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Recent changes to US research funding are having far-reaching consequences that imperil the integrity of science and the provision of care to vulnerable populations. Resisting these changes, the BJPsych Portfolio reaffirms its commitment to publishing mental science and advancing psychiatric knowledge that improves the mental health of one and all.
The effects of rainfall and temperature on the seasonal phenology of ant nuptial flights in a forest locality in Ghana was studied for 42 months using a light-trap. A total of 204393 ants was caught. Of the 135 species/morphospecies collected, 40 could not be identified beyond genus, and males of a further 14 beyond subfamily. The commonest 65 species/morphospecies flew a mean of 10.1 ± 0.4 months per year. With the exception of males of Dorylus atriceps, Platythyrea conradti, Plat. modesta, Crematogaster nr striatula plus gynes of Plagiolepis brunni and Cr. [F257], whose peak flights occurred in the main dry season, flight activity coincided with the onset of the rainy seasons. Both sexes of Pheidole megacephala, P. speculifera, Tetramorium aculeatum, and Paraparatrechina albipes plus gynes of Cr. striatula and males of Anochetus africanus, Hypoponera dulcis, Cr. kneri, and T. guineensis flew more frequently on rainy than dry dates. Nineteen species were caught more frequently on dry than on wet dates including most Camponotus, Tapinoma, and Technomyrmex spp. Fifteen species/morphospecies responded positively to increasing monthly rainfall, six to increasing monthly temperatures, and five to the interaction between these factors, with males of A. pellucidus, H. dulcis, and Cr. striatula caught more frequently in wetter, warmer months, and those of Camponotus olivieri and Technomyrmex andrei in drier, warmer ones.
Pursuant to s 5(1) of the Disability Discrimination Act 1992 (Cth) (“the Act“), an alleged discriminator will have discriminated against a person with a disability if they treat the disabled person less favourably, because of their disability, than they treat or would have treated someone without the disability, ‘in circumstances that are the same or are not materially different'.
A matter crucial to the assessment of whether there has been illegal discrimination for the purposes of the Act, therefore, is what constitutes the circumstances of the aggrieved person's case. In order for there to be a contravention of the Act not only must the alleged discriminator have treated the disabled person less favourably than they would have treated someone without a disability, but the alleged discriminator must have treated the disabled person less favourably than they would have treated someone without a disability who was in the same circumstances as the person with the disability.
Traditionally, statutory provisions prohibiting direct discrimination have employed a test of less favourable treatment. This test is controversial since it requires the use of a comparator, which is widely regarded as giving rise to a range of serious problems. It is commonly assumed, both by academics and legislators, that reliance on a comparator, and the problems to which such reliance gives rise, can be avoided by employing a test of unfavourable treatment instead of a test of less favourable treatment. In this article, we subject this assumption to critical scrutiny. We acknowledge that, on what is probably the most common understanding of the test of unfavourable treatment, employing that test does avoid the need to rely on a comparator. However, we argue that this understanding renders the test of unfavourable treatment radically over-inclusive. We then consider alternative approaches to understanding the test of unfavourable treatment, and investigate whether these approaches avoid the need to rely on a comparator whilst also avoiding the over-inclusiveness problem. We argue that this depends, ultimately, on what the value is that underlies prohibitions on discrimination.
Globally, there is seasonal variation in tuberculosis (TB) incidence, yet the biological and behavioural or social factors driving TB seasonality differ across countries. Understanding season-specific risk factors that may be specific to the UK could help shape future decision-making for TB control. We conducted a time-series analysis using data from 152,424 UK TB notifications between 2000 and 2018. Notifications were aggregated by year, month, and socio-demographic covariates, and negative binomial regression models fitted to the aggregate data. For each covariate, we calculated the size of the seasonal effect as the incidence risk ratio (IRR) for the peak versus the trough months within the year and the timing of the peak, whilst accounting for the overall trend. There was strong evidence for seasonality (p < 0.0001) with an IRR of 1.27 (95% CI 1.23–1.30). The peak was estimated to occur at the beginning of May. Significant differences in seasonal amplitude were identified across age groups, ethnicity, site of disease, latitude and, for those born abroad, time since entry to the UK. The smaller amplitude in older adults, and greater amplitude among South Asians and people who recently entered the UK may indicate the role of latent TB reactivation and vitamin D deficiency in driving seasonality.
Parents’ discrimination against their children is lawful. But the family, as an institution in which social goods are allocated, is as significant as the sites in which anti-discrimination law operates. At least prima facie, therefore, parents should be governed by legal prohibitions on discrimination. While state incursion into family life poses a threat to children’s autonomy, so does parental discrimination against children. Anti-discrimination law therefore needs new institutions to promote the values of non-discrimination in a part of society that currently sits outside anti-discrimination law’s reach. We identify existing regimes that may provide a starting point for this work.
Interacting biological systems at all organizational levels display emergent behavior. Modeling these systems is made challenging by the number and variety of biological components and interactions – from molecules in gene regulatory networks to species in ecological networks – and the often-incomplete state of system knowledge, such as the unknown values of kinetic parameters for biochemical reactions. Boolean networks have emerged as a powerful tool for modeling these systems. This Element provides a methodological overview of Boolean network models of biological systems. After a brief introduction, the authors describe the process of building, analyzing, and validating a Boolean model. They then present the use of the model to make predictions about the system's response to perturbations and about how to control its behavior. The Element emphasizes the interplay between structural and dynamical properties of Boolean networks and illustrates them in three case studies from disparate levels of biological organization.
We examine the predictability of stock returns using implied volatility spreads (VS) from individual (nonindex) options. VS can occur under simple no-arbitrage conditions for American options when volatility is time-varying, suggesting that the VS-return predictability could be an artifact of firms’ sensitivities to aggregate volatility. Examining this empirically, we find that the predictability changes systematically with aggregate volatility and is positively related to the firms’ sensitivities to volatility risk. The alpha generated by VS hedge portfolios can be explained by aggregate volatility risk factors. Our results cannot be explained by firm-specific informed trading, transaction costs, or liquidity.
Our objective was to compare patterns of dental antibiotic prescribing in Australia, England, and North America (United States and British Columbia, Canada).
Design:
Population-level analysis of antibiotic prescription.
Setting:
Outpatient prescribing by dentists in 2017.
Participants:
Patients receiving an antibiotic dispensed by an outpatient pharmacy.
Methods:
Prescription-based rates adjusted by population were compared overall and by antibiotic class. Contingency tables assessed differences in the proportion of antibiotic class by country.
Results:
In 2017, dentists in the United States had the highest antibiotic prescribing rate per 1,000 population and Australia had the lowest rate. The penicillin class, particularly amoxicillin, was the most frequently prescribed for all countries. The second most common agents prescribed were clindamycin in the United States and British Columbia (Canada) and metronidazole in Australia and England. Broad-spectrum agents, amoxicillin-clavulanic acid, and azithromycin were the highest in Australia and the United States, respectively.
Conclusion:
Extreme differences exist in antibiotics prescribed by dentists in Australia, England, the United States, and British Columbia. The United States had twice the antibiotic prescription rate of Australia and the most frequently prescribed antibiotic in the US was clindamycin. Significant opportunities exist for the global dental community to update their prescribing behavior relating to second-line agents for penicillin allergic patients and to contribute to international efforts addressing antibiotic resistance. Patient safety improvements will result from optimizing dental antibiotic prescribing, especially for antibiotics associated with resistance (broad-spectrum agents) or C. difficile (clindamycin). Dental antibiotic stewardship programs are urgently needed worldwide.
Andrew Harding, in his excursus on ‘legal transplantation’, observed: ‘[W]e do live in a world of legal connectivity in which we share common problems which can only be addressed by a limited range of solutions which are unlikely not to have been tried before’. This prescient remark is apt in the context of the growing importance of the proportionality concept in the Australian public law arena. The proportionality concept attained particular prominence when the High Court of Australia found a freedom of political communication impliedly embedded in the Constitution. It was inevitable that with the establishment of such an implied fundamental constitutional guarantee, the High Court had to craft a principle to enable the saving or invalidation of legislation claimed to be in violation of the implied freedom.
This chapter examines the extent to which there is, or may be, accountability with regard to the exercise of such powers as a result of the administrative mechanism of judicial review. It examines the way in which judges, in exercising restraint, may hinder the bringing of successful review applications with regard to exercises of emergency powers. It also focuses on express attempts by the legislature to limit the availability of judicial review, in the form of privative clauses, and the possible impact of those attempts on the review of emergency powers. Doctrines relating to ‘justiciability’, ‘act of state, ‘deference’, and procedural fairness are highlighted.
This chapter examines the power of Australian governments, both federal and state, to address public disorder against a backdrop of recognised constitutional protections for political assembly, especially the judicially established implied freedom of political communication. The laws, statutory and common law, pertaining to unlawful assembly, anti-association legislative measures, sedition, and special public disorder emergency powers are scrutinised.
The chapter focuses on the constitutional and legal frameworks regulating the call-out of the Australian Defence Force in aid of the civil power. This topic has become more prominent as result of the rise of global terrorism. It examines the implications of the Lindt Café siege and the 1978 Sydney Hilton bombing. The constitutional provisions of section 119 are scrutinised to determine the framework under which the military forces are deployed to assist a state against domestic violence. The Defence Act 1903 (Cth) is discussed.
This chapter describes the sorts of emergencies which have been experienced in Australia, including the contemporary war on terrorism.It explores the definitional problems of 'emergency', the dangers of over-reaction to an emergency as exemplified by the experience in some countries. It makes reference to international norms regulating the exercise of emergency powers.
This chapter examines the panoply of special powers frameworks for dealing with civil emergencies, particularly environmental emergencies, chemical, biological, radiological and nuclear emergencies, and public and biosecurity emergencies. It also looks at ad-hoc legislation conferring special powers in respone to a particular situation of emergency.