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In this article, the authors present an analysis of radiocarbon dates from a stratified deposit at the Greek Geometric period settlement of Zagora on the island of Andros, which are among the few absolute dates measured from the period in Greece. The dates assigned to Greek Geometric ceramics are based on historical and literary evidence and are found to contradict absolute dates from the central Mediterranean which suggest that the traditional dates are too young. The results indicate the final period at Zagora, the Late Geometric, should be seen as starting at least a century earlier than the traditional date of 760 BC.
Introduction
The goal of treatment for many persons with cancer is not cure but improvement or maintenance of functioning and well-being during their remaining period of life. This is particularly true for patients with advanced or metastatic cancers. Trials to produce evidence of effectiveness or for regulatory approval may include patient assessments of benefit as well as classical clinical endpoints used in oncology settings. These patient assessments of treatment benefit may or may not be related to the traditional measures of treatment success such as survival, tumor shrinkage, or time to tumor progression. For this reason, additional outcome measures to estimate benefit or risk/benefit trade-offs have been developed. Outcomes measures in this category of health assessment are referred to as patient-reported outcomes (PROs) because they are used to collect data directly from the patient.
It is increasingly recognized that the patient's perspective is unique and represents a valuable contribution to drug evaluation and treatment processes. This is particularly important when studying the effects of treatments on cancer symptoms such as pain and fatigue, outcomes not accurately measured by observers. Recent changes in the health care system have greatly empowered patients who are now considered partners rather than passive consumers. To maximize their contribution, they need to be informed about the outcomes associated with treatment. Patients are not always concerned with the same questions as treating physicians or clinical researchers.
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