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97 - Dural Venous Sinus Thrombosis

from Section 4 - Abnormalities Without Significant Mass Effect

Published online by Cambridge University Press:  05 August 2013

Giulio Zuccoli
Affiliation:
University of Pittsburgh Medical Center
Zoran Rumboldt
Affiliation:
Medical University of South Carolina
Mauricio Castillo
Affiliation:
University of North Carolina, Chapel Hill
Benjamin Huang
Affiliation:
University of North Carolina, Chapel Hill
Andrea Rossi
Affiliation:
G. Gaslini Children's Research Hospital
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Summary

Specific Imaging Findings

Increased density in the occluded sinus leading to a “cord sign” is the classic imaging finding of dural venous sinus thrombosis (DVST) on unenhanced CT images. However, a high variability in the degree of thrombus density is responsible for a low sensitivity of this sign. Thus, evaluation with CT angiogram, MR and MRV may be required to confirm the diagnosis. The “empty delta” sign consisting of a triangular area of enhancement with a relatively low-density center is seen in 25-30% of cases on contrast-enhanced CT scans. On MRI, acute thrombus is T1 isointense, T2 and T2* hypoin-tense. Of note, this T2 hypointensity may mimic normal flow-void. Peripheral enhancement is seen around the acute hypointense clot corresponding to the empty delta CT sign. Subacute thrombus becomes T1 and T2 hyperintense. Chronic thrombus is most commonly T1 isointense and T2 hyperin-tense. DWI/ADC signal of the thrombus is variable, as is the degree of enhancement in organized thrombus. Visible serpiginous intrathrombus flow-voids on T2WI, corresponding areas of flow signal on TOF-MRV, and brightly enhancing channels on post-contrast MRV are present in most cases of chronic partial recanalization. Thrombosis shows no flow-related signal on phase contrast MRV, and absent to diminished enhancement on post contrast MRV and CTV. Engorged collateral veins may be present, primarily in the chronic phase. TOF-MRV of a subacute T1 bright clot may potentially misrepresent sinus patency.

Type
Chapter
Information
Brain Imaging with MRI and CT
An Image Pattern Approach
, pp. 201 - 202
Publisher: Cambridge University Press
Print publication year: 2012

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References

1. Leach, JL, Fortuna, RB, Jones, BV, Gaskill-Shipley, MF. Imaging of cerebral venous thrombosis: current techniques, spectrum of findings, and diagnostic pitfalls. Radiographics 2006;26(Suppl 1):S19–41.CrossRefGoogle ScholarPubMed
2. Meckel, S, Reisinger, C, Bremerich, J, et al. Cerebral venous thrombosis: diagnostic accuracy of combined, dynamic and static, contrast-enhanced 4D MR venography. AJNR 2010;31:527–35.CrossRefGoogle ScholarPubMed
3. Leach, JL, Wolujewicz, M, Strub, WM. Partially recanalized chronic dural sinus thrombosis: findings on MR imaging, time-of-flight MR venography, and contrast-enhanced MR venography. AJNR 2007;28:782–9.Google ScholarPubMed
4. Oppenheim, C, Domingo, V, Gauvrit, JY, et al. Subarachnoid hemorrhage as the initial presentation of dural sinus thrombosis. AJNR 2005;26:614–7.Google ScholarPubMed
5. Dentali, F, Squizzato, A, Gianni, M, et al. Safety of thrombolysis in cerebral venous thrombosis. A systematic review of the literature. Thromb Haemost 2010;104:1055–62.Google ScholarPubMed

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