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The time has come for revising the rules of clozapine blood monitoring in Europe. A joint expert statement from the European Clozapine Task Force
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- Psychosis Spectrum Disorders
- Viewpoints
Hélène Verdoux, Robert A. Bittner, Alkomiet Hasan, Mishal Qubad, Elias Wagner, Alexis Lepetit, Manuel Arrojo-Romero, Christian Bachmann, Marieke Beex-Oosterhuis, Jan Bogers, Andreja Celofiga, Dan Cohen, Domenico de Berardis, Marc de Hert, Carlos de Las Cuevas, Bjørn H. Ebdrup, Konstantinos N. Fountoulakis, Daniel Guinart, Dolores Keating, Miloslav Kopeček, John Lally, Judit Lazáry, Jurjen J. Luykx, Olalla Maronas Amigo, Espen Molden, Jimmi Nielsen, Brian O’Donoghue, Pierre Oswald, Flavian S. Radulescu, Christopher Rohde, Marina Sagud, Emilio J. Sanz, Ivona Šimunović Filipčić, Iris E. Sommer, Heidi Taipale, Jari Tiihonen, Heli Tuppurainen, Selene Veerman, Alina Wilkowska, Edoardo Spina, Peter Schulte
Journal:

European Psychiatry / Volume 68 / Issue 1 / 2025

Published online by Cambridge University Press:

10 January 2025, e17
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The European Clozapine Task Force is a group of psychiatrists and pharmacologists practicing in 18 countries under European Medicines Agency (EMA) regulation, who are deeply concerned about the underuse of clozapine in European countries. Although clozapine is the most effective antipsychotic for people with treatment-resistant schizophrenia, a large proportion of them do not have access to this treatment. Concerns about clozapine-induced agranulocytosis and stringent blood monitoring rules are major barriers to clozapine prescribing and use. There is a growing body of evidence that the incidence of clozapine-induced agranulocytosis is very low after the first year of treatment. Maintaining lifelong monthly blood monitoring after this period contributes to unjustified discontinuation of clozapine. We leverage recent and replicated evidence on the long-term safety of clozapine to call for the revision and updating of the EMA’s blood monitoring rules, thus aiming to overcome this major barrier to clozapine prescribing and use. We believe the time has come for relaxing the rules without increasing the risks for people using clozapine in Europe.

A Criticism of Doyle’s survey of time preference: A correction regarding the CRDI and CADI families
Han Bleichrodt, Rogier J. D. Potter van Loon, Kirsten I. M. Rohde, Peter P. Wakker
Journal:

Judgment and Decision Making / Volume 8 / Issue 5 / September 2013

Published online by Cambridge University Press:

01 January 2023, pp. 630-631
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Doyle’s (2013) theoretical survey of discount functions criticizes two parametric families abbreviated as CRDI and CADI families. We show that Doyle’s criticisms are based on a mathematical mistake and are incorrect.

23 - Attacks on Classical Cryptography
Peter P. Rohde, University of Technology, Sydney
Book:

The Quantum Internet

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09 September 2021

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30 September 2021, pp 187-189
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19 - The Irrelevance of Latency
Peter P. Rohde, University of Technology, Sydney
Book:

The Quantum Internet

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09 September 2021

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30 September 2021, pp 175-176
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55 - Conclusion: The Vision of the Quantum Internet
Peter P. Rohde, University of Technology, Sydney
Book:

The Quantum Internet

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09 September 2021

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30 September 2021, pp 323-325
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41 - Problem Size Scaling Functions
Peter P. Rohde, University of Technology, Sydney
Book:

The Quantum Internet

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09 September 2021

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30 September 2021, pp 270-271
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47 - Economic Implications
Peter P. Rohde, University of Technology, Sydney
Book:

The Quantum Internet

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09 September 2021

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30 September 2021, pp 281-287
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Part IX - Essays
Peter P. Rohde, University of Technology, Sydney
Book:

The Quantum Internet

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09 September 2021

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30 September 2021, pp 303-304
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37 - Rate of Return
Peter P. Rohde, University of Technology, Sydney
Book:

The Quantum Internet

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09 September 2021

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30 September 2021, pp 263-263
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49 - The Era of Quantum Supremacy
Peter P. Rohde, University of Technology, Sydney
Book:

The Quantum Internet

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09 September 2021

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30 September 2021, pp 305-306
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Part X - The End
Peter P. Rohde, University of Technology, Sydney
Book:

The Quantum Internet

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09 September 2021

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30 September 2021, pp 321-322
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Part IV - Entanglement Distribution
Peter P. Rohde, University of Technology, Sydney
Book:

The Quantum Internet

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09 September 2021

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30 September 2021, pp 147-148
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Part III - Protocols for the Quantum Internet
Peter P. Rohde, University of Technology, Sydney
Book:

The Quantum Internet

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09 September 2021

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30 September 2021, pp 87-88
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52 - Security Implications of the Global Quantum Internet
Peter P. Rohde, University of Technology, Sydney
Book:

The Quantum Internet

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09 September 2021

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30 September 2021, pp 313-315
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10 - Interconnecting and Interfacing Quantum Networks
Peter P. Rohde, University of Technology, Sydney
Book:

The Quantum Internet

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09 September 2021

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30 September 2021, pp 78-86
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9 - Routing Strategies
Peter P. Rohde, University of Technology, Sydney
Book:

The Quantum Internet

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09 September 2021

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30 September 2021, pp 75-77
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Part VII - Cloud Quantum Computing
Peter P. Rohde, University of Technology, Sydney
Book:

The Quantum Internet

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09 September 2021

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30 September 2021, pp 225-226
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2 - Mathematical Representation of Networks
Peter P. Rohde, University of Technology, Sydney
Book:

The Quantum Internet

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09 September 2021

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30 September 2021, pp 9-16
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38 - Market Competitiveness
Peter P. Rohde, University of Technology, Sydney
Book:

The Quantum Internet

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09 September 2021

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30 September 2021, pp 264-264
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Part II - Quantum Networks
Peter P. Rohde, University of Technology, Sydney
Book:

The Quantum Internet

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09 September 2021

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30 September 2021, pp 35-36
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The time has come for revising the rules of clozapine blood monitoring in Europe. A joint expert statement from the European Clozapine Task Force

A Criticism of Doyle’s survey of time preference: A correction regarding the CRDI and CADI families

23 - Attacks on Classical Cryptography

19 - The Irrelevance of Latency

55 - Conclusion: The Vision of the Quantum Internet

41 - Problem Size Scaling Functions

47 - Economic Implications

Part IX - Essays

37 - Rate of Return

49 - The Era of Quantum Supremacy

Part X - The End

Part IV - Entanglement Distribution

Part III - Protocols for the Quantum Internet

52 - Security Implications of the Global Quantum Internet

10 - Interconnecting and Interfacing Quantum Networks

9 - Routing Strategies

Part VII - Cloud Quantum Computing

2 - Mathematical Representation of Networks

38 - Market Competitiveness

Part II - Quantum Networks

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82 results