Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
  1. Home
  2. Search

Refine search

Refine search

Access:
Content type:
Publication date:
Apply   From and To filters
Subject: Show more
Journals Show more
Publishers: Show more
Societies Show more
Series: Show more
Collections: Show more

Actions for selected content:

Select all | Deselect all
  • View selected items
  • Export citations
  • Download PDF (zip)
  • Save to Kindle
  • Save to Dropbox
  • Save to Google Drive

Save Search

You can save your searches here and later view and run them again in "My saved searches".

Please provide a title, maximum of 40 characters.
Cancel
×

8 results

  • Pilot study of a combined genomic and epidemiologic surveillance program for hospital-acquired multidrug-resistant pathogens across multiple hospital networks in Australia

  • Part of
  • Norelle L. Sherry, Robyn S. Lee, Claire L. Gorrie, Jason C. Kwong, Rhonda L. Stuart, Tony M. Korman, Caroline Marshall, Charlie Higgs, Hiu Tat Chan, Maryza Graham, Paul D.R. Johnson, Marcel J. Leroi, Caroline Reed, Michael J. Richards, Monica A. Slavin, Leon J. Worth, Benjamin P. Howden, M. Lindsay Grayson
  • Journal:
    Infection Control & Hospital Epidemiology / Volume 42 / Issue 5 / May 2021
    Published online by Cambridge University Press:
    26 November 2020, pp. 573-581
    Print publication:
    May 2021
    • Article
      • You have access
    • PDF
    • HTML
    • Export citation
  • Objectives:

    To conduct a pilot study implementing combined genomic and epidemiologic surveillance for hospital-acquired multidrug-resistant organisms (MDROs) to predict transmission between patients and to estimate the local burden of MDRO transmission.

    Design:

    Pilot prospective multicenter surveillance study.

    Setting:

    The study was conducted in 8 university hospitals (2,800 beds total) in Melbourne, Australia (population 4.8 million), including 4 acute-care, 1 specialist cancer care, and 3 subacute-care hospitals.

    Methods:

    All clinical and screening isolates from hospital inpatients (April 24 to June 18, 2017) were collected for 6 MDROs: vanA VRE, MRSA, ESBL Escherichia coli (ESBL-Ec) and Klebsiella pneumoniae (ESBL-Kp), and carbapenem-resistant Pseudomonas aeruginosa (CRPa) and Acinetobacter baumannii (CRAb). Isolates were analyzed and reported as routine by hospital laboratories, underwent whole-genome sequencing at the central laboratory, and were analyzed using open-source bioinformatic tools. MDRO burden and transmission were assessed using combined genomic and epidemiologic data.

    Results:

    In total, 408 isolates were collected from 358 patients; 47.5% were screening isolates. ESBL-Ec was most common (52.5%), then MRSA (21.6%), vanA VRE (15.7%), and ESBL-Kp (7.6%). Most MDROs (88.3%) were isolated from patients with recent healthcare exposure.

    Combining genomics and epidemiology identified that at least 27.1% of MDROs were likely acquired in a hospital; most of these transmission events would not have been detected without genomics. The highest proportion of transmission occurred with vanA VRE (88.4% of patients).

    Conclusions:

    Genomic and epidemiologic data from multiple institutions can feasibly be combined prospectively, providing substantial insights into the burden and distribution of MDROs, including in-hospital transmission. This analysis enables infection control teams to target interventions more effectively.

  • 16 - Structure and Configuration of Mercury’s Magnetosphere

  • Edited by Sean C. Solomon, Larry R. Nittler, Carnegie Institution of Washington, Washington DC, Brian J. Anderson
  • Book:
    Mercury
    Published online:
    10 December 2018
    Print publication:
    20 December 2018, pp 430-460

  • Summary

    Mercury is the only terrestrial planet other than Earth that possesses a global magnetic field, and the unique solar wind environment of the inner heliosphere has profound consequences for both the structure and dynamics of its magnetosphere. The first in situ observations of Mercury and its space environment made four decades ago by the Mariner 10 spacecraft revealed a magnetic field that is sufficiently strong to stand off the solar wind and form a magnetosphere. Many new insights into Mercury’s magnetosphere were enabled by data returned by the MESSENGER spacecraft. The extensive magnetic field and particle observations allowed detailed characterization of the magnetospheric structure and configuration. MESSENGER magnetic field observations definitively determined the orientation, moment, and location of the internal planetary magnetic dipole field. Furthermore, these observations established the configuration of the magnetopause, bow shock, and magnetospheric current systems. Plasma observations revealed the distribution and composition of plasma in the magnetosphere. We review the geometry and dominant physical processes of Mercury’s unique magnetosphere inferred from MESSENGER data, including the solar wind environment, the shape and location of magnetospheric boundaries, and the fundamental regions and configuration of the magnetosphere and transport and heating of plasma therein. 

  • 17 - Mercury’s Dynamic Magnetosphere

  • Edited by Sean C. Solomon, Larry R. Nittler, Carnegie Institution of Washington, Washington DC, Brian J. Anderson
  • Book:
    Mercury
    Published online:
    10 December 2018
    Print publication:
    20 December 2018, pp 461-496

  • Summary

    MESSENGER’s exploration of Mercury has led to many important discoveries and a global perspective on its magnetosphere, exosphere, and interior as a coupled system. Mercury’s proximity to the Sun, weak planetary magnetic field, electrically conducting core, and sodium-dominated exosphere give rise to a highly dynamic magnetosphere unlike that of any other planet. The strong interplanetary magnetic fields so close to the Sun result in a high rate of energy transfer from the solar wind into Mercury’s magnetosphere. Surprisingly, direct solar wind impact on the surface during coronal mass ejection impact has been found to be infrequent.  Electric currents induced in Mercury’s highly conducting interior buttress the weak planetary magnetic field against direct impact for all but the strongest solar events. Kinetic effects associated with the large orbits of planetary ions about the magnetic field and the small dimensions of the magnetosphere are observed to significantly affect some fluid instabilities such as Kelvin-Helmholtz waves along the magnetopause. As at Earth, magnetic reconnection, dipolarization fronts, and plasmoid ejection are closely associated with substorms in Mercury’s magnetosphere, and MESSENGER frequently observed energetic electrons with energies of tens of to several hundred thousand electron volts. However, no “Van Allen” radiation belts with durable trapping are present.

  • Diagnosing mild cognitive impairment – a data-driven approach

  • N Kochan, P Sachdev, J Trollor, H Brodaty, M Slavin
  • Journal:
    Acta Neuropsychiatrica / Volume 18 / Issue 6 / December 2006
    Published online by Cambridge University Press:
    24 June 2014, p. 257
    • Article
      • You have access
    • PDF
    • HTML
    • Export citation

  • Impairment in instrumental activities of daily living with high cognitive demand is an early marker of mild cognitive impairment: the Sydney Memory and Ageing Study

  • S. Reppermund, H. Brodaty, J. D. Crawford, N. A. Kochan, B. Draper, M. J. Slavin, J. N. Trollor, P. S. Sachdev
  • Journal:
    Psychological Medicine / Volume 43 / Issue 11 / November 2013
    Published online by Cambridge University Press:
    11 January 2013, pp. 2437-2445
  • Background

    Criteria for mild cognitive impairment (MCI) consider impairment in instrumental activities of daily living (IADL) as exclusionary, but cross-sectional studies suggest that some high-level functional deficits are present in MCI. This longitudinal study examines informant-rated IADL in MCI, compared with cognitively normal (CN) older individuals, and explores whether functional abilities, particularly those with high cognitive demand, are predictors of MCI and dementia over a 2-year period in individuals who were CN at baseline.

    Method

    A sample of 602 non-demented community dwelling individuals (375 CN and 227 with MCI) aged 70–90 years underwent baseline and 24-month assessments that included cognitive and medical assessments and an interview with a knowledgeable informant on functional abilities with the Bayer Activities of Daily Living Scale.

    Results

    Significantly more deficits in informant-reported IADL with high cognitive demand were present in MCI compared with CN individuals at baseline and 2-year follow-up. Functional ability in CN individuals at baseline, particularly in activities with high cognitive demand, predicted MCI and dementia at follow-up. Difficulties with highly cognitively demanding activities specifically predicted amnestic MCI but not non-amnestic MCI whereas those with low cognitive demand did not predict MCI or dementia. Age, depressive symptoms, cardiovascular risk factors and the sex of the informant did not contribute to the prediction.

    Conclusions

    IADL are affected in individuals with MCI, and IADL with a high cognitive demand show impairment predating the diagnosis of MCI. Subtle cognitive impairment is therefore likely to be a major hidden burden in society.

  • Skin tests with influenza virus

  • R. B. Habershon, M. E. Molyneux, G. Slavin, G. Loewi, D. A. J. Tyrrell
  • Journal:
    Journal of Hygiene / Volume 71 / Issue 4 / December 1973
    Published online by Cambridge University Press:
    15 May 2009, pp. 755-760
    • Article
      • You have access
    • PDF
    • Export citation

  • Skin reactions have been produced in normal subjects by the injection of highly purified influenza A and B viruses. The reactions reached a maximum at 24–48 hr. and the histological pattern was compatible with a delayed hypersensitivity reaction. There was no close relation between skin test results and circulating antibodies. Twenty-seven subjects were challenged intranasally with attenuated influenza A (H3N2): 5 of 14 skin-test-negative subjects were infected, but none of 13 skin-test-positive subjects.