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Adopting policies that promote health for the entire biosphere (One Health) requires human societies to transition towards a more sustainable food supply as well as to deepen the understanding of the metabolic and health effects of evolving food habits. At the same time, life sciences are experiencing rapid and groundbreaking technological developments, in particular in laboratory analytics and biocomputing, placing nutrition research in an unprecedented position to produce knowledge that can be translated into practice in line with One Health policies. In this dynamic context, nutrition research needs to be strategically organised to respond to these societal expectations. One key element of this strategy is to integrate precision nutrition into epidemiological research. This position article therefore reviews the recent developments in nutrition research and proposes how they could be integrated into cohort studies, with a focus on the Swiss research landscape specifically.
To identify the informatics educational needs of clinical and translational research professionals whose primary focus is not informatics.
Introduction:
Informatics and data science skills are essential for the full spectrum of translational research, and an increased understanding of informatics issues on the part of translational researchers can alleviate the demand for informaticians and enable more productive collaborations when informaticians are involved. Identifying the level of interest in different topics among various types of of translational researchers will help set priorities for development and dissemination of informatics education.
Methods:
We surveyed clinical and translational science researchers in Clinical and Translational Science Award (CTSA) programs about their educational needs and preferences.
Results:
Researchers from 23 out of the 62 CTSA hubs responded to the survey. 67% of respondents across roles and topics expressed interest in learning about informatics topics. There was high interest in all 30 topics included in the survey, with some variation in interest depending on the role of the respondents.
Discussion:
Our data support the need to advance training in clinical and biomedical informatics. As the complexity and use of information technology and data science in research studies grows, informaticians will continue to be a limited resource for research collaboration, education, and training. An increased understanding of informatics issues across translational research teams can alleviate this burden and allow for more productive collaborations. To inform a roadmap for informatics education for research professionals, we suggest strategies to use the results of this needs assessment to develop future informatics education.
In this study, we conducted the first energy dispersive x-ray diffraction (EDXRD) experiments on Li/Li1.1V3O8 coin cells discharged to different lithiation levels in order to investigate the phase transitions upon electrochemical reduction. The phase transformation from layered Li-poor α to Li-rich α to defect rock-salt β phase was confirmed with cells of different lithiation stages. No spatial localization of phase formation was observed throughout the cathodes under the conditions of this measurement.
Metal hydrides present a feasible means of energy storage and hydrogen sensing but have several performance criteria that must be addressed, including the hysteresis effect during hydrogen loading and unloading. We present the results of a theoretical and experimental study which demonstrates the possibility to control or eliminate hysteresis during metal-hydride transformation in epitaxial Pd thin films. Theoretical analysis predicts stabilization of two-phase metal-hydride state in film due to its elastic interaction with the substrate. It is shown, by atomic force and scanning electron microscopy, that transformation in 100nm thick epitaxial Pd films on Al2O3 substrate proceeds by the formation of transversely modulated two-phase nanostructure. Morphology and crystallographic orientation of the metal-hydride interface corresponds to the theoretically predicted characteristics of coherent phases.
One-dimensional dynamics owns many deep results and avenues of active mathematical research. Numerous inroads to this research exist for the advanced undergraduate or beginning graduate student. This book provides glimpses into one-dimensional dynamics with the hope that the results presented illuminate the beauty and excitement of the field. Much of this material is covered nowhere else in textbook format, some are mini new research topics in themselves, and novel connections are drawn with other research areas both inside and outside the text. The material presented here is not meant to be approached in a linear fashion. Readers are encouraged to pick and choose favourite topics. Anyone with an interest in dynamics, novice or expert alike, will find much of interest within.
A heterophase polydomain structure has been recently discovered in BiFeO3 epitaxial ferroelectric films, which provides large electromechanical responses. In this work, the formation of such a microstructure is explained by theory of elastic domains. The thermodynamics of the heterophase polydomain microstructure is analyzed to predict the equilibrium volume fraction of domains at different film-substrate lattice misfits. Extrinsic mechanical and piezoelectric properties are discussed for the heterophase polydomains. It is shown that an applied electric field, which increases electrostatic interaction between domains, may lead to dramatic increase of piezo response. The results of this work are in good agreement with experimental data for BiFeO3.
Born in Ireland in the mid-nineteenth century, Agnes Mary Clerke achieved fame as the author of A History of Astronomy during the Nineteenth Century. Through her quarter-century career, she became the leading commentator on astronomy and astrophysics in the English-speaking world. The biography of Agnes Clerke describes the life and work of this extraordinary woman. It also chronicles the development of astronomy in the last decades of pre-Einstein science, and introduces many of the great figures in astronomy of that age including Huggins, Lockyer, Holden and Pickering; their achievements and their rivalries. The story follows her friendship with William and Margaret Huggins, and her prolific correspondence with eminent astronomers of the time. This biography will fascinate scientists, and anyone who admires intellectual achievement brought about through love of learning and sheer hard work.
Summary. Stony clays, comprising weathered bryzoan-rich chert and silica clay, are found adjacent to Carboniferous Limestone on the west and a weathered dolomitized zone on the east near Birr, County Offaly, Ireland. A gravity survey together with a stratigraphy obtained from boreholes and other test borings suggests a depth of about 40 m and a surface width or diameter of approximately 60 m for the deposit. Indirect evidence points to a possible Tertiary age. The interpreted origin of the stony clays is by silification of Carboniferous Limestone and preservation by solution subsidence along a possible fault zone.
The Lower Palaeozoic strata west of the Leinster Granite in eastern Ireland, normally referred to as Ordovician, are mainly a greywacke sequence which lithologically resembles undoubted Silurian rocks elsewhere to the north and west. A scanty fauna occurs which could be either Ordovician or Silurian.
Abundance data, determined by epithermal neutron activation analysis, are reported for radioelements in the northern units of the Leinster granite. Compared to similar data for silicic igneous rocks and British Caledonian granites, the Leinster granite shows normal U and K contents but is low in Th. Inter-element correlations and fission-track results suggest that most Th and up to 40% of the U is bound in resistate accessory phases (zircon, sphene, apatite), but that the bulk of U is associated with late-stage alteration products and is located at interstitial labile sites within the host-rock matrix. Mobilization of U located at such sites in the Leinster granite by hydrothermal leaching could lead to redeposition and enrichment in marginal sediments of Old Red Sandstone or younger age.
Iron-platinum (FePt) nano-particles were synthesized using a hot metal salt reduction reaction with iron chloride and platinum acetylacetonate as the precursor salts. The synthesis route was based upon work done previously by Sun et Al.[6]. The size and composition of the FePt nano-particles were controlled by varying the surfactant to reagent molar ratio and refluxing time during synthesis. The average size of FePt nano-particles synthesized ranged from 4.08 nm to 5.23 nm. The composition of the nano-particles ranged from Fe60Pt40 to Fe55Pt45. The size was shown to increase as the surfactant to reagent molar ratio was changed from 1:6 to 1:1. The platinum composition increased from 40 % to 45 % with an increase in the refluxing time from 30 minutes to 60 minutes. The X-ray analysis (XRD) showed that the unannealed nano-particles had a FCC crystal structure. The FCC FePt nano-particles were superparamagnetic at room temperature. A blocking temperature (Tb) of 35 K was measured for 5.23 nm Fe55Pt45 nano-particles. Annealing of the Fe55Pt45 nano-particles induced a FCT crystal structure with hard-magnetic properties. Coercivity (Hc) of approximately 13000 Oe was measured at room temperature.
(a) Department of Chemical and Materials Engineering, San Jose State University
(b) Department of Physics and Astronomy, San Jose State University
(c) Department of Biological Sciences, San Jose State University
One-dimensional dynamics owns many deep results and avenues of active mathematical research. Numerous inroads to this research exist for the advanced undergraduate or beginning graduate student. It is precisely these students whom we target. Several glimpses into one-dimensional dynamics are provided with the hope that the results presented illuminate the beauty and excitement of the field. Many topics covered appear nowhere else in “textbook format,” some are mini new research topics in themselves, and for nearly all topics we try to provide novel connections with other research areas both inside and outside the text. Among these topics are kneading theory and Hofbauer towers; detailed structure of ω-limit sets; topological entropy; lapnumbers and Markov extensions; the 2∞ map (Feigenbaum- Coullet-Tresser), interplay amongst continued fractions, adding machines, circle maps, and unimodal maps; irrational rotations as factors of unimodal maps; connections between β-transformations and unimodal maps; Ledrappier's three-dot example; and itineraries for complex quadratic maps and Hubbard trees. The flavor is largely combinatoric, symbolic, and topological. The material presented is notmeant to be approached in a linear fashion. Rather, we strongly encourage readers to pick and choose topics of interest. Trail routes (other than n ↦ n + 1) are indicated in Figure 1; more explicit information is provided at the beginning of each chapter. Suggested uses for the text include: dynamics courses, master theses, reading courses, research experiences for undergraduates (REUs), seminars, senior projects, and summer courses.
As mentioned, the topics covered are notthe typical topics seen in undergraduate/graduate dynamics texts. Rather, the material is a filtering from the research literature of currently active topics that can be made accessible to the targeted student audience.
Complex dynamics (i.e., the theory of dynamical systems on the complex plane) is a rich area in which powerful techniques from complex analysis are available. In our presentation, we try to avoid the more involved techniques as much as possible. Therefore, we work in settings that allow simplified definitions and theorems yet still allow for challenging results. For example, our definition of Julia sets (Section 14.1) is only valid for polynomials, not for arbitrary analytic functions on ℂ. Comprehensive introductions can be found in [9, 50, 53, 64, 118, 121].
We only discuss quadratic polynomials on ℂ because they are the straightforward, and the most frequently studied, complexifications of unimodal maps. Our goal is to introduce and study symbolic dynamics of them. Just as in the real case, symbolic approaches give a lot of information on the various dynamical behaviors that the system can exhibit. In principle, itineraries can be defined for complex quadratic maps just the same as for real unimodal maps. The difficulty is that the Julia set, the set on which interesting dynamics take place, is much more complicated than the interval. Instead of just “left of the critical point” and “right of critical point,” we need to be much more inventive to decide on which side of the critical point points lie. To make this decision, we will introduce the notion of external rays and external angles. At that point, we will want to determine the external angle of a given point in the Julia set. This is the contents of Section 14.1.