8 - Multiscale modeling
the future
Published online by Cambridge University Press: 05 January 2012
Summary
An analysis of the conditions required before the full integrative multiscale modeling vision can be embraced in full.
Introduction
In spite of its title, so far this book has mostly described how to model the human skeleton at a given scale. Only Chapter 7 described two clinical applications where models defined at multiple scales are combined to provide a reliable prediction of an otherwise complex process. But even in these examples, single-scale models were somehow patched together, without providing a clear general approach to multiscale modeling.
This is not a mistake, or an omission. The fact is, as explained in Chapter 1, that multiscale modeling is not a fully established reality yet, but rather a vision and a work-in-progress. The vision of representing human physiology and pathology as a concatenation of predictive and mechanistic models defined at different scales (the physiome) was proposed a while ago; but the concrete development of a framework of methods and technologies that make such a modeling approach feasible (the Virtual Physiological Human) has only just started, and, to date, none of the research projects that aim to develop portions of it has been completed.
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- Multiscale Modeling of the Skeletal System , pp. 173 - 195Publisher: Cambridge University PressPrint publication year: 2011
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