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The First Large Absorption Survey in H i (FLASH) is a large-area radio survey for neutral hydrogen in and around galaxies in the intermediate redshift range $0.4\lt z\lt1.0$, using the 21-cm H i absorption line as a probe of cold neutral gas. The survey uses the ASKAP radio telescope and will cover 24,000 deg$^2$ of sky over the next five years. FLASH breaks new ground in two ways – it is the first large H i absorption survey to be carried out without any optical preselection of targets, and we use an automated Bayesian line-finding tool to search through large datasets and assign a statistical significance to potential line detections. Two Pilot Surveys, covering around 3000 deg$^2$ of sky, were carried out in 2019-22 to test and verify the strategy for the full FLASH survey. The processed data products from these Pilot Surveys (spectral-line cubes, continuum images, and catalogues) are public and available online. In this paper, we describe the FLASH spectral-line and continuum data products and discuss the quality of the H i spectra and the completeness of our automated line search. Finally, we present a set of 30 new H i absorption lines that were robustly detected in the Pilot Surveys, almost doubling the number of known H i absorption systems at $0.4\lt z\lt1$. The detected lines span a wide range in H i optical depth, including three lines with a peak optical depth $\tau\gt1$, and appear to be a mixture of intervening and associated systems. Interestingly, around two-thirds of the lines found in this untargeted sample are detected against sources with a peaked-spectrum radio continuum, which are only a minor (5–20%) fraction of the overall radio-source population. The detection rate for H i absorption lines in the Pilot Surveys (0.3 to 0.5 lines per 40 deg$^2$ ASKAP field) is a factor of two below the expected value. One possible reason for this is the presence of a range of spectral-line artefacts in the Pilot Survey data that have now been mitigated and are not expected to recur in the full FLASH survey. A future paper in this series will discuss the host galaxies of the H i absorption systems identified here.
Rooted in an international political economy theoretical framework, this book provides unique insights into the global forces and local responses that are shaping education systems in Central America and the Latin Caribbean (CALC).
In response to the COVID-19 pandemic, we rapidly implemented a plasma coordination center, within two months, to support transfusion for two outpatient randomized controlled trials. The center design was based on an investigational drug services model and a Food and Drug Administration-compliant database to manage blood product inventory and trial safety.
Methods:
A core investigational team adapted a cloud-based platform to randomize patient assignments and track inventory distribution of control plasma and high-titer COVID-19 convalescent plasma of different blood groups from 29 donor collection centers directly to blood banks serving 26 transfusion sites.
Results:
We performed 1,351 transfusions in 16 months. The transparency of the digital inventory at each site was critical to facilitate qualification, randomization, and overnight shipments of blood group-compatible plasma for transfusions into trial participants. While inventory challenges were heightened with COVID-19 convalescent plasma, the cloud-based system, and the flexible approach of the plasma coordination center staff across the blood bank network enabled decentralized procurement and distribution of investigational products to maintain inventory thresholds and overcome local supply chain restraints at the sites.
Conclusion:
The rapid creation of a plasma coordination center for outpatient transfusions is infrequent in the academic setting. Distributing more than 3,100 plasma units to blood banks charged with managing investigational inventory across the U.S. in a decentralized manner posed operational and regulatory challenges while providing opportunities for the plasma coordination center to contribute to research of global importance. This program can serve as a template in subsequent public health emergencies.
While clinical research intends to improve health outcomes for all, access to research participation is often limited and inequitable. Geographic proximity is a recognized barrier, thus, systemic infrastructure solutions through federal programs including General Clinical Research Centers and Clinical and Translational Science Awards have sought to improve accessibility. Even with such support, academic medical centers often have limited clinical research-dedicated space apart from shared exam rooms in difficult-to-navigate hospitals or clinics. In 2019, the Duke University School of Medicine looked beyond its medical center campus to identify free-standing sites within Durham communities for participant study visits. Catalyzed by the COVID-19 pandemic, Duke Research at Pickett, a 22 000-square-foot building with a laboratory, 30 exam rooms, and on-site parking, opened in October 2020 to support vaccine and treatment trials. Upon the lifting of many COVID-19 restrictions, and in partnership with the Research Equity and Diversity Initiative (READI) Community Advisory Council, the building was transformed to encourage community gatherings, education, and training programs. To date, Duke Research at Pickett has hosted 2692 participants in 78 research trials and 14 community-engaged activities.
Thomas Skidmore and Peter Smith, well-known historians of Latin America, characterized the minimal attention that Central America has received from scholars. From their perspective, neglect of Central America:
is partly due to the relative paucity of archives, libraries, and research centers in the nations of the isthmus. It is partly due to the smallness of the individual countries, which makes them appear less significant than Argentina, Brazil, or Mexico. And it is also due to the common assumption that the countries of Central America are backward: the least developed area in a developing world. Dominated by dictators, the ‘banana republics’ of the isthmus were viewed as sleepy relics of the past. (Skidmore and Smith, 2001, p 316)
Though their comments were directed at the lack of attention from US scholars, this argument is at least (if not more) relevant for scholars from other regions that are even farther removed (geographically, economically, etc.) than North America. And though these comments do not name the countries and colonial territories of the Latin Caribbean, they are no less applicable there. Indeed, as Allahar argues with regard to the Spanish-speaking Caribbean, not only is this region neglected by academics, but this neglect ‘is synonymous with erasure and constitutes a major obstacle for anyone wishing to develop a truly comprehensive understanding of the entire region’ (2005, p 126). As will be further explained later on, the present volume seeks to make a contribution to the scholarship on these regions – Central America and the Latin Caribbean (CALC) – by drawing attention to the global and local forces that influence the relationship between education and development.
First, however, it is important to underscore the fact that, despite relative academic neglect, the region has been, and continues to be, important in numerous ways. In other words, while ‘Central America was [historically] not a source of great wealth’ and while it ‘received correspondingly little attention from the Spanish crown’, its perception as a source of wealth changed in the 19th century, as further explained in Chapter 2 of this volume (Skidmore and Smith, 2001, p 319).
This book has emerged from the long-term engagement of the editors in research on Central America and the Latin Caribbean (CALC). There are other books about education in this region, but they are relatively few in number, and they tend not to address the issues of central concern here – namely, the way that education policy and its enactment is the result of the interaction of global forces, national actors, and local responses. Put differently, research on education in the CALC region has tended to shy away from looking explicitly at the way that education is shaped by larger political-economic forces. And, moreover, the extant scholarship has shied away from taking the additional step of interpreting global-local dynamics in relation to the dialectic of the state and capitalism. What we have in mind here is how education reform is central to resolving tensions that emerge as states and other actors seek to manage threats (for example, relating to the legitimacy of prevailing political and economic systems) that result from states’ embeddedness in the global capitalist economy.
The questions that guide this volume derive from the above observations. The chapter authors examine a variety of education policy themes, ranging from community-based management to decentralization, privatization, digital technologies, gender inequities, gang influence, peer bullying, and sexual violence, among others. In all cases, however, the chapters are concerned with rooting their analysis in a consideration of how the case of interest is influenced by larger political-economic forces. This is then followed, in the cross-case analyses (presented in the final two chapters), by an explicit interest in explaining whether, how, and to what extent the development and implementation of education policy in the CALC region connects with the dialectic between the state and capitalism.
Thus, to restate, in addition to making visible what is often left out of view – that is, the multilevel politics behind education policies – a primary goal of this volume is to make obvious that which is typically unacknowledged or insufficiently addressed in research on education in CALC: the extent to which education, in its reform and implementation (or lack thereof), is inextricably linked to and constrained by tensions and incentives produced as a result of the relationship between the state and the global capitalist economy.
We investigated whether people’s risk taking tendency established in one domain (gains or losses) carries over to the other domain. Participants played a game in which they made repeated decisions between a fixed payoff and a risky option, where the outcome of the risky option depended on whether they had responded correctly on a difficult perceptual-memory task. In some trials, participants played to gain points; on others, they played to avoid losing points. In two studies, we observed the following pattern of results. 1) Participants risked less on gain trials than on loss trials. 2) This difference in risk taking persisted (carried over) when the domain changed from gains to losses and vice versa (with the effect of experiencing losses first being stronger than the effect of experiencing gains first). 3) There was no analogous carryover effect on responses to a delay discounting measure, but there was a carryover effect on responses on a risk attitude measure. We compare these results with those from other recent studies and discuss various ways of explaining them.
The first demonstration of laser action in ruby was made in 1960 by T. H. Maiman of Hughes Research Laboratories, USA. Many laboratories worldwide began the search for lasers using different materials, operating at different wavelengths. In the UK, academia, industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications. This historical review looks at the contribution the UK has made to the advancement of the technology, the development of systems and components and their exploitation over the last 60 years.
The Rapid ASKAP Continuum Survey (RACS) is the first large-area survey to be conducted with the full 36-antenna Australian Square Kilometre Array Pathfinder (ASKAP) telescope. RACS will provide a shallow model of the ASKAP sky that will aid the calibration of future deep ASKAP surveys. RACS will cover the whole sky visible from the ASKAP site in Western Australia and will cover the full ASKAP band of 700–1800 MHz. The RACS images are generally deeper than the existing NRAO VLA Sky Survey and Sydney University Molonglo Sky Survey radio surveys and have better spatial resolution. All RACS survey products will be public, including radio images (with $\sim$ 15 arcsec resolution) and catalogues of about three million source components with spectral index and polarisation information. In this paper, we present a description of the RACS survey and the first data release of 903 images covering the sky south of declination $+41^\circ$ made over a 288-MHz band centred at 887.5 MHz.
Studies suggest that alcohol consumption and alcohol use disorders have distinct genetic backgrounds.
Methods
We examined whether polygenic risk scores (PRS) for consumption and problem subscales of the Alcohol Use Disorders Identification Test (AUDIT-C, AUDIT-P) in the UK Biobank (UKB; N = 121 630) correlate with alcohol outcomes in four independent samples: an ascertained cohort, the Collaborative Study on the Genetics of Alcoholism (COGA; N = 6850), and population-based cohorts: Avon Longitudinal Study of Parents and Children (ALSPAC; N = 5911), Generation Scotland (GS; N = 17 461), and an independent subset of UKB (N = 245 947). Regression models and survival analyses tested whether the PRS were associated with the alcohol-related outcomes.
Results
In COGA, AUDIT-P PRS was associated with alcohol dependence, AUD symptom count, maximum drinks (R2 = 0.47–0.68%, p = 2.0 × 10−8–1.0 × 10−10), and increased likelihood of onset of alcohol dependence (hazard ratio = 1.15, p = 4.7 × 10−8); AUDIT-C PRS was not an independent predictor of any phenotype. In ALSPAC, the AUDIT-C PRS was associated with alcohol dependence (R2 = 0.96%, p = 4.8 × 10−6). In GS, AUDIT-C PRS was a better predictor of weekly alcohol use (R2 = 0.27%, p = 5.5 × 10−11), while AUDIT-P PRS was more associated with problem drinking (R2 = 0.40%, p = 9.0 × 10−7). Lastly, AUDIT-P PRS was associated with ICD-based alcohol-related disorders in the UKB subset (R2 = 0.18%, p < 2.0 × 10−16).
Conclusions
AUDIT-P PRS was associated with a range of alcohol-related phenotypes across population-based and ascertained cohorts, while AUDIT-C PRS showed less utility in the ascertained cohort. We show that AUDIT-P is genetically correlated with both use and misuse and demonstrate the influence of ascertainment schemes on PRS analyses.