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175 results

Page 1 of 9

  • N95® filtering facepiece respirator contamination with SARS-CoV-2 following reuse and extended use

  • James S. Ford, Ralph C. Wang, Benjamin Stephenson, Nida F. Degesys, Jahan Fahimi, Edward M. Fisher, Delbert Harnish, Courtney M.C. Jones, Susan Peterson, Efrat Rosenthal, Richard Rothmann, Manish N. Shah, Vaishal Tolia, Anna Q. Yaffee, Katherine N. Yoon, Maria C. Raven, for the ReuseN95 Group
  • Journal:
    Infection Control & Hospital Epidemiology , First View
    Published online by Cambridge University Press:
    14 July 2025, pp. 1-6
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  • Objective:

    During the COVID-19 pandemic, the United States Centers for Disease Control and Prevention provided strategies, such as extended use and reuse, to preserve N95 filtering facepiece respirators (FFR). We aimed to assess the prevalence of N95 FFR contamination with SARS-CoV-2 among healthcare personnel (HCP) in the Emergency Department (ED).

    Design:

    Real-world, prospective, multicenter cohort study. N95 FFR contamination (primary outcome) was measured by real-time quantitative polymerase chain reaction. Multiple logistic regression was used to assess factors associated with contamination.

    Setting:

    Six academic medical centers.

    Participants:

    ED HCP who practiced N95 FFR reuse and extended use during the COVID-19 pandemic between April 2021 and July 2022.

    Primary exposure:

    Total number of COVID-19-positive patients treated.

    Results:

    Two-hundred forty-five N95 FFRs were tested. Forty-four N95 FFRs (18.0%, 95% CI 13.4, 23.3) were contaminated with SARS-CoV-2 RNA. The number of patients seen with COVID-19 was associated with N95 FFR contamination (adjusted odds ratio, 2.3 [95% CI 1.5, 3.6]). Wearing either surgical masks or face shields over FFRs was not associated with FFR contamination, and FFR contamination prevalence was high when using these adjuncts [face shields: 25% (16/64), surgical masks: 22% (23/107)].

    Conclusions:

    Exposure to patients with known COVID-19 was independently associated with N95 FFR contamination. Face shields and overlying surgical masks were not associated with N95 FFR contamination. N95 FFR reuse and extended use should be avoided due to the increased risk of contact exposure from contaminated FFRs.

  • Adult otitis media with effusion, non-tuberculous mycobacteria and olfactometry

  • Edward Fisher
  • Journal:
    The Journal of Laryngology & Otology / Volume 139 / Issue 5 / May 2025
    Published online by Cambridge University Press:
    30 June 2025, pp. 337-338
    Print publication:
    May 2025
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  • JLO ‘Best paper’ prizes 2024

  • Jonathan Fishman, Edward W Fisher
  • Journal:
    The Journal of Laryngology & Otology / Volume 139 / Issue 3 / March 2025
    Published online by Cambridge University Press:
    20 May 2025, pp. 151-152
    Print publication:
    March 2025
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  • A new MIS 5 to MIS 2 speleothem record from Sandkraal Cave on the South African Cape south coast

  • Kerstin Braun, Miryam Bar-Matthews, Avner Ayalon, Alan Matthews, Tami Zilberman, Natalya Zolotova, Richard M. Cowling, Panagiotis Karkanas, Hayley C. Cawthra, Erich C. Fisher, R. Lawrence Edwards, Xianglei Li, Curtis W. Marean
  • Journal:
    Quaternary Research / Volume 118 / March 2024
    Published online by Cambridge University Press:
    12 March 2024, pp. 142-161
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  • We present new stable oxygen and carbon isotope composite records (δ18O, δ13C) of speleothems from Sandkraal Cave 1 (SK1) on the South African south coast for the time interval between 104 and 18 ka (with a hiatus between 48 and 41 ka). Statistical comparisons using kernel-based correlation analyses and semblance analyses based on continuous wavelet transforms inform the relationships of the new speleothem records to other proxies and their changes through time. Between 105 and ~70 ka, changes of speleothem δ18O values at SK1 are likely related to rainfall seasonality. Variations of δ13C values are associated with changes of vegetation density, prior carbonate precipitation (PCP), CO2 degassing in the cave, and possibly variations of the abundance of C3 and C4 grasses in the vegetation. The relationships of δ18O with other proxies shift between ~70 and 48 ka (Marine Isotope Stages 4–3) so that both stable isotope records now reflect CO2 degassing, evaporation, and PCP. Similar relationships also continue after the hiatus for the deposition phase between 42 and 18 ka. Our findings support modeling results suggesting drier conditions in the study area when the Southern Hemisphere westerlies are shifted north and the paleo–Agulhas Plain is exposed.

Page 1 of 9