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Diets varying in SFA and MUFA content can impact glycaemic control; however, whether underlying differences in genetic make-up can influence blood glucose responses to these dietary fatty acids is unknown. We examined the impact of dietary oils varying in SFA/MUFA content on changes in blood glucose levels (primary outcome) and whether these changes were modified by variants in the stearoyl-CoA desaturase (SCD) gene (secondary outcome). Obese men and women participating in the randomised, crossover, isoenergetic, controlled-feeding Canola Oil Multicenter Intervention Trial II consumed three dietary oils for 6 weeks, with washout periods of ˜6 weeks between each treatment. Diets studied included a high SFA/low MUFA Control oil (36·6 % SFA/28·2 % MUFA), a conventional canola oil (6·2 % SFA/63·1 % MUFA) and a high-oleic acid canola oil (5·8 % SFA/74·7 % MUFA). No differences in fasting blood glucose were observed following the consumption of the dietary oils. However, when stratified by SCD genotypes, significant SNP-by-treatment interactions on blood glucose response were found with additive models for rs1502593 (P = 0·01), rs3071 (P = 0·02) and rs522951 (P = 0·03). The interaction for rs3071 remained significant (P = 0·005) when analysed with a recessive model, where individuals carrying the CC genotype showed an increase (0·14 (sem 0·09) mmol/l) in blood glucose levels with the Control oil diet, but reductions in blood glucose with both MUFA oil diets. Individuals carrying the AA and AC genotypes experienced reductions in blood glucose in response to all three oils. These findings identify a potential new target for personalised nutrition approaches aimed at improving glycaemic control.
Haematopoietic stem cell transplantation is an important and effective treatment strategy for many malignancies, marrow failure syndromes, and immunodeficiencies in children, adolescents, and young adults. Despite advances in supportive care, patients undergoing transplant are at increased risk to develop cardiovascular co-morbidities.
Methods:
This study was performed as a feasibility study of a rapid cardiac MRI protocol to substitute for echocardiography in the assessment of left ventricular size and function, pericardial effusion, and right ventricular hypertension.
Results:
A total of 13 patients were enrolled for the study (age 17.5 ± 7.7 years, 77% male, 77% white). Mean study time was 13.2 ± 5.6 minutes for MRI and 18.8 ± 5.7 minutes for echocardiogram (p = 0.064). Correlation between left ventricular ejection fraction by MRI and echocardiogram was good (ICC 0.76; 95% CI 0.47, 0.92). None of the patients had documented right ventricular hypertension. Patients were given a survey regarding their experiences, with the majority both perceiving that the echocardiogram took longer (7/13) and indicating they would prefer the MRI if given a choice (10/13).
Conclusion:
A rapid cardiac MRI protocol was shown feasible to substitute for echocardiogram in the assessment of key factors prior to or in follow-up after haematopoietic stem cell transplantation.
Traits of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are strongly associated in children and adolescents, largely due to genetic factors. Less is known about the phenotypic and aetiological overlap between ADHD and ASD traits in adults.
Methods
We studied 6866 individuals aged 20–28 years from the Swedish Study of Young Adult Twins. Inattention (IA) and hyperactivity/impulsivity (HI) were assessed using the WHO Adult ADHD Self-Report Scale-V1.1. Repetitive and restricted behaviours (RRB) and social interaction and communication (SIC) were assessed using the Autism-Tics, ADHD, and other Comorbidities inventory. We used structural equation modelling to decompose covariance between these ADHD and ASD trait dimensions into genetic and shared/non-shared environmental components.
Results
At the phenotypic level, IA was similarly correlated with RRB (r = 0.33; 95% Confidence Interval (CI) 0.31–0.36) and with SIC (r = 0.32; 95% CI 0.29–0.34), whereas HI was more strongly associated with RRB (r = 0.38; 95% CI 0.35–0.40) than with SIC (r = 0.24; 95% CI 0.21–0.26). Genetic and non-shared environmental effects accounted for similar proportions of the phenotypic correlations, whereas shared environmental effects were of minimal importance. The highest genetic correlation was between HI and RRB (r = 0.56; 95% 0.46–0.65), and the lowest was between HI and SIC (r = 0.33; 95% CI 0.23–0.43).
Conclusions
We found evidence for dimension-specific phenotypic and aetiological overlap between ADHD and ASD traits in adults. Future studies investigating mechanisms underlying comorbidity between ADHD and ASD may benefit from exploring several symptom-dimensions, rather than considering only broad diagnostic categories.
Sexual dysfunction is common in psychotic disorder but it is not clear whether it is intrinsic to the development of the illness or secondary to other factors.
Aims
To compare sexual function in people at ultra-high risk (UHR) of a psychotic disorder, patients with first-episode psychosis predominantly taking antipsychotic drugs and healthy volunteers.
Method
Sexual function was assessed in a UHR group (n = 31), a group with first-episode psychosis (n = 37) and a matched control group of healthy volunteers (n = 56) using the Sexual Function Questionnaire.
Results
There was a significant effect of group on sexual function(P<0.001). Sexual dysfunction was evident in 50% of the UHR group, 65% of first-episode patients and 21% of controls. Within the UHR group, sexual dysfunction was more marked in those who subsequently developed psychosis than in those who did not. Across all groups the severity of sexual dysfunction was correlated with the severity of psychotic symptoms (P<0.001). Within the first-episode group there was no significant difference in sexual dysfunction between patients taking prolactin-raising v. prolactin-sparing antipsychotics.
Conclusions
Sexual dysfunction is present prior to onset of psychosis, suggesting it is intrinsic to the development of illness unlikely to be related to the prolactin-raising properties of antipsychotic medication.
This book traces the origins and early development of what are today loosely termed Britain's Overseas Information Services. It examines how, at the end of the First World War, the British government came to forfeit the considerable lead it had established in propaganda since 1914, and the reasons why it had gradually to re-enter the field during the inter-war years as a direct response to totalitarianism. It surveys the pioneering work of the Foreign Office News Department and its important press office, the commercial propaganda conducted by the Empire Marketing Board and the Travel Association, the foundation and rapid peacetime growth of the British Council to conduct 'cultural diplomacy', and the beginning of the BBC's World Service with the inauguration of foreign-language broadcasts in 1938.
Division X provides a common theme for astronomers using radio techniques to study a vast range of phenomena in the Universe, from exploring the Earth's ionosphere or making radar measurements in the Solar System, via mapping the distribution of gas and molecules in our own Galaxy and in other galaxies, to study the vast explosive processes in radio galaxies and QSOs and the faint afterglow of the Big Bang itself.
There have been important advances in radio astronomy in the last three years. New discoveries both at the galactic and extragalactic scale have been reported over this period and we highlight here several of them. The outstanding results of the Wilkinson Microwave Anisotropy Probe satellite, allowing an accurate determination of the main cosmological constants, are certainly among the most important. At the international level, the consolidation of the Atacama Large Millimeter Array project, with participation of the USA, Europe, and Japan and an estimated cost of around one billion US dollars, takes the construction of radio telescopes to a new level of complexity and potential. We also include the Progress Report of the Working Group on Historic Radio Astronomy, that includes a description of the duties and activities of this recently created working group.
In 1914 Britain had entered the First World War almost completely unprepared for the conduct of propaganda in foreign countries. That this was not the case on the outbreak of the Second World War was largely because of developments which occurred between 1935 and 1939.
The rapid growth of the peacetime machinery during this quinquennium, from the foundation of the British Council to the creation of the Industrial Publicity Unit, has already been discussed. These organisations were, however, designed to promote Britain's prestige in a peaceful, albeit troubled, world. It did not automatically follow that they would be called upon to undertake British overseas propaganda in time of war, when an entirely different set of conditions would require different solutions. Moreover, from an organisational point of view, one of the chief lessons to be drawn from the experience of the Great War was that if inter-departmental rivalry, overlapping and inefficiency were to be avoided in any future conflict, it would be advisable to centralise the conduct of all official propaganda under one roof. As the very appointment of the Vansittart Co-ordinating Committee in 1938 revealed, the record of the peacetime agencies was not a good one in this respect. Parallel to, but quite distinct from, the expansion of the peacetime apparatus, a sub-committee of the Committee of Imperial Defence was secretly working out the details for the establishment of a Ministry of Information to take charge of all propaganda – both at home and abroad – in the event of war.
Early in 1938 British overseas propaganda was about to enter a critical phase of its development. The advancements made in the direction of national projection during the previous three years had undeniably been impressive, but despite the progress now being made by the British Council with the energetic Lord Lloyd at its helm, despite governmental approval for the inauguration of a foreign-language service by the BBC and despite the investigations of the reconstituted Kingsley Wood committee into the deficiencies which still existed in the distribution of British news abroad, there nonetheless remained much work to be done in the cause of psychological rearmament. Hitherto the tendency had been to tackle each individual part of the propaganda problem separately. The Travel Association had been set up to conduct tourist and trade propaganda and the British Council for cultural propaganda, and the BBC had agreed to broadcast news in foreign languages on behalf of the government. In this somewhat spasmodic manner, the official British machinery for conducting propaganda overseas had been gradually built up. It was, perhaps, the only way that progress in this direction could have been made in the face of at times overwhelming opposition from the more traditionally minded elements in Whitehall who could not – or would not – accept the need for such work. Yet there still remained an urgent need to approach the subject in its entirety.
Although the exact nature of the contribution made by British propaganda towards the achievement of victory in 1918 must necessarily remain the subject of historical debate, the value of propaganda as an effective instrument of warfare was nonetheless widely appreciated by contemporaries. Regardless of whether the reputation for success either in helping to attract the United States into the war on the Allied side or in bringing the Central Powers to their knees is an undeserved myth or an undervalued reality, the fact remains that many people believed (or chose to believe) that these decisive events were not unrelated to the British government's skilful employment of propaganda between 1914 and 1918. There was, after all, much profit to be made from praising the work of Wellington House or that of Crewe House. In the United States, for example, the belief that the American people had somehow been duped into involvement in 1917 by propaganda merely served to reinforce the arguments of those isolationists who advocated withdrawal from the devious machinations of the Old World. And in Germany, the testimonies of prominent enemy personalities such as Hindenburg and Ludendorff (‘we were hypnotised by the enemy propaganda as a rabbit by a snake’) were seized upon by Adolf Hitler to perpetuate the legend that the German army had not been defeated on the field of battle but had been betrayed from within following the collapse of morale at home caused by Lord Northcliffe's propaganda from Crewe House. Northcliffe was himself more modest about his achievement, being content merely to claim: ‘We have to some extent hastened the end.’
The British propaganda experiment had certainly proved an impressive lesson in improvisation.
This book is a pioneering study of a little-known aspect of British foreign policy between the wars. Essentially, it is an examination of the peacetime origins and early development of what are today loosely termed Britain's Overseas Information Services. Accordingly, the book traces the work of the Foreign Office News Department and its important press office, the commercial propaganda conducted by such organisations as the Empire Marketing Board, the Travel Association and the Industrial Publicity Unit, the foundation and rapid expansion of the British Council, and the origins of the bbc's World and External services. It is not, however, designed to provide a definitive history of Britain's world-wide propaganda activities during the twenty years of peace that followed the First World War. Nor does this book aspire to be comprehensive in its treatment of the issues it does examine. Rather, it is intended to be a preliminary investigation into those official and semi-official organisations which were established to ‘project’ Britain abroad, the reasons for their creation, and the peculiar features which characterised such work.
Despite considerable scholarly interest in this subject during the inter-war period itself, historians, at least in the United Kingdom, have only recently begun to appreciate the importance of studying propaganda and its impact upon public opinion as part of our understanding of the twentieth century. There is still a long way to go before the subject earns the credibility its significance deserves. Few textbooks or general historical surveys dealing with the period devote more than a brief mention to the British government's activities in this direction, and even then it is usually in the context of the First and Second World Wars.