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Many snow models have been developed for various applications such as hydrology, global atmospheric circulation models and avalanche forecasting. The degree of complexity of these models is highly variable, ranging from simple index methods to multi-layer models that simulate snow-cover stratigraphy and texture. In the framework of the Snow Model Intercomparison Project (SnowMIP), 23 models were compared using observed meteorological parameters from two mountainous alpine sites. The analysis here focuses on validation of snow energy-budget simulations. Albedo and snow surface temperature observations allow identification of the more realistic simulations and quantification of errors for two components of the energy budget: the net short- and longwave radiation. In particular, the different albedo parameterizations are evaluated for different snowpack states (in winter and spring). Analysis of results during the melting period allows an investigation of the different ways of partitioning the energy fluxes and reveals the complex feedbacks which occur when simulating the snow energy budget. Particular attention is paid to the impact of model complexity on the energy-budget components. The model complexity has a major role for the net longwave radiation calculation, whereas the albedo parameterization is the most significant factor explaining the accuracy of the net shortwave radiation simulation.
The advent of sequencing technologies has revolutionized our understanding and approach to studying biological systems. Indeed, whole-genome sequencing projects have already targeted many different species, enabling the identification of most genes in those organisms. However, observed phenotypes cannot be explained by genes alone, but rather by the interactions that their products establish under some environmental conditions (Waddington 1957). Thus, it is through the analysis of these interaction net-works (e.g. regulatory, metabolic, molecular, or genetic) that we can better understand the genotype-to-phenotype relationship, the complexity and evolution of organisms, or the differences among individuals of the same species. The topology and dynamics of these biological networks can be unveiled by systematic perturbation of their nodes (i.e. genes). For instance, upon single-gene deletions in Saccharomyces cerevisiae under standard laboratory conditions, most genes (∼80%) were not found to be essential for cell viability (Giaever et al. 2002). Though many of these genes may be required for growth in other environments (Hillenmeyer et al. 2008), this result suggests extensive functional redundancy among genes. Such functional buffering confers robustness to biological networks and shields the cellular machinery from genetic perturbations (Hartman et al. 2001). Additionally, the small effect on phenotype that many gene deletions exhibit (see Figure 2.1) evidences that single perturbations alone cannot capture the complexity of the genotype-to-phenotype relationship. Therefore, a combinatorial approach to gene perturbations is best suited to elucidate biological systems and can enable a better characterization of genes and cellular functioning.
Definition of genetic interaction
Genetic interactions reveal functional relations between genes that contribute to a pheno-typic trait. William Bateson first introduced the term, formerly known as epistasis (see Phillips [1998] for a description on the origin and evolution of the definition), to refer to an allele at one locus preventing a variant at another from manifesting its effect (Bateson 1909).
We report the intermixing enhancement using the Ge-doped sol-gel derived silica encapsulant layer in InGaAs/InGaAsP quantum-well laser structure. A bandgap shift of ∼64 nm has been observed from 16% Ge-doped silica capped sample at an annealing temperature of 630°C while the intermixing at the similar temperature can be effectively suppressed with the e-beam evaporated SiO2 encapsulant layer. Using our theoretical model, nearly identical activation energy of 1.7±0.5 eV was obtained from the intermixed sample with Ge-doped silica. Similar intermixing enhancement holds for high Ge-content cap in the intermixed GaAs/AlGaAs quantum-wells related to Ga vacancy injection. We postulate that the dissimilarity in interdiffusion behavior between 0% and 16% Ge-doped silica capped sample is only attributed to the difference in the number of beneficial vacancies that involve in the intermixing process.
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