The arrest of Thomas Cromwell in June 1540 and his inescapable execution on 28 July offered a chance for the Catholic powers of Christendom to hope and work for the end of the English schism. In 1540, Charles V proposed colloquies between the different confessions in his empire and in the same spirit conceived an alliance with Henry VIII. Both Charles and Henry practised to deceive, but two mysterious Imperial missions to England in July 1540, which the removal of Cromwell made possible, and the manner of Henry’s welcome of them, provide proof of the seriousness of their intent. The brief period between Cromwell’s arrest and his death was exploited by both Henry VIII and European powers to attempt reconciliation, or, at least, to temporize. This article analyses complex diplomatic reports to show how Cromwell’s fall assumed significance far beyond England, as new evidence of an abrupt realignment at a climacteric of European dynastic politics and Reformation diplomacy reveals.