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Strategy Use, Planning, and Rule Acquisition Deficits in Spinocerebellar Ataxia Type 2 Patients

Published online by Cambridge University Press:  23 March 2015

Israel Vaca-Palomares ,
Rosalinda Díaz ,
Roberto Rodríguez-Labrada ,
Jacqueline Medrano-Montero ,
Raúl Aguilera-Rodríguez ,
Yaimeé Vázquez-Mojena ,
Juan Fernandez-Ruiz  and
Luis Velázquez-Pérez
Israel Vaca-Palomares
Affiliation:
Laboratory of Neuropsychology, Department of Physiology, Faculty of Medicine, National Autonomous University of Mexico, Coyoacan, Mexico City 04510, Mexico City, Mexico
Rosalinda Díaz
Affiliation:
Laboratory of Neuropsychology, Department of Physiology, Faculty of Medicine, National Autonomous University of Mexico, Coyoacan, Mexico City 04510, Mexico City, Mexico
Roberto Rodríguez-Labrada
Affiliation:
Centre for the Investigation and Rehabilitation of Hereditary Ataxias, Holguin, Cuba
Jacqueline Medrano-Montero
Affiliation:
Centre for the Investigation and Rehabilitation of Hereditary Ataxias, Holguin, Cuba
Raúl Aguilera-Rodríguez
Affiliation:
Centre for the Investigation and Rehabilitation of Hereditary Ataxias, Holguin, Cuba
Yaimeé Vázquez-Mojena
Affiliation:
Centre for the Investigation and Rehabilitation of Hereditary Ataxias, Holguin, Cuba
Juan Fernandez-Ruiz
Affiliation:
Laboratory of Neuropsychology, Department of Physiology, Faculty of Medicine, National Autonomous University of Mexico, Coyoacan, Mexico City 04510, Mexico City, Mexico Faculty of Psychology, University of Veracruz, Xalapa, Veracruz, Mexico
Luis Velázquez-Pérez*
Affiliation:
Centre for the Investigation and Rehabilitation of Hereditary Ataxias, Holguin, Cuba
*
Correspondence and reprint requests to: Velázquez-Pérez Luis, Carretera central km 51/12 Vía Habana. Reparto Edecio Pérez, Holguín. Postal code: 80100. E-mail: velazq63@gmail.com
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Abstract

Our goal was to improve spinocerebellar ataxia type 2 (SCA2) cognitive profile characterization by testing the hypothesis that strategy, planning and rule acquisition capacities are affected in SCA2. Forty one patients with SCA2 were evaluated with the Spatial Working Memory (SWM), the Stockings of Cambridge (SOC), and the Intra-Extra Dimensional Shift (IED) tests of the Executive module of the Cambridge Neuropsychological Testing Automated Battery (CANTAB). Paired Associates Learning (PAL) and Delayed Matching to Sample (DMS) from the CANTAB memory module were also assessed to corroborate previous findings. Motor deterioration was measured using the Scale for the Assessment and Rating of Ataxia (SARA). We found significant SCA2 related deficits in strategy, planning, and rule acquisition. Our results also corroborated significant memory deficits in these patients with SCA2. Further analysis also showed that patients with large motor deterioration had poorer associative learning and spatial planning scores. Patients with SCA2 show strategy, planning, and rule acquisition deficits as revealed with the CANTAB battery. These deficits should be noted when planning an effective therapy for these patients. (JINS, 2015, 21, 1–7)

Keywords

SCA2Cognitive deficitsExecutive functionsAttentionMotor deteriorationCANTAB

Information

Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 21 , Issue 3 , March 2015 , pp. 214 - 220
Copyright
Copyright © The International Neuropsychological Society 2015 

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