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This chapter explores three particular circumstances where integrity has been found to be breached in tennis, namely doping, match-fixing and other less serious offenses, such as failure to report or failure to cooperate. The chapter goes on to explain anti-doping jurisprudence in tennis, the nature of proceedings, the relevant burden of proof and the intricacies of “intent” and “fault,” as well as the standard of “no fault or negligence” and “no significant fault or negligence.” The section on anti-corruption examines match-fixing by athletes and third parties, and also by umpires and other officials, as well as the sanctions imposed under relevant rules. These offenses are typically associated with legitimate betting and may involve money laundering and other non-predicate offenses.
A poet celebrated for his syncretism, Shelley’s sense of fluidity arguably extends to his understanding of sex and sexuality, as he wrote during a time of peak flexibility and transition in thinking about gender-sex. Reading Erasmus Darwin’s descriptions of variously sexed plants, Ovid’s tales of shapeshifting, and William Lawrence’s intertwinement of sexed and racialised bodies, Shelley, the great poet of relation, comes to see the body as materially shifting, porous, and relational. Reading passages from A Discourse on the Manners of the Ancient Greeks Relative to the Subject of Love alongside the figure of nonbinary, intersex creation in ‘The Witch of Atlas’, Asia’s transformation into the posthuman ‘lamp of light’, and the nonhuman ‘shape all light’ in ‘The Triumph of Life’, this essay suggests Shelley began to understand polymorphous sexuality connected to sexed bodies of shapeshifting, mutable morphology.
Objectives/Goals: The purpose of this study was to document the publicly available literature, measurement tools, secondary data, and expert perspective on the intersectional care gaps and disparities of children with palliative needs in foster care. Methods/Study Population: Four data collection methods determined the frontier of available information on the palliative needs of children in foster care. A literature review assessed the quality and content of published evidence. A catalogue of relevant measures tools and validation results determined what psychometric tools exist for the population, how well they performed in validation studies, and if any incorporated community members in their development. The National Data Archive for Child Abuse and Neglect was consulted to assess whether existing secondary data was fit for purpose. Informal interviews will be conducted with subject matter experts (pediatrics, palliative care, foster care) to determine the legitimacy and urgency of the problem. Results/Anticipated Results: Health inequities among children in foster care and children with medical complexity (CMC) suggest a strong likelihood of unmet palliative care needs for CMC in foster care; however, no literature or data describe the scope and severity, and few insights support development of safe and supportive interventions to meet these needs. No national publicly available datasets include both foster-related case or placement information and diagnosis or service-specific data, including Medicaid data and the Adoption and Foster Care Analysis and Reporting System (AFCARS). No work has been published integrating foster parents or former foster youth input on palliative needs. Participatory action research methodologies with critically ill patients have led to improvements in patient experience and clinical care. Discussion/Significance of Impact: The lack of data, community engagement, and validated measures to identify palliative needs of children in foster care stymie efforts to identify and correct health inequities. Participatory action research is needed to meaningfully engage foster and health care partners to determine what palliative care needs should be prioritized and measured.
Objectives/Goals: This study investigates the contribution of the stool secretome (the soluble factors secreted by microbes into extracellular space) to in vitro α-synuclein (αSyn) oligomerization using stool cultures from patients with multiple system atrophy (MSA), a rare neurodegenerative disease hallmarked by pathologic αSyn aggregates. Methods/Study Population: Stool samples from MSA patients (n = 20), household controls (n = 20), and healthy controls (n = 20) will be cultured using an adapted dilution-to-extinction approach. The goal is to reduce microbial complexity progressively to produce random secretome combinations that may affect αSyn oligomerization differentially. The original inoculant and dilutions will be cultured anaerobically to collect conditioned media (CM) enriched with microbial secretomes. CM will be used to expose a fluorescence resonance energy transfer (FRET) biosensor assay and a Gaussia luciferase protein complementation assay – both modified to quantify αSyn-αSyn interaction indicating oligomerization. Any CM-altering αSyn oligomerization will undergo multiomic characterization to identify potential causative agent(s). Results/Anticipated Results: Specific microbe-produced molecules from the literature are anticipated to modulate αSyn oligomerization, identified by targeted, reductionist studies that selected and tested separately single microbial factors on αSyn aggregation in vitro and in vivo. From these studies, lipopolysaccharide and bacterial amyloid protein are expected to increase αSyn oligomerization, while short-chain fatty acids, such as butyrate, are expected to interfere with and decrease oligomerization. As a complementary systemic approach, this study’s agnostic methods involving MSA stool culture combined with the proposed dilution-to-extinction method are expected to identify additional MSA stool secretome components modulating αSyn oligomerization that might otherwise be missed in earlier reductionist approaches. Discussion/Significance of Impact: Completion of this reverse-translational work will aid in discovering MSA stool secretome components modulating αSyn oligomerization. Identification of specific factors contributing to pathologic αSyn behavior might set the stage for patient screenings for identified stool markers and could lead to microbiome-based interventions for MSA.
Populists emerge when distrust of state institutions or dissatisfaction with democracy convince voters that claims about conspiring elites blocking the general will are valid. We propose that these dynamics change when populists are incumbents; once they command institutions, their sustained support becomes contingent upon trust in the new institutional order, and they are held accountable for making people think democracy is working well. Newly collected data on party populism and survey data from Latin America show that support for populist parties in the region is conditioned by satisfaction with democracy as well as the incumbency status of populists. Dissatisfied voters support populist opposition parties, but support for populist incumbents is higher among those satisfied with democracy and its institutions. While democratic deficits and poor governance provide openings for populists, populists are held accountable for institutional outcomes.
This interview with Peter Singer AI serves a dual purpose. It is an exploration of certain—utilitarian and related—views on sentience and its ethical implications. It is also an exercise in the emerging interaction between natural and artificial intelligence, presented not as just ethics of AI but perhaps more importantly, as ethics with AI. The one asking the questions—Matti Häyry—is a person, in the contemporary sense of the word, sentient and self-aware, whereas Peter Singer AI is an artificial intelligence persona, created by Sankalpa Ghose, a person, through dialogue with Peter Singer, a person, to programmatically model and incorporate the latter’s writings, presentations, recipes, and character qualities as a renowned philosopher. The interview indicates some subtle differences between natural perspectives and artificial representation, suggesting directions for further development. PSai, as the project is also known, is available to anyone to chat with, anywhere in the world, on almost any topic, in almost any language, at www.petersinger.ai
In this chapter, we are interested in how AI may enhance our well-being – or do the opposite. A defintion of well-being and promotion of core vlaues will be discussed. It will then survey AI technologies and assess whether they enhance or diminish human well-being, using the different meanings of well-being
Despite governors’ crucial roles in shaping important policies, including abortion, education, and infrastructure, forecasters have paid little attention to gubernatorial elections. We posit that institutional idiosyncrasies and lack of public opinion data have exacerbated the classic problem facing all election forecasts: there are too many predictors and too few cases, leading to overfitting. To address these problems, we combine new governor and state-level presidential approval data with a machine-learning approach, LASSO, for variable selection. LASSO examines numerous variables but retains only those that substantively improve model performance. Results demonstrate the efficacy of gubernatorial and presidential approval ratings measured two quarters preelection in predicting both incumbent-party vote share and election winners in out-of-sample predictions. For 2022, our approach outperformed the Cook Political Report’s Partisan Voting Index and compared well with 538’s Election Day prediction. For 2024, our LASSO-Popularity model predictions indicate that it will likely be a difficult year for Democrats in gubernatorial contests.
In January 1935, Palestinian Islamic thinkers, in conversation with counterparts elsewhere in the Middle East and South Asia, concluded that those who sold or facilitated the sale of land to the Mandate Jewish community must be excommunicated. This article explores the emergence of such religious excommunication (takfīr) in Mandate Palestine between 1929 and 1935 based on a wide range of periodicals and pamphlets from this period. It argues that, far from a story of an underlying “Islamic radicalism” which reemerged in a time of pressure, this is a case in which internal and external political and economic pressures necessitated a drastic solution which could distinguish Muslims committed to the Palestinian nationalist project from those who were not. In doing so, the article contributes to scholarship on both Modern Islam and Mandate Palestine.
Ecosystem structure and functioning is the focus of much ecological research because many ecosystem properties such as production, energy flow, nutrient cycles, and stability lie at the core of understanding ecological processes. Net primary production (NPP) is primarily influenced by climate and nutrients. On a global scale, NPP in terrestrial biomes tends to be greatest near the tropics, where the combination of constant and moderately high temperature and adequate rainfall promote plant growth. NPP in marine biomes peaks at about 40° S latitude, which is associated with large areas of upwelling and high nutrient availability. On a regional and local scale, the availability of nutrients such as nitrogen and phosphorus influence terrestrial, marine, and freshwater production. Ecosystem structure is based on the interactions between producers, consumers, detritivores, and decomposers. A substantial but variable amount of energy is lost with each transfer from one trophic level to the level above, which has the effect of limiting food chain length (FCL). In some aquatic systems, longer food chains are associated with CO2 export from the water into the atmosphere, and with the biomagnification of toxic substances.
Anthropologist Richard Leakey sent Jane Goodall to Gombe (now Gombe Stream National Park) to study chimpanzees in the wild. As an anthropologist, he was keenly interested in human behavior, and believed that chimpanzees would provide a window to understanding it. It took Goodall six months of crawling around in the woods before any chimpanzees would allow her to get close enough to observe them. But her persistence paid off, as she was able to document chimpanzees showing some very human behavior including tool making, cooperative hunting and war making. Partway through her career, she elected to devote the rest of her career to environmental activism and education, and Gombe research was continued by a growing community of researchers including her student, Anne Pusey. Pusey was fascinated by mother–infant relationships, by developmental changes in juveniles as they matured, and by how chimpanzees manage to avoid breeding with close relatives. Other researchers at Gombe studied the relationship between rank and reproductive success, and how disease was influencing survival rates in three different populations in the region. Unfortunately, life table studies indicate that disease and a lack of immigrants into the region are threatening the viability of this iconic group of chimpanzees.
A species’ behavioral, developmental, and reproductive life history will influence how quickly it can recover after a population crash. Some species can recover very quickly, while others, such as the North Atlantic right whale, cannot recover quickly, because even under ideal conditions they develop slowly and have very low reproductive rates. Ecologists have described various life history classification schemes that identify important tradeoffs in resource allocation, and focus attention on interesting life history questions. The quantitative relationship between metabolic rate and body size can help ecologists understand some life history tradeoffs, such as the relationship between number and size of offspring. There is a fundamental tradeoff between parental investment in any one reproductive event and the number of lifetime reproductive events, which in some cases can lead to a semelparous reproductive life history. Variable environments can select for phenotypic plasticity, which can lead to organisms with similar genotypes expressing alternative behavioral, developmental or reproductive life history traits. In some cases, phenotypic plasticity may help species adjust to rapidly changing environmental conditions, including climate change.
Organisms may compete for a great variety of limiting resources, such as food and habitat and, in the case of plants, light and pollinators. Direct mechanisms of competition, as highlighted by interactions between yellow crazy ants and hermit crabs on Tokelau, include resource and interference competition, while indirect mechanisms of competition that are mediated by other species are also widespread in ecological communities. Introductions of species into novel environments allow ecologists to study competitive interactions in real time. Interspecific competition can lead to competitive exclusion when two or more species occupy similar niches. A variable environment, niche shift, and niche partitioning can promote species coexistence. Theoretical models, such as the Lotka–Volterra competition model, help identify conditions in which two or more competing species can coexist. When conservation ecologists introduce two or more species as biological control agents, they must consider potential competitive interactions among the introduced species, keeping in mind the factors that promote the coexistence of the introduced species.
Humans have profoundly changed nutrient cycles on a global, regional, and local level. Agricultural runoff carrying heavy loads of nitrogen and phosphorus compounds caused eutrophication of the Black Sea. This led to a series of events that culminated in the annual formation of a dead zone within the Black Sea, and the consequent loss of biological diversity of several trophic levels. The nitrogen cycle depends heavily on the activities of microorganisms to fix nitrogen, and to transform nitrogen in the processes of nitrification, ammonification, denitrification, and anammox. Technological advances such as the Haber–Bosch process have vastly increased the amount of reactive nitrogen entering ecosystems, leading to increases in agricultural production, but also polluting many aquatic systems. The phosphorus cycle is similar to the nitrogen cycle, in that globally there are vast stores of phosphorus compounds, but most of it is inaccessible to organisms. In contrast to the nitrogen cycle, there is only a small atmospheric component to the phosphorus cycle; most phosphorus becomes available through weathering of rocks. Both nutrient cycles are similar in one very important way; nitrogen and phosphorus are recycled many times between organisms and the environment before exiting an ecosystem.
Dan Janzen and Winnie Hallwachs, his wife and colleague, have spent two lifetimes studying ecological interactions between organisms, mostly at Area de Conservacion Guanacaste (ACG) in northwestern Costa Rica. Early in his career, Janzen investigated many basic questions in evolutionary community ecology. One study of plant reproductive success and life history strategies showed that legume species use one of two alternative strategies to reproduce successfully – producing huge numbers of tiny defenseless seeds or small numbers of large, well-defended seeds. A second study explained high biological diversity in rainforests as arising because baby plants survive poorly near their parents (because seed predators consume them there), and only become established a considerable distance away from them. He also emphasizes that current selection pressures may differ from historical pressures, so it is critical to understand ecosystems in the context of their evolutionary history. Both Janzen and Hallwachs have now shifted their focus to inventorying the diversity of Lepidoptera, their parasitoids and host plants at ACG, so that their complex interactions can be understood by researchers and by students who use ACQ as a natural classroom.