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Little is known about environmental factors that may influence associations between genetic liability to suicidality and suicidal behavior.
Methods
This study examined whether a suicidality polygenic risk score (PRS) derived from a large genome-wide association study (N = 122,935) was associated with suicide attempts in a population-based sample of European-American US military veterans (N = 1664; 92.5% male), and whether cumulative lifetime trauma exposure moderated this association.
Results
Eighty-five veterans (weighted 6.3%) reported a history of suicide attempt. After adjusting for sociodemographic and psychiatric characteristics, suicidality PRS was associated with lifetime suicide attempt (odds ratio 2.65; 95% CI 1.37–5.11). A significant suicidality PRS-by-trauma exposure interaction emerged, such that veterans with higher levels of suicidality PRS and greater trauma burden had the highest probability of lifetime suicide attempt (16.6%), whereas the probability of attempts was substantially lower among those with high suicidality PRS and low trauma exposure (1.4%). The PRS-by-trauma interaction effect was enriched for genes implicated in cellular and developmental processes, and nervous system development, with variants annotated to the DAB2 and SPNS2 genes, which are implicated in inflammatory processes. Drug repurposing analyses revealed upregulation of suicide gene-sets in the context of medrysone, a drug targeting chronic inflammation, and clofibrate, a triacylglyceride level lowering agent.
Conclusion
Results suggest that genetic liability to suicidality is associated with increased risk of suicide attempt among veterans, particularly in the presence of high levels of cumulative trauma exposure. Additional research is warranted to investigate whether incorporation of genomic information may improve suicide prediction models.
The coronavirus disease-2019 (COVID-19) pandemic has caused myriad health, social, and economic stressors. To date, however, no known study has examined changes in mental health during the pandemic in the U.S. military veteran population.
Methods
Data were analyzed from the 2019–2020 National Health and Resilience in Veterans Study, a nationally representative, prospective cohort survey of 3078 veterans. Pre-to-peri-pandemic changes in psychiatric symptoms were evaluated, as well as pre-pandemic risk and protective factors and pandemic-related correlates of increased psychiatric distress.
Results
The prevalence of generalized anxiety disorder (GAD) positive screens increased from pre- to peri-pandemic (7.1% to 9.4%; p < 0.001) and was driven by an increase among veterans aged 45–64 years (8.2% to 13.5%; p < 0.001), but the prevalence of major depressive disorder and posttraumatic stress disorder positive screens remained stable. Using a continuous measure of psychiatric distress, an estimated 13.2% of veterans reported a clinically meaningful pre-to-peri-pandemic increase in distress (mean = 1.1 standard deviation). Veterans with a larger pre-pandemic social network size and secure attachment style were less likely to experience increased distress, whereas veterans reporting more pre-pandemic loneliness were more likely to experience increased distress. Concerns about pandemic-related social losses, mental health COVID-19 effects, and housing stability during the pandemic were associated with increased distress, over-and-above pre-pandemic factors.
Conclusions
Although most U.S. veterans showed resilience to mental health problems nearly 1 year into the pandemic, the prevalence of GAD positive screens increased, particularly among middle-aged veterans, and one of seven veterans experienced increased distress. Clinical implications of these findings are discussed.
What is the status of women's writing in German today, in an era when feminism has thoroughly problematized binary conceptions of sex and gender? Drawing on gender and queer theory, including the work of Lauren Berlant, Judith Butler, and Michel Foucault, the essays in this volume rethink conventional ways of conceptualizing female authorship and re-examine the formal, aesthetic, and thematic terms in which "women's literature" has been conceived. With an eye to the literary and feminist legacy of authors such as Christa Wolf and Ingeborg Bachmann, contributors treat the works of many of contemporary Germany's most significant literary voices, including Hatice Akyün, Sibylle Berg, Thea Dorn, Tanja Dückers, Karen Duve, Jenny Erpenbeck, Julia Franck, Katharina Hacker, Charlotte Roche, Julia Schoch, and Antje Rávic Strubel -- authors who, through their writing or their role in the media, engage with questions of what it means to be a woman writer in twenty-first-century Germany. Contributors: Hester Baer, Necia Chronister, Helga Druxes, Valerie Heffernan, Alexandra Merley Hill, Lindsey Lawton, Sheridan Marshall, Beret Norman, Mihaela Petrescu, Jill Suzanne Smith, Carrie Smith-Prei, Maria Stehle, Katherine Stone. Hester Baer is Associate Professor of Germanic Studies at the University of Maryland. Alexandra Merley Hill is Assistant Professor of German at the University of Portland.
We report two cases of respiratory toxigenic Corynebacterium diphtheriae infection in fully vaccinated UK born adults following travel to Tunisia in October 2019. Both patients were successfully treated with antibiotics and neither received diphtheria antitoxin. Contact tracing was performed following a risk assessment but no additional cases were identified. This report highlights the importance of maintaining a high index of suspicion for re-emerging infections in patients with a history of travel to high-risk areas outside Europe.
A panel of experts has produced a Statement of Principles of Christian Law, drawn from an examination of their internal regulatory instruments. These principles are offered for further examination by comparative scholars of church law, as an expression of shared ecclesiology, and in furtherance of the ecumenical endeavour.
These are personal views immediately following upon the publication of the White Paper on Airports Policy and not those of any organisation with which I am associated. They are, however, my views of the national interest.
I would expect there to be considerable disagreement with a White Paper which traverses so many areas where local conflicts abound. No policy could satisfy all on a subject which evokes so great an emotive response from many quarters, and in which even the smallest of pressure groups reacts with frenzied fury against any proposal with which it disagrees.
While regular astronomical image archive searches can find images at a fixed location, they cannot find images of moving targets such as asteroids or comets. The Solar System Object Image Search (SSOIS) at the Canadian Astronomy Data Centre allows users to search for images of moving objects, allowing precoveries. SSOIS accepts as input either an object designation, a list of observations, a set of orbital elements, or a user-generated ephemeris for an object. It then searches for observations of that object over a range of dates. The user is then presented with a list of images containing that object from a variety of archives. Initially created to search the CFHT MegaCam archive, SSOIS has been extended to other telescopes including Gemini, Subaru/SuprimeCam, WISE, HST, the SDSS, AAT, the ING telescopes, the ESO telescopes, and the NOAO telescopes (KPNO/CTIO/WIYN), for a total of 24.5 million images. As the Pan-STARRS and Hyper Suprime-Cam archives become available, they will be incorporated as well. The SSOIS tool is located on the web at http://www.cadc-ccda.hia-iha.nrc-cnrc.gc.ca/en/ssois/.
Edited by
Hester Baer, Associate Professor of Germanic Studies at the University of Maryland,Alexandra Merley Hill, Assistant Professorof German at the University of Portland
Edited by
Hester Baer, Associate Professor of Germanic Studies at the University of Maryland,Alexandra Merley Hill, Assistant Professorof German at the University of Portland
Edited by
Hester Baer, Associate Professor of Germanic Studies at the University of Maryland,Alexandra Merley Hill, Assistant Professorof German at the University of Portland
Edited by
Hester Baer, Associate Professor of Germanic Studies at the University of Maryland,Alexandra Merley Hill, Assistant Professorof German at the University of Portland
Edited by
Hester Baer, Associate Professor of Germanic Studies at the University of Maryland,Alexandra Merley Hill, Assistant Professorof German at the University of Portland
Edited by
Hester Baer, Associate Professor of Germanic Studies at the University of Maryland,Alexandra Merley Hill, Assistant Professorof German at the University of Portland
Edited by
Hester Baer, Associate Professor of Germanic Studies at the University of Maryland,Alexandra Merley Hill, Assistant Professorof German at the University of Portland
The hallmark of a successful response to a nuclear detonation will be the resilience of the community, region, and nation. An incident of this magnitude will rapidly become a national incident; however, the initial critical steps to reduce lives lost, save the lives that can be saved with the resources available, and understand and apply resources available to a complex and dynamic situation will be the responsibility of the local and regional responders and planners. Expectations of the public health and health care systems will be met to the extent possible by coordination, cooperation, and an effort to produce as consistent a response as possible for the victims. Responders will face extraordinarily stressful situations, and their own physical and psychological health is of great importance to optimizing the response. This article illustrates through vignettes and supporting text how the incident may unfold for the various components of the health and medical systems and provides additional context for the discipline-related actions outlined in the state and local planners’ playbook.
(Disaster Med Public Health Preparedness. 2011;5:S73-S88)
For efficient and effective medical responses to mass casualty events, detailed advanced planning is required. For federal responders, this is an ongoing responsibility. The US Department of Health and Human Services (DHHS) prepares playbooks with formal, written plans that are reviewed, updated, and exercised regularly. Recognizing that state and local responders with fewer resources may be helped in creating their own event-specific response plans, subject matter experts from the range of sectors comprising the Scarce Resources for a Nuclear Detonation Project, provided for this first time a state and local planner's playbook template for responding to a nuclear detonation. The playbook elements are adapted from DHHS playbooks with appropriate modification for state and local planners. Individualization by venue is expected, reflecting specific assets, populations, geography, preferences, and expertise. This playbook template is designed to be a practical tool with sufficient background information and options for step-by-step individualized planning and response.
(Disaster Med Public Health Preparedness. 2011;5:S89-S97)
The purpose of this article is to set the context for this special issue of Disaster Medicine and Public Health Preparedness on the allocation of scarce resources in an improvised nuclear device incident. A nuclear detonation occurs when a sufficient amount of fissile material is brought suddenly together to reach critical mass and cause an explosion. Although the chance of a nuclear detonation is thought to be small, the consequences are potentially catastrophic, so planning for an effective medical response is necessary, albeit complex. A substantial nuclear detonation will result in physical effects and a great number of casualties that will require an organized medical response to save lives. With this type of incident, the demand for resources to treat casualties will far exceed what is available. To meet the goal of providing medical care (including symptomatic/palliative care) with fairness as the underlying ethical principle, planning for allocation of scarce resources among all involved sectors needs to be integrated and practiced. With thoughtful and realistic planning, the medical response in the chaotic environment may be made more effective and efficient for both victims and medical responders.
(Disaster Med Public Health Preparedness. 2011;5:S20-S31)