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White kidney bean extract (WKBE) is a nutraceutical often advocated as an anti-obesity agent. The main proposed mechanism for these effects is alpha-amylase inhibition, thereby slowing carbohydrate digestion and absorption. Thus, it is possible that WKBE could impact the gut microbiota and modulate gut health. We investigated the effects of supplementing 20 healthy adults with WKBE for 1 week in a randomised, placebo-controlled crossover trial on the composition of the gut microbiota, gastrointestinal (GI) inflammation (faecal calprotectin), GI symptoms, and stool habits. We conducted in vitro experiments and used a gut model system to explore potential inhibition of alpha-amylase. We gained qualitative insight into participant experiences of using WKBE via focus groups. WKBE supplementation decreased the relative abundance of Bacteroidetes and increased that of Firmicutes, however, there were no significant differences in post-intervention gut microbiota measurements between the WKBE and control. There were no significant effects on GI inflammation or symptoms related to constipation, or stool consistency or frequency. Our in vitro and gut model system analyses showed no effects of WKBE on alpha-amylase activity. Our findings suggest that WKBE may modulate the gut microbiota in healthy adults, however, the underlying mechanism is unlikely due to active site inhibition of alpha-amylase.
This chapter identifies an alternative trajectory for tracing Alain Locke’s role in shaping the New Negro movement of the 1920s. As argued, Locke’s development as a theorist and architect of the New Negro movement can be traced back to the first decade of the twentieth century when Locke “swerved” away from the notion of the individual artist as “genius.” Locke found inspiration in Paul Laurence Dunbar, who himself had moved away from the notion of artist as genius to that of artist as “representative poet.” In particular, through this engagement with Dunbar, Locke formulated a notion of a race tradition rooted in intellectual influence and in the cultural and literary material that constitute an archive, which could stand in for an absent independent physical nation. This innovative notion laid the groundwork for the definition of the modern artist of the twentieth century, launching, in effect, a new theory of literature and the work that it does in the world.
Worldwide, tobacco smoke is still the leading cause of preventable morbidity and mortality. Many smokers develop chronic smoking-related conditions that require emergency department (ED) visits. However, best practices for ED smoking cessation counselling are still unclear.
A randomized controlled trial was conducted to determine whether an “ask, advise, and refer” approach increases 12-month, 30-day quit rates in the stable adult ED smoking population compared to usual care. Patients in the intervention group were referred to a community counselling service that offers a quitline, a text-based program, and a Web-based program. Longitudinal intention-to-treat analyses were performed.
From November 2011 to March 2013, 1,295 patients were enrolled from one academic tertiary care ED. Six hundred thirty-five were allocated to usual care, and 660 were allocated to intervention. Follow-up data were available for 70% of all patients at 12 months. There was no statistically significant difference in 12-month, 30-day quit rates between the two groups. However, there was a trend towards higher 7-day quit attempts, 7-day quit rates, and 30-day quit rates at 3, 6, and 12 months in the intervention group.
In this study, there was a trend towards increased smoking cessation following referral to a community counselling service. There was no statistically significant difference. However, if ED smoking cessation efforts were to provide even a small positive effect, such an intervention may have a significant public health impact given the extensive reach of emergency physicians.
In an America that prided itself on its exceptionalism, it was the Negro who was the most important exception to American citizenship. Unlike other Americans, with the exception of the Native Americans, African Americans had to wait until the passage of the Fourteenth Amendment in 1867, two hundred years after first arriving in North America, to become citizens, and wait another hundred years before they could exercise the rights of citizens everywhere in the nation. Because America has prided itself on its self-proclaimed pluralism, its justly lauded achievement of blending together so many diverse peoples into a common culture, some questions remained. What about the Negro? How could the Negro enter into an American notion of citizenship that was predicated on immigrants becoming “white” by defining themselves as “not black?” How could black people become citizens if black exclusion was the very ground of citizenship for others? Frederick Douglass perhaps put it best. Douglass asserted that Lincoln was a great man and the father of the new white nation that came into being with the Civil War. But the Negro was only Lincoln's stepchild, a fatherless child who had to find his or her own way into a citizenship alone. What was simply a passing anomaly to the rest of Americans marching to the drumbeat of celebratory democracy became, for the black citizen, what Henry James called a complex fate – for to forge a Negro into an American citizen would require that both America and the Negro be changed.
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