and performance characteristicsJ Nucl Med 1992 33 1191Google Scholar PubMed

Schiepers, CHoh, CK.Positron emission tomography as a diagnostic tool in oncologyEur Radiol 1998 8 1481CrossRef Google Scholar

Abdel-Nabi, HDoerr, RJLamonica, DMStaging of primary colorectal carcinomas with fluorine-18 fluorodeoxyglucose whole-body PET: correlation with histopathologic and CT findingsRadiology 1998 206 755CrossRef Google Scholar PubMed

Ruhlmann, JSchomburg, ABender, HFluorodeoxyglucose whole-body positron emission tomography in colorectal cancer patients studied in routine daily practiceDiseas Colon Rectum 1997 40 1195CrossRef Google Scholar PubMed

Huebner, RHPark, KCShepherd, JEA meta-analysis of the literature for whole-body FDG PET detection of recurrent colorectal cancerJ Nucl Med 2000 41 1177Google Scholar PubMed

Schiepers, CPenninckx, FDe Vadder, NContribution of PET in the diagnosis of recurrent colorectal cancer: comparison with conventional imagingEur J Surg Oncol 1995 21 517CrossRef Google Scholar

Moertel, CGFleming, TRMacDonald, JSAn evaluation of the carcinoembryonic antigen (CEA) test for monitoring patients with resected colon cancerJ Am Med Assoc 1993 270 943CrossRef Google Scholar PubMed

Charnley, RMImaging of colorectal carcinomaRadiology 1990 V174 283CrossRef Google Scholar

Steele, GBleday, RMayer, RJA prospective evaluation of hepatic resection for colorectal carcinoma metastases to the liver – Gastrointestinal-Tumor-Study-Group Protocol-6584J Clin Oncol 1991 V9 1105CrossRef Google Scholar

McDaniel, KPCharnsangavej, CDubrow, RAPathways of nodal metastasis in carcinomas of the cecum, ascending colon, and transverse colon – CT demonstrationAm J Roentgenol 1993 V161 61CrossRef Google Scholar

Nelson, RCChezmar, JLSugarbaker, PHBernardino, MEHepatic tumors-comparison of CT during arterial portography, delayed CT, and MR imaging for preoperative evaluationRadiology 1989 V172 27CrossRef Google Scholar

Sobhani, ITiret, ELebtahi, REarly detection of recurrence by 18FDG-PET in the follow-up of patients with colorectal cancerBr J Cancer 2008 98 875CrossRef Google Scholar PubMed

Votrubova, JBelohlavek, OJaruskova, MThe role of FDG-PET/CT in the detection of recurrent colorectal cancerEur J Nucl Med Mol Imaging 2006 33 779CrossRef Google Scholar PubMed

Warburg, O.On the origin of cancer cellsScience 1956 123 309CrossRef Google Scholar PubMed

Wahl, RL.Targeting glucose transporters for tumor imaging – sweet idea, sour resultJ Nucl Med 1996 V37 1038Google Scholar

Strauss, LG.Fluorine-18 deoxyglucose and false-positive results: a major problem in the diagnostics of oncological patientsEurJ Nucl Med 1996 23 1409CrossRef Google Scholar

Rosenbaum, SJLind, TAntoch, GBockisch, A.False-positive FDG PET uptake – the role of PET/CTEur Radiol 2006 16 1054CrossRef Google Scholar PubMed

Kamel, EMThumshirn, MTruninger, KSignificance of incidental 18F-FDG accumulations in the gastrointestinal tract in PET/CT: correlation with endoscopic and histopathologic resultsJ Nucl Med 2004 45 1804Google Scholar PubMed

Gutman, FAlberini, JLWartski, MIncidental colonic focal lesions detected by FDG PET/CTAm J Roentgenol 2005 185 495CrossRef Google Scholar PubMed

Kitajima, KMurakami, KYamasaki, EPerformance of integrated FDG PET/contrast-enhanced CT in the diagnosis of recurrent colorectal cancer: comparison with integrated FDG PET/non-contrast-enhanced CT and enhanced CTEur J Nucl Med Mol Imaging 2009 36 1388CrossRef Google Scholar

Cantwell, CPSetty, BNHolalkere, NLiver lesion detection and characterization in patients with colorectal cancer: a comparison of low radiation dose non-enhanced PET/CT, contrast-enhanced PET/CT, and liver MRIJ Comput Assist Tomogr 2008 32 738CrossRef Google Scholar PubMed

de Geus-Oei, LFVriens, Dvan Laarhoven, HWvan der Graaf, WTOyen, WJ.Monitoring and predicting response to therapy with 18F-FDG PET in colorectal cancer: a systematic reviewJ Nucl Med 2009 50 43SCrossRef Google Scholar PubMed

Rosenberg, RHerrmann, KGertler, RThe predictive value of metabolic response to preoperative radiochemotherapy in locally advanced rectal cancer measured by PET/CTInt J Colorectal Dis 2009 24 191CrossRef Google Scholar PubMed

Phelps, ME.Inaugural article: positron emission tomography provides molecular imaging of biological processesProc Natl Acad Sci US A 2000 97 9226CrossRef Google Scholar

Phelps, ME.PET: the merging of biology and imaging into molecular imagingJ Nucl Med 2000 41 661Google Scholar PubMed

Jadvar, HAlavi, AGambhir, SS18F-FDG uptake in lung, breast, and colon cancers: molecular biology correlates and disease characterizationJ Nucl Med 2009 50 1820CrossRef Google Scholar PubMed

Hoh, CKSchiepers, CSeltzer, MAPET in oncology: will it replace the other modalities?Semin Nucl Med 1997 27 94CrossRef Google Scholar PubMed

Goerres, GWHany, TFKamel, Evon Schulthess, GKBuck, A.Head and neck imaging with PET and PET/CT: artefacts from dental metallic implantsEur J Nucl Med Mol Imaging 2002 29 367CrossRef Google Scholar PubMed

Halpern, BSDahlbom, MWaldherr, CCardiac pacemakers and central venous lines can induce focal artifacts on CT-corrected PET imagesJ Nucl Med 2004 45 290Google Scholar PubMed

Halpern, BSDahlbom, MQuon, AImpact of patient weight and emission scan duration on PET/CT image quality and lesion detectabilityJ Nucl Med 2004 45 797Google Scholar PubMed

Goerres, GWBurger, CSchwitter, MWPET/CT of the abdomen: optimizing the patient breathing patternEur Radiol 2003 13 734Google Scholar PubMed

Strauss, LGClorius, JHSchlag, PRecurrence of colorectal tumors: PET evaluationRadiology 1989 170 329CrossRef Google Scholar PubMed

Takeuchi, OSaito, NKoda, KSarashina, HNakajima, N.Clinical assessment of positron emission tomography for the diagnosis of local recurrence in colorectal cancerBr J Surg 1999 86 932CrossRef Google Scholar

Strauss, LGConti, PS.The applications of PET in clinical oncologyJ Nucl Med 1991 V32 623Google Scholar

Findlay, MYoung, HCunningham, DNoninvasive monitoring of tumor metabolism using fluorodeoxyglucose and positron emission tomography in colorectal cancer liver metastases: correlation with tumor response to fluorouracil [see comments]J Clin Oncol 1996 14 700CrossRef Google Scholar

Akhurst, TLarson, SM.Positron emission tomography imaging of colorectal cancerSemin Oncol 1999 26 577Google Scholar PubMed

Folprecht, GGruenberger, TBechstein, WOTumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trialLancet Oncol 2010 11 38CrossRef Google Scholar PubMed

Haberkorn, UStrauss, LGDimitrakopoulou, APET studies of fluorodeoxyglucose metabolism in patients with recurrent colorectal tumors receiving radiotherapyJ Nucl Med 1991 32 1485Google Scholar PubMed

Schiepers, CHaustermans, KGeboes, KThe effect of preoperative radiation therapy on glucose utilization and cell kinetics in patients with primary rectal carcinomaCancer 1999 85 8033.0.CO;2-T>CrossRef Google Scholar PubMed

Young, HBaum, RCremerius, UMeasurement of clinical and subclinical tumour response using [F-18]-fluorodeoxyglucose and positron emission tomography: review and 1999 EORTC recommendationsEur J Cancer 1999 V35 1773CrossRef Google Scholar

Shankar, LKHoffman, JMBacharach, SConsensus recommendations for the use of 18F-FDG PET as an indicator of therapeutic response in patients in National Cancer Institute TrialsJ Nucl Med 2006 47 1059Google Scholar PubMed

Delbeke, DColeman, REGuiberteau, MJProcedure guideline for tumor imaging with 18F-FDG PET/CT 1.0J Nucl Med 2006 47 885Google Scholar PubMed

Dassen, AELips, DJHoekstra, CJPruijt, JFBosscha, K.FDG-PET has no definite role in preoperative imaging in gastric cancerEur J Surg Oncol 2009 35 449CrossRef Google Scholar PubMed

Stahl, AOtt, KWeber, WAFDG PET imaging of locally advanced gastric carcinomas: correlation with endoscopic and histopathological findingsEur J Nucl Med Mol Imaging 2003 30 288CrossRef Google Scholar PubMed

Sun, LSu, XHGuan, YSClinical role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography in post-operative follow up of gastric cancer: initial resultsWorld J Gastroenterol 2008 14 4627CrossRef Google Scholar PubMed

Sim, SHKim, YJOh, DYThe role of PET/CT in detection of gastric cancer recurrenceBMC Cancer 2009 9CrossRef Google Scholar PubMed

Kim EY Lee, WJChoi, DThe value of PET/CT for preoperative staging of advanced gastric cancer: comparison with contrast-enhanced CTEur J Radiol 2011 79 183CrossRef Google Scholar

Kwee, RMKwee, TC.Imaging in assessing lymph node status in gastric cancerGastric Cancer 2009 12 6CrossRef Google Scholar PubMed

Ott, KFink, UBecker, KPrediction of response to preoperative chemotherapy in gastric carcinoma by metabolic imaging: results of a prospective trialJ Clin Oncol 2003 21 4604CrossRef Google Scholar PubMed

Ott, KHerrmann, KLordick, FEarly metabolic response evaluation by fluorine-18 fluorodeoxyglucose positron emission tomography allows in vivo testing of chemosensitivity in gastric cancer: long-term results of a prospective studyClin Cancer Res 2008 14 2012CrossRef Google Scholar PubMed

Esteves, FPSchuster, DMHalkar, RK.Gastrointestinal tract malignancies and positron emission tomography: an overviewSemin Nucl Med 2006 36 169CrossRef Google Scholar PubMed

Goerres, GWStupp, RBarghouth, GThe value of PET, CT and in-line PET/CT in patients with gastrointestinal stromal tumours: long-term outcome of treatment with imatinib mesylateEur J Nucl Med Mol Imaging 2005 32 153CrossRef Google Scholar PubMed

Antoch, GKanja, JBauer, SComparison of PET, CT, and dual-modality PET/CT imaging for monitoring of imatinib (STI571) therapy in patients with gastrointestinal stromal tumorsJ Nucl Med 2004 45 357Google Scholar PubMed

Pisters, PWPatel, SRGastrointestinal stromal tumors: current managementJ Surg Oncol 2010 102 530CrossRef Google Scholar PubMed

Van den Abbeele, AD.The lessons of GIST – PET and PET/CT: a new paradigm for imagingOncologist 2008 13 8CrossRef Google Scholar PubMed

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