Titanium clips (TC) have previously been successfully used for dural repair and closure in spinal surgeries. Meanwhile, minimally invasive spine surgery (MIS) has widely expanded its indications. At our institution, MIS has become the preferred approach for most spine intradural lesions. While the technique has yielded favorable clinical outcomes, we have successfully incorporated the use of TC for dura closure as an alternative to traditional suturing. This technical note outlines the step-by-step application of TC for duroplasty and emphasizes the factors that make their use advantageous in MIS. We present our experience and discuss relevant literature and key nuances.