5 results
P153: The CIMA-Q and CompAS cohort studies on factors associated with Alzheimer's disease (AD): Exploring sociodemographic, health and neuropsychological profile of Subjective Cognitive Decline (SCD) participants from two culturally differentiated samples.
- Sonali Arora, Campos-Magdaleno Maria, Fátima Fernández-Feijoo, Alba Felpete, Samira Mellah, Sylvie Bellevile, Onésimo Juncos, Arturo X Pereiro, CIMA-Q
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- Journal:
- International Psychogeriatrics / Volume 35 / Issue S1 / December 2023
- Published online by Cambridge University Press:
- 02 February 2024, pp. 269-272
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Objective:
To explore commonalities and differences in the sociodemographic, health, and neuropsychological characteristics of participants with SCD recruited in two culturally differentiated cohort studies, namely CIMA-Q (Canada; Bellevile et al., 2019) and CompAS (Spain; Juncos et al., 2012).
Methods:Older adults with subjective cognitive complaints of the CompAS (N=251; 68.92% women; Control: 30.3%; SCD: 25.9%; MCI: 28.7%) and the CIMA-Q (N=179; 71.5% women; Control:16.1%; SCD: 36.8%; MCI:28.6%) were recruited, respectively, from primary care centers and memory clinics, excluding patients with dementia and other neurological or psychiatric disturbances. Cognitive complaints were assessed considering coincident items of the QAM and MFE questionnaires. Cut-off points for the 5%ile were calculated independently in both samples and according to this, participants were classified as SCD or controls (CompAS: N= 141; CIMA-Q: N=161) considering complaints relevance at baseline (Pereiro et al., 2021). Participants underwent neuropsychological assessment. Participants diagnosed as Mild Cognitive Impairment (MCI) were excluded from the analysis. Between cohort-studies and inter-group (control, SCD) differences were tested in the sociodemographic, health and neuropsychological measures considered. The Holm-Bonferroni correction was applied to reduce the probability of type I error (p<.003).
Results:Identical cut-off points for 5%ile were obtained in both samples though SCD prevalence was slightly higher in CIMA-Q. For both samples, equivalence between Control and SCD participants in sociodemographic, health, functionality, and neuropsychological measures was observed. Only complaints and depressive symptomatology was significantly higher in SCD participants than in controls in both CompAS and CIMA-Q studies.
Participants of the CIMA-Q, Controls and SCD, showed significantly higher age, cognitive reserve proxies, comorbidity, and better attentional performance than the CompAS participants (see Table 1). CompAS participants, Controls and SCD, showed more neuropsychiatric symptomatology than CIMA-Q participants (see Table 1).
Conclusions:Control and SCD participants showed equivalence on sociodemographic, health, functional, and neuropsychological measures in both studies. However, significant between-sample differences in the two groups, particularly in SCD participants, were observed in sociodemographic, health, cognitive reserve, behavioral and attentional measures. Identification of these factors are critical to analyze the transcultural validity of cognitive complaints in predicting progression to AD.
Table 1 Between group (control, SCD) and Between study (CIMA-Q, CompAS) differences in sociodemographic, health, and cognitive measures
CIMA-Q CompAS Between-studies differences Between-group differences Between-group differences Control SCD Sociodemographics Age NS NS CIMA-Q>CompAS; F(1,124)=22.78; p<.001 CIMA-Q>CompAS; F(1,172)=36.97; p<.001 Gender NS NS NS NS Schooling (years) NS NS NS CIMA-Q>CompAS; F(1,172)=20.74; p<.001 Prof. qualification NS NS CIMA-Q>CompAS; χ24=18.18; p=001 CIMA-Q>CompAS; χ24=33.95; p<001 Cognitive reserve (quartiles) NS NS CIMA-Q>CompAS; χ23=13.57; p=004 CIMA-Q>CompAS;χ23==42.56; p<001 Memory familiar antecedents NS NS NS CIMA-Q>CompAS; χ21==15.03; p<001 Neuropsychology Subjective complaints* SCD>Control; F(1,119)=147.17, p<.001) SCD>Control; F(1,177)=192.87, p<.001 NS NS Charlson Index* SCD>Control; F(1,115)=5.29, p=.023 NS CIMA-Q>CompAS; F(1,123)=394.96; p<.001 CIMA-Q>CompAS; F(1,168)=335.98; p<.001 General cognition NS (MoCA) NS (CAMCOG-R) -- -- GDS-15* SCD>Control; F(1,119)=8.60, p=.004 SCD>Control; F(1,176)=11.97, p<.001 NS NS TMT-A (secs.)* NS NS NS NS TMT-B (secs.)* NS NS CompAS>CIMA-Q; F(1,118)=12.56; p<.001 CompAS>CIMA-Q; F(1,163)=21.74; p<.001 Verbal fluency NS NS NS NS Semantic fluency NS NS NS NS Boston test NS NS NS NS NPI-Q NS NS CompAS>CIMA-Q; F(1,119)=16.68; p<.001 CompAS> CIMA-Q; F(1,162)=24.46; p<.001 Immediate recall (RAVL test) NS NS NS NS Short delay (RAVL test) NS NS NS NS Long delay(RAVL test) NS NS NS NS Intrusions (RAVL test) NS NS NS NS IAVD* NS NS NS NS Note: *On these measures, higher scores denote worse cognition or health condition. TMT: Trail Making Test (A and B forms); NPI-Q: Neuropsychiatric Inventory-Questionnaire; RAVL: Rey Auditory Verbal Learning; IAVD: Instrumental Activity of Daily Living.
P46: Subjective cognitive decline and frailty status: results from the Compostela Ageing Study.
- David Facal, Alba Felpete, Lucía Pérez-Blanco, Ingri Sandoval, Ana Nieto-Vieites, María Campos-Magdaleno, Cristina Lojo-Seoane
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- Journal:
- International Psychogeriatrics / Volume 35 / Issue S1 / December 2023
- Published online by Cambridge University Press:
- 02 February 2024, pp. 241-242
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Objective:
The relationship between objective cognitive performance and physical frailty has been explored in the recent literature and cognitive frailty has emerged as a strong field of study in psychogerontology. However, less is known about the relationship between subjective cognitive status and physical frailty. The aim of this communication is to present the relationships found between subjective cognitive decline and physical frailty in the third wave of the Compostela Aging Study, the first in which frailty status has been studied.
Methods:Cognitive and neuropsychological, functional, and affective assessment was conducted with persons over 50 years of age with subjective memory complaints in the health area of Santiago de Compostela. 149 participants who completed the third wave of the study and who did not present dementia or other serious pathologies were selected. Mild Cognitive Impairment (MCI) was diagnosed according to the current criteria in a special meeting of the research team. In the participants without MCI, the intensity and severity of their complaints were assessed according to the Subjective Cognitive Decline (SCD) criteria. Physical frailty was assessed following the frailty phenotype as described by Fried et al.
Results:Only 4 participants (2.7%) presented physical frailty (3, 4 or 5 criteria in the frailty phenotype). Of those presenting physical pre-frailty (1 or 2 criteria), 36 were MCI (23.8%), 33 SCD (21.9%) and 36 controls. Finally, 40 participants (26.5%) presented no frailty criteria (8 with MCI, 13 with SCD and 19 controls). Participants with SCD and pre-frailty were of intermediate age and they had more years of education than the group with MCI and pre-frailty, although these differences were not significant. They have significantly more symptoms of depression (GDS) and worse mental health status (GHQ-12) than participants without frailty and pre-frailty controls, and more symptoms of anxiety (GAD-7) than participants without frailty.
Conclusion:The relationship between subjective memory complaints and frailty could help to establish groups at special risk of cognitive impairment in phases prior to objective cognitive decline, being these groups particularly optimal targets for preventive intervention. However, a detailed characterization of these subgroups is still required.
Changes in visual memory in mild cognitive impairment: a longitudinal study with CANTAB
- María Campos-Magdaleno, David Leiva, Arturo X. Pereiro, Cristina Lojo-Seoane, Sabela C. Mallo, David Facal, Onésimo Juncos-Rabadán
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- Journal:
- Psychological Medicine / Volume 51 / Issue 14 / October 2021
- Published online by Cambridge University Press:
- 07 May 2020, pp. 2465-2475
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Background
Mild cognitive impairment (MCI), as a stage in the cognitive continuum between normal ageing and dementia, is mainly characterized by memory impairment. The aims of this study were to examine CANTAB measures of temporal changes of visual memory in MCI and to evaluate the usefulness of the baseline scores for predicting changes in cognitive status.
MethodsThe study included 201 participants aged over 50 years with subjective cognitive complaints. Visual memory was assessed with four CANTAB tests [paired associates learning (PAL), delayed matching to sample (DMS), pattern recognition memory (PRM) and spatial span (SSP)] administered at baseline and on two further occasions, with a follow-up interval of 18–24 months. Participants were divided into three groups according to the change in their cognitive status: participants with subjective cognitive complaints who remained stable, MCI participants who remained stable (MCI-Stable) and MCI participants whose cognitive deterioration continued (MCI-Worsened). Linear mixed models were used to model longitudinal changes, with evaluation time as a fixed variable, and multinomial regression models were used to predict changes in cognitive status.
ResultsIsolated significant effects were obtained for age and group with all CANTAB tests used. Interactions between evaluation time and group were identified in the PAL and DMS tests, indicating different temporal patterns depending on the changes in cognitive status. Regression models also indicated that CANTAB scores were good predictors of changes in cognitive status.
ConclusionsDecline in visual memory measured by PAL and DMS tests can successfully distinguish different types of MCI, and considered together PAL, DMS, PRM and SSP can predict changes in cognitive status.
Cognitive reserve and working memory in cognitive performance of adults with subjective cognitive complaints: longitudinal structural equation modeling
- Cristina Lojo-Seoane, David Facal, Joan Guàrdia-Olmos, Arturo X. Pereiro, María Campos-Magdaleno, Sabela C. Mallo, Onésimo Juncos-Rabadán
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- Journal:
- International Psychogeriatrics / Volume 32 / Issue 4 / April 2020
- Published online by Cambridge University Press:
- 24 September 2019, pp. 515-524
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Objective:
To study the influence of cognitive reserve (CR) on cognitive performance of individuals with subjective cognitive complaints (SCCs) within a period of 36 months.
Design:We used a general linear model repeated measures procedure to analyze the differences in performance between three assessments. We used a longitudinal structural equation modeling to analyze the relationship between CR and cognitive performance at baseline and at two follow-up assessments.
Setting:Participants with SCCs were recruited and assessed in primary care health centers.
Participants:A total of 212 participants older than 50 years with SCCs.
Measurements:Cognitive reserve data were collected with an ad hoc questionnaire administered to the subjects in an interview. General cognitive performance (GCP), episodic memory (EM), and working memory (WM) have been evaluated. The Mini-Mental State Examination and the total score of Spanish version of the Cambridge Cognitive Examination evaluated the GCP. Episodic memory was assessed with the Spanish version of the California Verbal Learning. Working memory was evaluated by the counting span task and the listening span task.
Results:The satisfactory fit of the proposed model confirmed the direct effects of CR on WM and GCP at baseline, as well as indirect effects on EM and WM at first and second follow-up. Indirect effects of CR on other cognitive constructs via WM were observed over time.
Conclusion:The proposed model is useful for measuring the influence of CR on cognitive performance over time. Cognitive response acquired throughout life may influence cognitive performance in old age and prevent cognitive deterioration, thus increasing processing resources via WM.
Assessing mild behavioral impairment with the mild behavioral impairment checklist in people with subjective cognitive decline
- Sabela C. Mallo, Zahinoor Ismail, Arturo X. Pereiro, David Facal, Cristina Lojo-Seoane, María Campos-Magdaleno, Onésimo Juncos-Rabadán
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- Journal:
- International Psychogeriatrics / Volume 31 / Issue 2 / February 2019
- Published online by Cambridge University Press:
- 18 July 2018, pp. 231-239
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Objectives:
To estimate the prevalence of Mild Behavioral Impairment (MBI) in people with Subjective Cognitive Decline (SCD), and validate the Mild Behavioral Impairment Checklist (MBI-C) with respect to score distribution, sensitivity, specificity, and utility for MBI diagnosis, as well as correlation with other neuropsychological tests.
Design:Correlational study with a convenience sampling. Descriptive, logistic regression, ROC curve, and bivariate correlations analyses were performed.
Setting:Primary care health centers.
Participants:127 patients with SCD.
Measurements:An extensive evaluation, including Questionnaire for Subjective Memory Complaints, Mini-Mental State Examination, Cambridge Cognitive Assessment-Revised, Neuropsychiatric Inventory-Questionnaire (NPI-Q), the Geriatric Depression Scale-15 items (GDS-15), the Lawton and Brody Index and the MBI-C, which was administered by phone to participants’ informants.
Results:MBI prevalence was 5.8% in those with SCD. The total MBI-C scoring was low and differentiated people with MBI at a cut-off point of 8.5 (optimizing sensitivity and specificity). MBI-C total scoring correlated positively with NPI-Q, Questionnaire for Subjective Cognitive Complaints (QSCC) from the informant and GDS-15.
Conclusions:The phone administration of the MBI-C is useful for detecting MBI in people with SCD. The prevalence of MBI in SCD was low. The MBI-C detected subtle Neuropsychiatric symptoms (NPS) that were correlated with scores on the NPI-Q, depressive symptomatology (GDS-15), and memory performance perceived by their relatives (QSCC). Next steps are to determine the predictive utility of MBI in SCD, and its relation to incident cognitive decline over time.