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A detailed profile of cognitive dysfunction and its relation to psychological distress in patients with type 2 diabetes mellitus

Published online by Cambridge University Press:  02 February 2007

AUGUSTINA M.A. BRANDS ,
ESTHER VAN DEN BERG ,
SANNE M. MANSCHOT ,
GEERT JAN BIESSELS ,
L. JAAP KAPPELLE ,
EDWARD H.F. DE HAAN  and
ROY P.C. KESSELS
AUGUSTINA M.A. BRANDS
Affiliation:
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands Neuropsychology, Zuwe Hofpoort/Regional Psychiatric Center, Woerden, The Netherlands Helmholtz Instituut, Department of Experimental Psychology, Utrecht University, Utrecht, The Netherlands
ESTHER VAN DEN BERG
Affiliation:
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
SANNE M. MANSCHOT
Affiliation:
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
GEERT JAN BIESSELS
Affiliation:
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
L. JAAP KAPPELLE
Affiliation:
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
EDWARD H.F. DE HAAN
Affiliation:
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands Helmholtz Instituut, Department of Experimental Psychology, Utrecht University, Utrecht, The Netherlands
ROY P.C. KESSELS
Affiliation:
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands Departments of Medical Psychology and Geriatrics, Radboud University Nijmegen Medical Centre, The Netherlands NICI, Neuropsychology and Rehabilitation, Radboud University Nijmegen, The Netherlands
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Abstract

Type 2 diabetes mellitus (DM2) is a common metabolic disorder. DM2 is associated with cognitive impairments, and with depressive symptoms, which occur in about one third of patients. In the current study we compared the cognitive profile and psychological well-being of 119 patients with DM2 (mean age: 66 ± 6; mean duration: 9 ± 6 years) with 55 age and education matched-control participants. Groups were compared on cognitive performance in five major cognitive domains, psychological wellbeing [assessed by Symptom Checklist (SCL)-90-R and the Beck Depression Inventory (BDI-II)] and abnormalities on brain MRI. We hypothesized an interrelationship between cognition, MRI abnormalities, and psychological well-being. DM2 patients performed significantly worse than controls on cognitive tasks, especially on tasks that required more mental efficiency, although the differences were modest (effect sizes Cohen d < .6). We speculate that DM2 patients have a diminished ability to efficiently process unstructured information. Patients with DM2 had significantly higher scores on the SCL-90-R (p < .001) and on the BDI-II (p < .001) and worse MRI ratings than controls, but psychological distress did not correlate with cognition, MRI ratings or biomedical characteristics. Contrary to our hypothesis, cognitive disturbances and psychological distress thus seem independent symptoms of the same disease. (JINS, 2007, 13, 288–297.)

Keywords

InsulinDepressionAgingBrain MRINeuropsychologicalAssessment

Information

Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 13 , Issue 2 , March 2007 , pp. 288 - 297
Copyright
© 2007 The International Neuropsychological Society

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