Knowledge graphs have become a common approach for knowledge representation. Yet, the application of graph methodology is elusive due to the sheer number and complexity of knowledge sources. In addition, semantic incompatibilities hinder efforts to harmonize and integrate across these diverse sources. As part of The Biomedical Translator Consortium, we have developed a knowledge graph–based question-answering system designed to augment human reasoning and accelerate translational scientific discovery: the Translator system. We have applied the Translator system to answer biomedical questions in the context of a broad array of diseases and syndromes, including Fanconi anemia, primary ciliary dyskinesia, multiple sclerosis, and others. A variety of collaborative approaches have been used to research and develop the Translator system. One recent approach involved the establishment of a monthly “Question-of-the-Month (QotM) Challenge” series. Herein, we describe the structure of the QotM Challenge; the six challenges that have been conducted to date on drug-induced liver injury, cannabidiol toxicity, coronavirus infection, diabetes, psoriatic arthritis, and ATP1A3-related phenotypes; the scientific insights that have been gleaned during the challenges; and the technical issues that were identified over the course of the challenges and that can now be addressed to foster further development of the prototype Translator system. We close with a discussion on Large Language Models such as ChatGPT and highlight differences between those models and the Translator system.

This study explored the effects ofstructural and experiential neighborhood factors and developmental stage on antisocial behavior,among a sample of poor urban adolescents in New York City. Conceptually and empiricallydistinct profiles of neighborhood experience were derived from the data, based on measures ofperceived neighborhood cohesion, poverty-related hassles, and involvement in neighborhoodorganizations and activities. Both the profiles of neighborhood experience and a measure ofcensus-tract-level neighborhood hazard (poverty and violence) showed relationships to antisocialbehavior. Contrary to expectation, higher levels of antisocial behavior were reported amongadolescents residing in moderate-structural-risk neighborhoods than those in high-structural-riskneighborhoods. This effect held only for teens in middle (not early) adolescence and was strongerfor teens perceiving their neighborhoods as hassling than for those who did not. Implications forfuture research and preventive intervention are discussed.

In 1785 physician-politician David Ramsay of Charleston published The History of the Revolution of South Carolina. Contemporaries praised it highly. Four years later Ramsay produced a more ambitious work, The History of the American Revolution. It established his reputation both in America and abroad as the new nation's leading historian. Thus in a few short years Ramsay went from a locally prominent physician and State legislator to an important national cultural and literary figure. The American reading public found his approach to history to its tastes. He expressed a set of ideas about American history in general and the Revolution in particular that were common currency in the United States. But he expressed them for the first time in well-reasoned and documented historical narrative: in volumes that were suitably pro-American, yet judicious in their treatment of Britain, that made a strong case for American uniqueness while maintaining the ideal of the United States as a model for the world.

Ramsay's histories alone would attract our interest as the first and most influential historical analysis of the American Revolution and the ratification of the Federal Constitution. But Ramsay's writings and his career as physician and politician are also significant because they launch us upon a journey into the mind of one of the new nation's most articulate spokesmen on historical, political, and medical issues. There is, to be sure, little in the general pattern of his life to distinguish him from a number of his contemporaries among the professions and political figures of second rank. Ramsay seldom formulated original ideas. His importance was not simply, or even primarily, that of a political or historical philosopher or medical innovator.