We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
We report the discovery of a bow-shock pulsar wind nebula (PWN), named Potoroo, and the detection of a young pulsar J1638$-$4713 that powers the nebula. We present a radio continuum study of the PWN based on 20-cm observations obtained from the Australian Square Kilometre Array Pathfinder (ASKAP) and MeerKAT. PSR J1638$-$4713 was identified using Parkes radio telescope observations at frequencies above 3 GHz. The pulsar has the second-highest dispersion measure of all known radio pulsars (1 553 pc cm$^{-3}$), a spin period of 65.74 ms and a spin-down luminosity of $\dot{E}=6.1\times10^{36}$ erg s$^{-1}$. The PWN has a cometary morphology and one of the greatest projected lengths among all the observed pulsar radio tails, measuring over 21 pc for an assumed distance of 10 kpc. The remarkably long tail and atypically steep radio spectral index are attributed to the interplay of a supernova reverse shock and the PWN. The originating supernova remnant is not known so far. We estimated the pulsar kick velocity to be in the range of 1 000–2 000 km s$^{-1}$ for ages between 23 and 10 kyr. The X-ray counterpart found in Chandra data, CXOU J163802.6$-$471358, shows the same tail morphology as the radio source but is shorter by a factor of 10. The peak of the X-ray emission is offset from the peak of the radio total intensity (Stokes $\rm I$) emission by approximately 4.7$^{\prime\prime}$, but coincides well with circularly polarised (Stokes $\rm V$) emission. No infrared counterpart was found.
Two hundred and ten pigs were reared in three groups (according to genotype) under enriched conditions of large open-front sawdust-bedded barns. Eight hundred and twenty pigs were reared under standard conditions of small 15-animal pens in a conventional barn with partially slatted floors and natural ventilation. Production parameters including percentage mortality, feed conversion rate and average daily weight gain were calculated at the end of the fattening period. Stomachs, limbs and lungs were examined at slaughter in order to compare the number and severity of lesions between the enriched environment groups and the standard environment group. There was a significantly greater number of esophagogastric lesions in the standard environment group than in the enriched environment groups. No esophagogastric ulcers were observed in any pigs from the enriched groups, while 17.5% of stomachs from pigs in the standard environment group displayed this condition. There were no significant differences in the number of lung lesions associated with enzootic pneumonia between pigs from the standard and enriched environment groups. The limbs of animals reared in the standard environment had more lesions, especially in floor-contact areas, than those reared in the enriched environment (23.84% versus 1.08%). The production parameters measured were improved in the pigs from the enriched environment. These results suggest that the welfare of fattening pigs may be improved by the provision of enrichment in their housing environment. Evaluation of esophagogastric ulceration could be a useful indicator of welfare in pigs.
We have found a class of circular radio objects in the Evolutionary Map of the Universe Pilot Survey, using the Australian Square Kilometre Array Pathfinder telescope. The objects appear in radio images as circular edge-brightened discs, about one arcmin diameter, that are unlike other objects previously reported in the literature. We explore several possible mechanisms that might cause these objects, but none seems to be a compelling explanation.
To assess the safety of, and subsequent allergy documentation associated with, an antimicrobial stewardship intervention consisting of test-dose challenge procedures prompted by an electronic guideline for hospitalized patients with reported β-lactam allergies.
Design:
Retrospective cohort study.
Setting:
Large healthcare system consisting of 2 academic and 3 community acute-care hospitals between April 2016 and December 2017.
Methods:
We evaluated β-lactam antibiotic test-dose outcomes, including adverse drug reactions (ADRs), hypersensitivity reactions (HSRs), and electronic health record (EHR) allergy record updates. HSR predictors were examined using a multivariable logistic regression model. Modification of the EHR allergy record after test doses considered relevant allergy entries added, deleted, and/or specified.
Results:
We identified 1,046 test-doses: 809 (77%) to cephalosporins, 148 (14%) to penicillins, and 89 (9%) to carbapenems. Overall, 78 patients (7.5%; 95% confidence interval [CI], 5.9%–9.2%) had signs or symptoms of an ADR, and 40 (3.8%; 95% CI, 2.8%–5.2%) had confirmed HSRs. Most HSRs occurred at the second (ie, full-dose) step (68%) and required no treatment beyond drug discontinuation (58%); 3 HSR patients were treated with intramuscular epinephrine. Reported cephalosporin allergy history was associated with an increased odds of HSR (odds ratio [OR], 2.96; 95% CI, 1.34–6.58). Allergies were updated for 474 patients (45%), with records specified (82%), deleted (16%), and added (8%).
Conclusion:
This antimicrobial stewardship intervention using β-lactam test-dose procedures was safe. Overall, 3.8% of patients with β-lactam allergy histories had an HSR; cephalosporin allergy histories conferred a 3-fold increased risk. Encouraging EHR documentation might improve this safe, effective, and practical acute-care antibiotic stewardship tool.
The neuropeptides oxytocin (OT) and arginine vasopressin (AVP) play important and interrelated roles in modulating mammalian social behaviour. While the OT system has received considerable research attention for its potential to treat psychiatric symptoms, comparatively little is known about the role of the AVP system in human social behaviour. To better understand the intraindividual stability of basal AVP, the present study assessed the reproducibility of basal plasma AVP concentrations.
Methods
Basal plasma AVP was assessed at four sampling points separated by 8 days, on average, in 16 healthy adult males.
Results
Only one out of six comparisons revealed strong evidence for reproducibility of basal AVP concentrations (visit 2 vs. visit 4: r=0.8, p<0.001; all other comparisons p>0.1). The concordance correlation coefficient [0.15, 95% CI (−0.55, 0.73)] also revealed poor overall reproducibility.
Conclusion
Poor reliability of basal AVP concentrations suggests future work covarying AVP with trait markers should proceed with careful consideration of intraindividual fluctuations.
We consider the symmetry of cylindrical implosions of laser targets with parameters corresponding to experiments proposed for the LIL laser facility at Bordeaux: eight laser beams in octahedrical configuration, delivering a total of 50 kJ of 0.35 µm laser light in 5 ns, impinging on 1.26 mm diameter polystyrene cylindrical shells filled with deuterium at 30 bar and 5.35 mg cm−3; this configuration allows to place diagnostics along the symmetry axis to evaluate directly the uniformity of implosion. Numerical studies have been carried out by using the hydrodynamic computer codes MULTI and CHIC, including one-dimensional, and two-dimensional R–Z and R–θ simulations. Deuterium is compressed into a 1 mm long and 50 µm diameter filament, with density ranging from 2 to 6 g cm−3 and temperatures above 1000 eV. In spite of the reduced numbers of beams, a good symmetry can be achieved with a careful choice of the irradiation pattern. The heat transport smoothing between laser absorption zone and ablation layer plays a fundamental role in the attenuation of residual non-uniformities. Also, it has been found that the radiation transport determines the radial structure of the compressed filament.
Anthony Shadid is a talented correspondent for Boston's Globe who is now based in Washington, D.C. and who has covered the Middle East with distinction in recent years. As I discovered during the past year while I lived in Boston, his articles routinely provide important insights into the politics and people of the Arab world, routinely capturing the human complexities of issues that other correspondents often miss.
The efficacy of a field vacuum unit for the management of Bemisia tabaci was evaluated on melon (Cucumis melo L.) during two summer seasons. The tractor-mounted unit was designed to dislodge insects by blowing air from lateral vents onto the plants while simultaneously vacuuming from above. Field observations, collection of leaf samples, and hand-vacuum sampling before and after the field vacuuming were used to evaluate the efficacy of removal. Bemisia tabaci population reductions were significant (30–60%) and lasted from week to week when vacuumed weekly. Parasitoid populations were slightly affected, but were not significantly different from populations in the untreated control plot. Field vacuuming was found to be as effective as insecticide applications for the control of B. tabaci in melons.
Recommend this
Email your librarian or administrator to recommend adding this to your organisation's collection.