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We present an experiment where subjects sequentially receive signals about the true state of the world and need to form beliefs about which one is true, with payoffs related to reported beliefs. We attempt to control for risk aversion using the Offerman et al. (Rev Econ Stud 76(4):1461–1489, 2009) technique. Against the baseline of Bayesian updating, we test for belief adjustment underreaction and overreaction and model the decision making process of the agent as a double hurdle model where agents with inferential expectations first decide whether to adjust their beliefs and then, if so, decide by how much. We also test the effects of increased inattention and complexity on belief updating. We find evidence for periods of belief inertia interspersed with belief adjustment. This is due to a combination of random belief adjustment; state-dependent belief adjustment, with many subjects requiring considerable evidence to change their beliefs; and quasi-Bayesian belief adjustment, with aggregate insufficient belief adjustment when a belief change does occur. Inattention, like complexity, makes subjects less likely to adjust their stated beliefs, while inattention additionally discourages full adjustment.
Accurate diagnosis of bipolar disorder (BPD) is difficult in clinical practice, with an average delay between symptom onset and diagnosis of about 7 years. A depressive episode often precedes the first manic episode, making it difficult to distinguish BPD from unipolar major depressive disorder (MDD).
Aims
We use genome-wide association analyses (GWAS) to identify differential genetic factors and to develop predictors based on polygenic risk scores (PRS) that may aid early differential diagnosis.
Method
Based on individual genotypes from case–control cohorts of BPD and MDD shared through the Psychiatric Genomics Consortium, we compile case–case–control cohorts, applying a careful quality control procedure. In a resulting cohort of 51 149 individuals (15 532 BPD patients, 12 920 MDD patients and 22 697 controls), we perform a variety of GWAS and PRS analyses.
Results
Although our GWAS is not well powered to identify genome-wide significant loci, we find significant chip heritability and demonstrate the ability of the resulting PRS to distinguish BPD from MDD, including BPD cases with depressive onset (BPD-D). We replicate our PRS findings in an independent Danish cohort (iPSYCH 2015, N = 25 966). We observe strong genetic correlation between our case–case GWAS and that of case–control BPD.
Conclusions
We find that MDD and BPD, including BPD-D are genetically distinct. Our findings support that controls, MDD and BPD patients primarily lie on a continuum of genetic risk. Future studies with larger and richer samples will likely yield a better understanding of these findings and enable the development of better genetic predictors distinguishing BPD and, importantly, BPD-D from MDD.
Single-molecule techniques to analyze proteins and other biomolecules involving labels and tethers have allowed for new understanding of the underlying biophysics; however, the impact of perturbation from the labels and tethers has recently been shown to be significant in several cases. New approaches are emerging to measure single proteins through light scattering without the need for labels and ideally without tethers. Here, the approaches of interference scattering, plasmonic scattering, microcavity sensing, nanoaperture optical tweezing, and variants are described and compared. The application of these approaches to sizing, oligomerization, interactions, conformational dynamics, diffusion, and vibrational mode analysis is described. With early commercial successes, these approaches are poised to have an impact in the field of single-molecule biophysics.
Although effective treatments for bulimic-spectrum eating disorders exist, access is often delayed because of limited therapist availability and lengthy waiting lists. Web-based self-help interventions have the potential to bridge waiting times for face-to-face treatment and overcome existing treatment gaps.
Aims
This study aims to assess the effectiveness of a web-based guided self-help intervention (everyBody Plus) for patients with bulimia nervosa, binge eating disorder and other specified feeding and eating disorders who are waiting for out-patient treatment.
Method
A randomised controlled trial was conducted in Germany and the UK. A total of 343 patients were randomly assigned to the intervention ‘everyBody Plus’ or a waitlist control condition. The primary outcome was the number of weeks after randomisation until a patient achieved a clinically relevant improvement in core symptoms for the first time. Secondary outcomes included eating disorder attitudes and behaviours, and general psychopathology.
Results
At 6- and 12-month follow-up, the probability of being abstinent from core symptoms was significantly larger for the intervention group compared with the control group (hazard ratio: 1.997, 95% CI 1.09–3.65; P = 0.0249). The intervention group also showed larger improvements in eating disorder attitudes and behaviours, general psychopathology, anxiety, depression and quality of life, compared with the control group at most assessment points. Working alliance ratings with the online therapist were high.
Conclusions
The self-help intervention everyBody Plus, delivered with relatively standardised online guidance, can help bridge treatment gaps for patients with bulimic-spectrum eating disorders, and achieve faster and greater reductions in core symptoms.
Making Sense of Mass Education provides a contemporary analysis of the ideas and issues that have traditionally dominated education research, challenging outdated preconceptions with fundamental theory and discussion. It takes a demythologising approach in assessing these issues and their relevance to schooling and education in Australia. This text examines the cultural context of education and the influence of external media and new technologies, and highlights the many forms of discrimination in education, including social class, race and gender. It looks at alternative approaches to education, including the repercussions of gathering data to measure school performance, and considers the intersection of ethics and philosophy in classroom teaching. The fourth edition expands on these issues with three new chapters: on sexuality, children's rights, and neoliberalism and the marketisation of education. Each chapter challenges and breaks down common myths surrounding these topics, encouraging pre-service teachers to think critically and reflect on their own beliefs.
This chapter argues that our subjective experiences ߝ how we experience the world and understand ourselves within it ߝ are just as closely governed as our objective conduct, discussed in the last chapter. Whether they realise it or not, contemporary teachers are expected to play a significant role in this form of regulation. After all, teachers are now not simply responsible for transmitting a given curriculum and keeping children in line; they are de facto psychologists, responsible for the mental health, regulation and development of their pupils.
This chapter argues that the issue of ‘truth’ has played a foundational role, not only within the discipline of philosophy but also within many different aspects of Australian culture. However, there seems to be little agreement on what it really is, and while some philosophers contend that truth is a meaningless concept ߝ a linguistic mirage ߝ most would argue there’s something of importance there ߝ but what is it?Even if we struggle to determine the real nature of truth ߝ as we did with the real nature of right and wrong in Chapter 15 ߝ at least we structure our culture, our knowledges and our school curricula around stuff we know to be unequivocally true … or do we? Arguably, many of the assumptions we make, often derived from five centuries of European colonialism, do not stand up to close scrutiny. They are often ‘truths’ that suit particular interests of the powerful, and subtly act to reinforce their worldview.
The working life of educators ߝ whether in schools or universities ߝ has become dauntingly complex, with the relentless focus on standards and testing, pressure to ensure equitable outcomes, a managerialist working environments, ever-growing professional responsibilities and expectations, increasingly heterogeneous classrooms and fairly relentless media criticism, to name only a fewissues. The job requires continual self-reflection, a commitment to lifelong learning and an ongoing dedication to the profession in order to remain viable at all. Making sense of it all ߝ Making Sense of Mass Education ߝ is not an easy task. Hopefully this book can help a little.
A quick glance through history demonstrates that it has not always been an unbroken chain of human happiness, to put it mildly.Different individuals, groups and peoples have faced persecution for any number of reasons: where they came from, how they looked, their perceived (dis)ability, who or what they believed in, who they loved, how they identified, the family they were born into, or, in some cases, for no reason at all. It is against this backdrop that our current set of human rights has emerged. While this chapter focuses primarilyon children’s rights and their relationship with education and educator obligations, it is necessary to understand the history of rights in order to understand why human rights, and particularly children’s rights, are so important to the work we do as educators.
Of all the ways in which humans have chosen to divide themselves, none has a history as problematic as race. This concept has significant implications for almost every aspect of contemporary human conduct, irrespective of what ‘race’ we identify with, or even are deemed to belong to. This is particularly so in the field of education.
This chapter will look at the complicated history of race as well as some of the current challenges being faced. In order to describe the complex issues within this important area, a wide range of interrelated terms are used. Probably the most important of these terms is the underpinning notion of ‘othering’ ߝ that is, thinking about a certain person or group as not ‘one of us’... as ‘the other’. This important concept is also very relevant to discussions of gender and sexualities, so it is discussed further in Chapter 3.
This chapter makes the case for the importance of philosophy as a discipline in its own right, as a subject area vital to the better understanding of education and as a set of self-reflective practices that can make us better teachers. Philosophy is largely concerned with those areas of study and speculation beyond the reach of empirical analysis, addressing problems about how we construct knowledge, how we produce a just society and how we determine ‘right’ from ‘wrong’. Its central research methodology is simply to think with clarity. The significance of this discipline has not been limited to answering abstract questions about the human condition; philosophy has been instrumental in both making us into rational and reflective citizens and framing the ideas behind our entire system of mass schooling.
More often than not, the advent of contemporary information and communication technologies is presented as one of the great success stories of contemporary schooling, and while ICT has the potential to be a transformative force in education, the issues are complicated and the outcomes far from certain. The field is often divided into those who grew up with such technologies ߝ ‘digital natives’/students ߝ and those who have come to these technologies at a later date ߝ ‘digital immigrants’/teachers. This binary articulates a central problem within a power relation where teachers are normally expected to know more than those they teach. Furthermore, such new technologies do not simply represent mechanisms for accessing more information more quickly and in more interesting ways. By stepping outside the domain of traditional linear texts, traditional understandings of literacy start to lose their meaning. New digital technologies necessitate the adoption of the notion of ‘multiliteracies’, a plural understanding of literacy that encompasses a range of other modes of contemporary meaning-making ߝ hypertext, audio, video and so on ߝ which are integral to the digital universe.
Given that feminist arguments have been around for decades, and that there has been progress towards gender equality, many would argue that concerns over gender have been resolved ߝ a battle won. However, declaring victory in this manner seems very premature. After all, the evidence suggests that a significant number of wider questions still attract attention: just what is gender and what is the best theoretical framework for approaching it? What roles do schools play in its construction? Do we still have to go down the ‘men are to blame for everything’ route? Why should schooling have anything to do with gender identity?
This chapter will unpack the complex and changing relationship between gender and education. In order to accomplish this, it will link each of the most common myths in the area with one of the three waves of feminism that characterised the twentieth century. As with the arguments surrounding social class, it will ultimately be suggested that explanations relying upon a master discourse ߝ not ‘the economy’ again, but in this case patriarchy ߝ a unified system of male domination ߝ are outdated.Similarly, it is argued that the view of gender as a binary of man/woman based on anatomy at birth has had its day.