Observations of the 21 cm signal face significant challenges due to bright astrophysical foregrounds that are several orders of magnitude higher than the brightness of the hydrogen line, along with various systematics. Successful 21 cm experiments require accurate calibration and foreground mitigation. Errors introduced during the calibration process such as systematics can disrupt the intrinsic frequency smoothness of the foregrounds, leading to power leakage into the Epoch of Reionisation window. Therefore, it is essential to develop strategies to effectively address these challenges. In this work, we adopt a stringent approach to identify and address suspected systematics, including malfunctioning antennas, frequency channels corrupted by radio frequency interference, and other dominant effects. We implement a statistical framework that utilises various data products from the data processing pipeline to derive specific criteria and filters. These criteria and filters are applied at intermediate stages to mitigate systematic propagation from the early stages of data processing. Our analysis focuses on observations from the Murchison Widefield Array Phase I configuration. Out of the observations processed by the pipeline, our approach selects 18%, totalling 58 h, that exhibit fewer systematic effects. The successful selection of observations with reduced systematic dominance enhances our confidence in achieving 21 cm measurements.

OBJECTIVES/GOALS: To facilitate the development of innovative injection products by providing translational researchers with a regulatory and manufacturing road map for producing small batch sterile products for Phase 1 research use. To leverage recent AMC investments in facility improvements and pharmacy training in the areas of sterile product production, testing, and environmental controls, that can be used to support production of phase 1 clinical trial supplies METHODS/STUDY POPULATION: Searching and organizing relevant data and information from web portals and databases in the following: areas: FDA, EMA, USP regulations, regulatory science, pharmaceutical formulation and analytics, supply vendors, analytical testing laboratories, and product testing laboratories. Present the information using a user friendly format including flow charts and development timelines, taking the perspective of the translational investigator. RESULTS/ANTICIPATED RESULTS:

• Choosing AMC resources vs outside consultants and vendors, leveraging local resources where possible

• Qualifying and monitoring suppliers, testing laboratories, in-house departments, and Contract Drug Manufacturing Organizations (CDMO)

• Bringing together the deliverables for the IND CMC section

• Where and how to leverage available products and science to simplify safe and reliable production

DISCUSSION/SIGNIFICANCE OF IMPACT: Use and utility of injectable drug products, both small molecule and biologics, is growing rapidly, and is projected to continue to escalate well into the next decade. This is due not only to advances in medicine, but also to improvements in AMC-based sterile product production, and a better understanding of small batch manufacturing methods. All three trends align in academic medical centers (AMC) and can be utilized by translational researchers, if they can understand the potential and regulatory requirements.

Contact metamorphism in the aureole of the Easky adamellite produced andalusite at the expense of regional staurolite, kyanite, and garnet. In the inner aureole sillimanite and K-feldspar also grew. Cordierite is only rarely present. Conditions of metamorphism in the inner aureole have been deduced from five independent criteria as 595 ± 30 °C and 2.5 ± 0.5kb. The nearby Lough Talt adamellite was emplaced at slightly higher pressures. Some aureole rocks have undergone oxidation with conversion of regional garnet to magnetite and andalusite. The reacting assemblage buffered ƒ O 2 near 10−17 bars. It is inferred that oxidation was caused by movement of H2O from the country rocks into the intrusion.

Why has Australia not followed Canada, New Zealand and the United Kingdom in adopting a formal bill of rights at the national level? We argue that the Australian Constitution has made the difference. The Constitution has underpinned a comparatively strong parliamentary check on the executive, weakening the rationale for a bill of rights and impeding legislative initiatives towards this end; thwarted the drive for a constitutional bill of rights; and helped delegitimize statutory approaches to a bill of rights in general and the “dialogue model” in particular. The article ultimately questions the notion that a common approach to rights protection can apply across Westminster democracies.