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Type 2 diabetes prevention: genetic association analysis of dried fruit intake and disease risk

Published online by Cambridge University Press:  28 October 2024

Liya Gong Open the ORCID record for Liya Gong [Opens in a new window] ,
Ziqi Wu ,
Liaoming Gao ,
Junyan Wen ,
Xuecong Lin  and
Ge Wen
Liya Gong
Affiliation:
Department of Imaging Diagnostics, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
Ziqi Wu
Affiliation:
Department of Imaging Diagnostics, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
Liaoming Gao
Affiliation:
Department of Imaging Diagnostics, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
Junyan Wen
Affiliation:
Department of Imaging Diagnostics, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
Xuecong Lin
Affiliation:
Department of Imaging Diagnostics, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
Ge Wen*
Affiliation:
Department of Imaging Diagnostics, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
*
*Corresponding author: Ge Wen, email wenge@smu.edu.cn
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Abstract

Prior research has suggested an inverse correlation between dried fruit intake and type 2 diabetes mellitus (T2DM), yet the causal link remains uncertain. This study seeks to investigate the potential causal impact of dried fruit intake on T2DM, covering cases both with and without various complications, as well as glycaemic traits, using a two-sample Mendelian randomisation (MR) approach. Using MR analysis with genome-wide association study summary statistics, the primary analysis investigated the causal relationship between dried fruit intake and T2DM, both with and without complications, as well as glycaemic traits, employing the inverse variance weighted method. Supplementary analyses were conducted using MR-Egger and the weighted median method. Heterogeneity and intercept tests were utilised to evaluate the robustness of the study outcomes. The results show a significant association between dried fruit intake and T2DM without complications, as well as fasting insulin. Sensitivity analyses confirmed the robustness of the results and the independence from multicollinearity. However, no association was found between dried fruit intake and T2DM with various complications or other glycaemic traits. The significant association between dried fruit intake and T2DM without complications and fasting insulin persisted even after adjusting for BMI. This study offers genetic evidence endorsing the protective effects of dried fruit intake against T2DM, specifically for cases without complications, and in regulating fasting insulin. These findings suggest that dried fruit intake might serve as a primary preventive strategy for T2DM.

Keywords

Mendelian randomisationDried fruit intakeType 2 diabetesGlycaemic traitsGenetic variants
Type
Research Article
Information
British Journal of Nutrition , Volume 132 , Issue 8 , 28 October 2024 , pp. 988 - 995
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Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society

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