We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Pablo Neruda in Context includes forty-two essays by some of the main experts on Pablo Neruda's oeuvre that focus on how his places of residence and travel (Mexico, Argentina, Spain, France, Asia), the landmark event of the Cold War, as well as literary and political influences affected his poetic evolution. It also considers the other genres of his writing, including memoirs, letters, translation, and drama, as well as the musical and film adaptions of his work throughout the world. Other essays study his anti-colonial and ecocritical messages, his complicated relationships with women and other writers, as well as his take on race and the significance of his plausible assassination by Augusto Pinochet's military junta. The last section explores Neruda's poetry as world literature as well as his impressive reception in India, Japan, China, the Arab world, the Anglophone world, Russia and Eastern Europe, and his overall lasting legacy.
Static analysis is an essential component of many modern software development tools. Unfortunately, the ever-increasing complexity of static analyzers makes their coding error-prone. Even analysis tools based on rigorous mathematical techniques, such as abstract interpretation, are not immune to bugs. Ensuring the correctness and reliability of software analyzers is critical if they are to be inserted in production compilers and development environments. While compiler validation has seen notable success, formal validation of static analysis tools remains relatively unexplored. In this paper we present checkification, a simple, automatic method for testing static analyzers. Broadly, it consists in checking, over a suite of benchmarks, that the properties inferred statically are satisfied dynamically. The main advantage of our approach lies in its simplicity, which stems directly from framing it within the Ciao assertion-based validation framework, and its blended static/dynamic assertion checking approach. We demonstrate that in this setting, the analysis can be tested with little effort by combining the following components already present in the framework: 1) the static analyzer, which outputs its results as the original program source with assertions interspersed; 2) the assertion run-time checking mechanism, which instruments a program to ensure that no assertion is violated at run time; 3) the random test case generator, which generates random test cases satisfying the properties present in assertion preconditions; and 4) the unit-test framework, which executes those test cases. We have applied our approach to the CiaoPP static analyzer, resulting in the identification of many bugs with reasonable overhead. Most of these bugs have been either fixed or confirmed, helping us detect a range of errors not only related to analysis soundness but also within other aspects of the framework.
Updated estimates of 2024 ice thickness, the surface elevation losses in the last years and simulations of mass balance and evolution (using the Instructed Glacier Model) for the three largest Pyrenean glaciers strongly suggest that by 2034 the Pyrenees will be ice-free. If extreme summers like 2022 and 2023 recur, this could happen even earlier. We show that by 2030, 94% (from 0.22 to 0.01 km2) of the ice in Monte Perdido, 91% (from 0.22 to 0.05 km2) of the ice in Ossoue and 79% of the ice in Aneto (from 0.34 to 0.06 km2) will have melted under the RCP4.5 scenario; these numbers are 83%, 72% and 57% under a committed ice loss scenario, meaning that only 0.05, 0.12 and 0.12 km2 of ice will remain, respectively. In 2034, most likely they will have completely disappeared under the three considered scenarios (RCP 4.5, ‘committed ice loss’ and extreme 2022 year in a loop). The loss of these glaciers is a harbinger for what will happen in many other mountain regions.
Studies conducted during the COVID-19 pandemic found high occurrence of suicidal thoughts and behaviours (STBs) among healthcare workers (HCWs). The current study aimed to (1) develop a machine learning-based prediction model for future STBs using data from a large prospective cohort of Spanish HCWs and (2) identify the most important variables in terms of contribution to the model’s predictive accuracy.
Methods
This is a prospective, multicentre cohort study of Spanish HCWs active during the COVID-19 pandemic. A total of 8,996 HCWs participated in the web-based baseline survey (May–July 2020) and 4,809 in the 4-month follow-up survey. A total of 219 predictor variables were derived from the baseline survey. The outcome variable was any STB at the 4-month follow-up. Variable selection was done using an L1 regularized linear Support Vector Classifier (SVC). A random forest model with 5-fold cross-validation was developed, in which the Synthetic Minority Oversampling Technique (SMOTE) and undersampling of the majority class balancing techniques were tested. The model was evaluated by the area under the Receiver Operating Characteristic (AUROC) curve and the area under the precision–recall curve. Shapley’s additive explanatory values (SHAP values) were used to evaluate the overall contribution of each variable to the prediction of future STBs. Results were obtained separately by gender.
Results
The prevalence of STBs in HCWs at the 4-month follow-up was 7.9% (women = 7.8%, men = 8.2%). Thirty-four variables were selected by the L1 regularized linear SVC. The best results were obtained without data balancing techniques: AUROC = 0.87 (0.86 for women and 0.87 for men) and area under the precision–recall curve = 0.50 (0.55 for women and 0.45 for men). Based on SHAP values, the most important baseline predictors for any STB at the 4-month follow-up were the presence of passive suicidal ideation, the number of days in the past 30 days with passive or active suicidal ideation, the number of days in the past 30 days with binge eating episodes, the number of panic attacks (women only) and the frequency of intrusive thoughts (men only).
Conclusions
Machine learning-based prediction models for STBs in HCWs during the COVID-19 pandemic trained on web-based survey data present high discrimination and classification capacity. Future clinical implementations of this model could enable the early detection of HCWs at the highest risk for developing adverse mental health outcomes.
Presentamos avances en la exploración del abrigo rocoso Las Columnas situado en la Depresión Central de Chiapas, México. Un fechamiento obtenido por espectrometría de masas con aceleradores (AMS) muestra indicios de actividades humanas entre el 790 aC y 517 aC, período que corresponde con el desarrollo de sistemas políticos complejos mesoamericanos. Las excavaciones arrojaron también restos de talla, alisadores de piedra, caracoles, semillas y cerámica que indican actividades humanas recurrentes. Una muestra de artefactos líticos se analizó con microscopía para determinar su función. Los resultados preliminares indican que el abrigo Las Columnas fue utilizado para actividades domésticas y el procesamiento de huesos y pieles durante el Preclásico medio.
The RedETS horizon scanning (HS) program in Spain is focused on identifying non-pharmaceutical emerging health technologies. HS is organized in three steps: (i) identification using different sources (PubMed, the biomedical press, and others); (ii) screening performed by the HS Working Group and clinicians; and (iii) prioritization using the PriTec tool. This study aimed to evaluate the accuracy of RedETS HS in identifying disruptive emerging technologies for our health system.
Methods
Data from brief files and full reports related to the identified emerging technologies were collected. Full health technology assessment (HTA) reports were also reviewed. The period of analysis was from 2016 to 2023. The information collected included the name, type, category, and indication of the emerging technology and the source of identification. An ad hoc Excel spreadsheet was designed to collect the information. The analysis consisted of a description of the variables and an assessment of concordance between the emerging technologies identified and those with full HTA reports.
Results
There were 338 emerging technologies identified. These technologies were mainly therapeutic (52.1%) or diagnostic (25.7%). In addition, about 45 percent were medical devices and 15.7 percent were in vitro diagnostic tests; imaging comprised 7.4 percent. Most of the emerging technologies were identified through the biomedical press (22.2%), PubMed (23.6%) and industry (20.3%). In a preliminary analysis of these main sources, 31 percent of the technologies identified by HS had full HTA reports, with all of these being identified three years before the HTA.
Conclusions
HS systems might help identify the most relevant technologies for healthcare systems, enabling them to be more ready to incorporate the new technologies. Therefore, HS must be able to detect emerging technologies that will have an impact on the health system. Periodic evaluation of the accuracy of HS programs will improve their impact in the HTA process.
Since its introduction in Spain in 2004, Aedes albopictus has rapidly spread across the country. Its aggressive biting behaviour causes nuisance, limiting outdoor activities. Also, its role as a vector of several arboviruses implies a major public health risk, with several cases of autochthonous dengue having been reported nationwide over the past few years. Control strategies usually focus on interventions in breeding sites. As such, accurate knowledge of the main larval habitats becomes a major priority in infested areas. A detailed identification of breeding sites of Ae. albopictus was carried out in the outdoors of 60 residential properties during July–August 2022 in El Vedat de Torrent (Valencia, Eastern Spain), an area recently colonised by this species. A total of 1444 real and potential breeding sites were examined. The most abundant potential larval habitat were plant pot plates (6.48 units/house), although a low infestation level was found, both for larvae (2.06% positivity, x̄ = 30.5 larvae/container), and pupae (0.51%, x̄ = 2.5 pupae/container). A total of 7715 larvae and 205 pupae were found in a disused flooded water pool depuration system. Animal drinkers, buckets and irrigation water containers were found to be the most common positive containers. No statistical difference was observed among the different container materials. A general statistical increase of 1 larva per 11.7 ml of water in breeding sites was detected. Breeding sites of other species such as Culex pipiens (n = 2) and Culex modestus (n = 1) were also rarely found in this residential area. To our knowledge, this is the first aedic index study carried out in Europe, and it provides valuable information about the main domestic breeding habitats of Ae. albopictus, which can greatly improve control programmes.
Casa Roshell. Dir. Camila José Donoso. Prod. Garbiñe Ortega, Juan Pablo Bastarrachea, Maximiliano Cruz y Sandra Gómez. Chile, 2017, 71 min. https://ondamedia.cl/show/casa-roshell.
El gran circo pobre de Timoteo. Dir. Lorena Giachino Torréns. Prod. Paola Castillo y Marcela Morilla. Chile, 2013, 76 min. https://vimeo.com/ondemand/timoteo.
On 4 June 1943, a military coup crushed Argentina's democracy, marking the end of the oligarchic era and ‘planting the seeds’ of Peronism. This case sheds light on how rulers’ mistakes can operate as a key independent variable in producing regime changes. We argue that the former conservative president, Ramón S. Castillo, provoked an otherwise avoidable democratic breakdown. Specifically, Castillo's misguided relationships with regime insiders and outsiders unintentionally eroded political stability and triggered the fall of democracy. Until now, agent-based scholarship has fallen short in tracing incumbents’ mistakes and linking them to regime-change processes. We test the argument by conducting a within-case analysis of Argentina's democratic fall in the early 1940s, scrutinising the president's errors at five critical events. We conclude that critical-event analysis can help disentangle the role of leaders’ mistakes in other episodes of regime change.
Every American is a descendant of either a Native American, and enslaved person, an immigrant, or a refugee. This book is devoted to the fourth category. The essays in this volume will study the concept of refuge as well as historical forced displacement and statelessness, trying to provide potential lasting solutions to the many problems associated with this situation. This volume is not only timely but expansive, as it moves from the pressing crisis of refugees to the crisis of humanity that seeks to find refuge.
From refugees to asylum seekers, from climate change to war, from historical uprootedness and displacement to today's crisis of refugeeism, these topics are mobilizing humanities scholars to think about refugees with a new sense of urgency. This book demonstrates how interdisciplinary cultural approaches grounded in the humanities can transform refugee conversations so often dominated by political science, economics, and other disciplines. In doing so, the collection sets up far more inclusive refugee discussions and urges humanities thinkers to respond by taking the lead in the face of environmental and sociopolitical uncertainties.
This study explores the evolution of individual attitudes toward homosexuality in Chile during the period 1998–2018. Based on microdata from the International Social Survey Programme, it finds evidence of a significant rise in the share of people accepting homosexual relationships, from 5.4 percent to 38.5 percent of the population. Observable individual-level socioeconomic characteristics are responsible for only 3.6 percentage points of this shift. In particular, the increase in educational attainment and generational replacement help to explain this trend and account for an increase of 2.6 percentage points (roughly 45 percent of the initial level of acceptance). Nevertheless, the bulk of this shift is due to structural changes in Chilean society, which may have increased acceptance across all the demographic subgroups considered in the analysis.
Regarding the low number of embryos that reach the blastocyst stage when cultured in vitro, this study aimed to evaluate the effects of quercetin on pre-implantation mouse (Mus musculus) embryos obtained using in vitro fertilization, especially during the passage from morula to blastocyst. Furthermore, we studied whether quercetin also affected the expression of hypoxia-inducible factor 1α (HIF-1α). The culture medium for the embryos was supplemented with quercetin, for long or short periods of time, and then the development potential, total cell number, apoptosis rates and expression of HIF-1α were studied to determine the effect of quercetin. Embryos failed to develop when cultured for long periods of time with quercetin, implying the possible toxic effects of this, alternatively antioxidant, compound. However, a short culture from morula to blastocyst significantly improved the development potential of in vitro produced embryos, increasing the final total cell number and reducing the apoptosis rate, observing similar results to those embryos cultured in low-oxygen concentrations or developed in utero. Furthermore, in embryos treated with quercetin for 2 or 4 h we found an increase in HIF-1α compared with untreated embryos. This work could imply a way to use quercetin in fertility clinics to improve the production of healthy blastocysts and, consequently, increase the success rates in assisted reproduction techniques.
The significance of love and friendship in Bolaño’s life and oeuvre cannot overstated. Many of his best friends were writers or editors, including Roberto Brodsky, Javier Cercas, Jorge Herralde, Ignacio Padilla, Antoni García “A. G.” Porta, and Juan Villoro. That love and friendship were among Bolaño’s central concerns is unmistakably reflected in his oeuvre. For instance, one of the ways the central character Carlos Weider is demonized in Distant Star is precisely by exposing his betrayal of people who were supposed to be his friends, such as the Garmendia sisters. Friendship is often a key topic, if not the main one, in many of his plots, at times the engine that moves the action. In fact, several of his novels could be considered novels about friendship, including The Savage Detectives and parts of 2666. Many of his drifting characters, in Consejos de un discípulo de Morrison a un fanático de Joyce, Monsieur Pain, Nazi Literature in the Americas,Distant Star, Amulet, By Night in Chile, Antwerp, The Third Reich, Woes of the True Policeman, and The Spirit of Science Fiction, along with several short stories, have long lost hope in utopian political projects and find solace only in true friendships.