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In this prospective cohort of 1,012 Swiss hospital employees, 3 different assays were used to screen serum for SARS-CoV-2 antibodies. Seropositivity was 1%; the positive predictive values of the lateral-flow immunoassay were 64% (IgG) and 13% (IgM). History of fever and myalgia most effectively differentiated seropositive and seronegative participants.
In the treatment of panic disorder with agoraphobia, the efficacy of pharmacological, psychological and combined treatments has been established. Unanswered questions concern the relative efficacy of such treatments.
Aims
To demonstrate that moclobemide and cognitive–behavioural therapy (CBT) are effective singly and more effective in combination.
Method
Fifty-five patients were randomly assigned to an eight-week treatment of: moclobemide plus CBT; moclobemide plus clinical management (‘psychological placebo’); placebo plus CBT; or placebo plus clinical management.
Results
Comparisons between treatments revealed strong effects for CBT. Moclobemide with clinical management was not superior to placebo. The combination of moclobemide with CBT did not yield significantly better short-term results than CBT with placebo. The CBT results remained stable during a six-month follow-up, although a substantial proportion of patients treated with placebo plus CBT needed additional treatment.
Conclusions
CBT was highly effective in the treatment of panic disorder with agoraphobia and reduced agoraphobia to levels that were comparable to those of non-clinical controls.
We study a fluid flow queueing system with m independent sources alternating between periods of silence and activity; m ≥ 2. The distribution function of the activity periods of one source, is supposed to be intermediate regular varying. We show that the distribution of the net increment of the buffer during an aggregate activity period (i.e. when at least one source is active) is asymptotically tail-equivalent to the distribution of the net input during a single activity period with intermediate regular varying distribution function. In this way, we arrive at an asymptotic representation of the Palm-stationary tail-function of the buffer content at the beginning of aggregate activity periods. Our approach is probabilistic and extends recent results of Boxma (1996; 1997) who considered the special case of regular variation.
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