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Characterisation of age and polarity at onset in bipolar disorder
Janos L. Kalman, Loes M. Olde Loohuis, Annabel Vreeker, Andrew McQuillin, Eli A. Stahl, Douglas Ruderfer, Maria Grigoroiu-Serbanescu, Georgia Panagiotaropoulou, Stephan Ripke, Tim B. Bigdeli, Frederike Stein, Tina Meller, Susanne Meinert, Helena Pelin, Fabian Streit, Sergi Papiol, Mark J. Adams, Rolf Adolfsson, Kristina Adorjan, Ingrid Agartz, Sofie R. Aminoff, Heike Anderson-Schmidt, Ole A. Andreassen, Raffaella Ardau, Jean-Michel Aubry, Ceylan Balaban, Nicholas Bass, Bernhard T. Baune, Frank Bellivier, Antoni Benabarre, Susanne Bengesser, Wade H Berrettini, Marco P. Boks, Evelyn J. Bromet, Katharina Brosch, Monika Budde, William Byerley, Pablo Cervantes, Catina Chillotti, Sven Cichon, Scott R. Clark, Ashley L. Comes, Aiden Corvin, William Coryell, Nick Craddock, David W. Craig, Paul E. Croarkin, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Udo Dannlowski, Franziska Degenhardt, Maria Del Zompo, J. Raymond DePaulo, Srdjan Djurovic, Howard J. Edenberg, Mariam Al Eissa, Torbjørn Elvsåshagen, Bruno Etain, Ayman H. Fanous, Frederike Fellendorf, Alessia Fiorentino, Andreas J. Forstner, Mark A. Frye, Janice M. Fullerton, Katrin Gade, Julie Garnham, Elliot Gershon, Michael Gill, Fernando S. Goes, Katherine Gordon-Smith, Paul Grof, Jose Guzman-Parra, Tim Hahn, Roland Hasler, Maria Heilbronner, Urs Heilbronner, Stephane Jamain, Esther Jimenez, Ian Jones, Lisa Jones, Lina Jonsson, Rene S. Kahn, John R. Kelsoe, James L. Kennedy, Tilo Kircher, George Kirov, Sarah Kittel-Schneider, Farah Klöhn-Saghatolislam, James A. Knowles, Thorsten M. Kranz, Trine Vik Lagerberg, Mikael Landen, William B. Lawson, Marion Leboyer, Qingqin S. Li, Mario Maj, Dolores Malaspina, Mirko Manchia, Fermin Mayoral, Susan L. McElroy, Melvin G. McInnis, Andrew M. McIntosh, Helena Medeiros, Ingrid Melle, Vihra Milanova, Philip B. Mitchell, Palmiero Monteleone, Alessio Maria Monteleone, Markus M. Nöthen, Tomas Novak, John I. Nurnberger, Niamh O'Brien, Kevin S. O'Connell, Claire O'Donovan, Michael C. O'Donovan, Nils Opel, Abigail Ortiz, Michael J. Owen, Erik Pålsson, Carlos Pato, Michele T. Pato, Joanna Pawlak, Julia-Katharina Pfarr, Claudia Pisanu, James B. Potash, Mark H Rapaport, Daniela Reich-Erkelenz, Andreas Reif, Eva Reininghaus, Jonathan Repple, Hélène Richard-Lepouriel, Marcella Rietschel, Kai Ringwald, Gloria Roberts, Guy Rouleau, Sabrina Schaupp, William A Scheftner, Simon Schmitt, Peter R. Schofield, K. Oliver Schubert, Eva C. Schulte, Barbara Schweizer, Fanny Senner, Giovanni Severino, Sally Sharp, Claire Slaney, Olav B. Smeland, Janet L. Sobell, Alessio Squassina, Pavla Stopkova, John Strauss, Alfonso Tortorella, Gustavo Turecki, Joanna Twarowska-Hauser, Marin Veldic, Eduard Vieta, John B. Vincent, Wei Xu, Clement C. Zai, Peter P. Zandi, Psychiatric Genomics Consortium (PGC) Bipolar Disorder Working Group, International Consortium on Lithium Genetics (ConLiGen), Colombia-US Cross Disorder Collaboration in Psychiatric Genetics, Arianna Di Florio, Jordan W. Smoller, Joanna M. Biernacka, Francis J. McMahon, Martin Alda, Bertram Müller-Myhsok, Nikolaos Koutsouleris, Peter Falkai, Nelson B. Freimer, Till F.M. Andlauer, Thomas G. Schulze, Roel A. Ophoff
Journal:

The British Journal of Psychiatry / Volume 219 / Issue 6 / December 2021

Published online by Cambridge University Press:

25 August 2021, pp. 659-669

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December 2021
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Background
Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools.
Aims
To examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics.
Method
Genome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts.
Results
Earlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (β = −0.34 years, s.e. = 0.08), major depression (β = −0.34 years, s.e. = 0.08), schizophrenia (β = −0.39 years, s.e. = 0.08), and educational attainment (β = −0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO.
Conclusions
AAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.

Citizenship as Foundation of Rights

Meaning for America
Richard Sobel
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03 November 2016

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26 October 2016
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Citizenship as Foundation of Rights explores the nature and meaning of American citizenship and the rights flowing from citizenship in the context of current debates around politics, including immigration. The book explains the sources of citizenship rights in the Constitution and focuses on three key citizenship rights - the right to vote, the right to employment, and the right to travel in the US. It explains why those rights are fundamental and how national identification systems and ID requirements to vote, work and travel undermine the fundamental citizen rights. Richard Sobel analyzes how protecting citizens' rights preserves them for future generations of citizens and aspiring citizens here. No other book offers such a clarification of fundamental citizen rights and explains how ID schemes contradict and undermine the constitutional rights of American citizenship.

Notes
Richard Sobel, Northwestern University, Illinois
Book:

Citizenship as Foundation of Rights

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03 November 2016

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26 October 2016, pp 162-192
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4 - The Right to Employment
Richard Sobel, Northwestern University, Illinois
Book:

Citizenship as Foundation of Rights

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03 November 2016

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26 October 2016, pp 58-71
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Dedication
Richard Sobel, Northwestern University, Illinois
Book:

Citizenship as Foundation of Rights

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03 November 2016

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26 October 2016, pp v-vi
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6 - Threats to Citizenship Rights in Identification Regimes
Richard Sobel, Northwestern University, Illinois
Book:

Citizenship as Foundation of Rights

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03 November 2016

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26 October 2016, pp 109-130
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Bibliography
Richard Sobel, Northwestern University, Illinois
Book:

Citizenship as Foundation of Rights

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03 November 2016

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26 October 2016, pp 193-216
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Index
Richard Sobel, Northwestern University, Illinois
Book:

Citizenship as Foundation of Rights

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03 November 2016

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26 October 2016, pp 223-229
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2 - The Nature of American Citizenship as the Foundation of Rights
Richard Sobel, Northwestern University, Illinois
Book:

Citizenship as Foundation of Rights

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03 November 2016

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26 October 2016, pp 15-37
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7 - Other Countries’ Systems Constitute Warnings
Richard Sobel, Northwestern University, Illinois
Book:

Citizenship as Foundation of Rights

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03 November 2016

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26 October 2016, pp 131-150
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1 - Introduction
Richard Sobel, Northwestern University, Illinois
Book:

Citizenship as Foundation of Rights

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03 November 2016

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26 October 2016, pp 1-14
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3 - The Right to Vote
Richard Sobel, Northwestern University, Illinois
Book:

Citizenship as Foundation of Rights

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03 November 2016

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26 October 2016, pp 38-57
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References for Court Cases
Richard Sobel, Northwestern University, Illinois
Book:

Citizenship as Foundation of Rights

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03 November 2016

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26 October 2016, pp 218-222
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5 - The Right to Travel
Richard Sobel, Northwestern University, Illinois
Book:

Citizenship as Foundation of Rights

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03 November 2016

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26 October 2016, pp 72-108
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8 - Conclusions: Sustaining Empowering Citizenship
Richard Sobel, Northwestern University, Illinois
Book:

Citizenship as Foundation of Rights

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03 November 2016

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26 October 2016, pp 151-161
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Preface and Acknowledgments
Richard Sobel, Northwestern University, Illinois
Book:

Citizenship as Foundation of Rights

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03 November 2016

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26 October 2016, pp xi-xiv
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Contents
Richard Sobel, Northwestern University, Illinois
Book:

Citizenship as Foundation of Rights

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03 November 2016

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26 October 2016, pp vii-viii
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References for Briefs
Richard Sobel, Northwestern University, Illinois
Book:

Citizenship as Foundation of Rights

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03 November 2016

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26 October 2016, pp 217-218
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Copyright page
Richard Sobel, Northwestern University, Illinois
Book:

Citizenship as Foundation of Rights

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03 November 2016

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26 October 2016, pp iv-iv
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Voter-ID Laws Discourage Participation, Particularlyamong Minorities, and Trigger a Constitutional Remedy in LostRepresentation
Richard Sobel, Robert Ellis Smith
Journal:

PS: Political Science & Politics / Volume 42 / Issue 1 / January 2009

Published online by Cambridge University Press:

08 January 2009, pp. 107-110

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January 2009
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Because voter-identification laws discourage voter turnout,particularly among identifiable minority groups, theirimplementation abridges a fundamental constitutional right. The U.S.Constitution includes a little-known remedy for denying or abridgingthe right to vote that reduces a state's congressionalrepresentation in proportion to the extent of the abridgements.

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Characterisation of age and polarity at onset in bipolar disorder

Citizenship as Foundation of Rights

Notes

4 - The Right to Employment

Dedication

6 - Threats to Citizenship Rights in Identification Regimes

Bibliography

Index

2 - The Nature of American Citizenship as the Foundation of Rights

7 - Other Countries’ Systems Constitute Warnings

1 - Introduction

3 - The Right to Vote

References for Court Cases

5 - The Right to Travel

8 - Conclusions: Sustaining Empowering Citizenship

Preface and Acknowledgments

Contents

References for Briefs

Copyright page

Voter-ID Laws Discourage Participation, Particularlyamong Minorities, and Trigger a Constitutional Remedy in LostRepresentation

Search Results

Refine search

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26 results

Citizenship as Foundation of Rights