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334 results

Page 1 of 17

Neurosurgery
  • Beyond the Cutting Edge
  • Edited by Benjamin Hartley, Philip E. Stieg, Rohan Ramakrishna, Michael L. J. Apuzzo
  • Coming soon
  • Expected online publication date:
    August 2025
    Print publication:
    18 September 2025
  • Neurosurgery is seen as 'inaccessible' to those on the outside, even though collaboration with a variety of non-neurosurgeons is essential to advancing the field. Thus, this book answers important questions for those interested in surgery of the brain: What is the current state of affairs? Where is the field going? And, importantly, how can I be involved? A work of far-reaching appeal, this book explores the evolution and future of brain surgery, detailing key technologies that have and will shape the field of neurosurgery. Readers are led on a journey covering over five thousand years of neurosurgical history, from trepanation in Neolithic France to the understanding of neuroanatomy and finally the technological leaps in the 20th and 21st centuries. Advances such as artificial intelligence, nanotechnology, microscopy, robotics are discussed by the world's leading experts, providing non-neurosurgical readers with a framework for how they can be involved in this thrilling field.

  • Outpatient antibiotic stewardship during the COVID-19 era: analysis of prescribing trends and guideline compliance

  • Minji Sohn, Benjamin Pontefract, Kushal Dahal, Michael Klepser
  • Journal:
    Antimicrobial Stewardship & Healthcare Epidemiology / Volume 5 / Issue 1 / 2025
    Published online by Cambridge University Press:
    04 August 2025, e168
    • Article
      • You have access
      • Open access
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  • Objective:

    To analyze antibiotic prescribing trends and guideline concordance in outpatient settings using electronic health records (EHRs).

    Design:

    This quality improvement study utilized data from the Collaboration to Harmonize Antimicrobial Registry Measures (CHARM) database, which integrates antibiotic prescribing data extracted from the EHRs of various outpatient facilities.

    Setting:

    The study was conducted across 352 outpatient facilities in the United States.

    Participants:

    The study included oral antibiotic prescribing data from outpatient encounters from January 2021 to June 2023, encompassing 823,938 prescriptions.

    Methods:

    The primary outcomes were the rate of antibiotic prescribing per 1 000 prescription-related outpatient visits and identifying frequently prescribed antibiotics in adults and children. Secondary outcomes were the prescribing patterns for selected diagnoses and the concordance of these prescriptions with published guidelines.

    Results:

    The study estimated approximately a 20% increase in antibiotic prescribing per year, with an overall rate of 121.26 prescriptions per 1 000 prescription-related outpatient visits (95% confidence interval 121.01–121.50). Amoxicillin-clavulanate, amoxicillin, doxycycline, and cephalexin were most frequently prescribed. Sinusitis and otitis media were the most common reasons for prescribing antibiotics among adults and children, respectively. Less than 60% of sinusitis-related prescriptions were antibiotic concordant. Duration concordance rates were less than 70% for sinusitis, urinary tract infections, cellulitis, and Group A Streptococci. 51% of ciprofloxacin prescriptions were for patients aged 60 or older.

    Conclusions:

    The findings stress the need for strengthened antimicrobial stewardship in outpatient settings. The increasing rate of antibiotic prescriptions and discrepancies in guideline concordance reiterate the importance of ongoing monitoring and targeted interventions.

Principles of Medicine in Africa
  • 5th edition
  • Edited by David Mabey, Martin W. Weber, Moffat Nyirenda, Dorothy Yeboah-Manu, Jackson Orem, Laura Benjamin, Michael Marks, Nicholas A. Feasey
  • Published online:
    18 June 2025
    Print publication:
    05 June 2025
  • Principles of Medicine in Africa combines clinical medicine with a rich understanding of the major environmental and cultural influences on health and disease, providing comprehensive guidance for anyone intending to practise medicine in Africa. Presenting disease in the context of family and culture, the effects of inequality and problems of limited resources are addressed. The authors have a wealth of experience in front line healthcare in Africa and provide practical, evidence-based management guidelines for all the common and less common conditions likely to be encountered. This fifth edition has been thoroughly updated to incorporate the latest research findings and management guidelines and there has been much greater involvement of African physicians in the writing and editorial process. The chapters on cancer and non-communicable diseases have been expanded and new chapters have been added on digital health, critical care in a resource-limited setting, antimicrobial resistance, COVID-19 and other emerging infectious diseases.

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