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This interdisciplinary collection explores how a human rights perspective offers new insights and tools into the current obstacles to education. It examines the role of private actors, the need to hold states to account, the balance between religion, culture and education, girls’ right to education and the role of courts.
The goal of disaster triage at both the prehospital and in-hospital level is to maximize resources and optimize patient outcomes. Of the disaster-specific triage methods developed to guide health care providers, the Simple Triage and Rapid Treatment (START) algorithm has become the most popular system world-wide. Despite its appeal and global application, the accuracy and effectiveness of the START protocol is not well-known.
Objectives:
The purpose of this meta-analysis was two-fold: (1) to estimate overall accuracy, under-triage, and over-triage of the START method when used by providers across a variety of backgrounds; and (2) to obtain specific accuracy for each of the four START categories: red, yellow, green, and black.
Methods:
A systematic review and meta-analysis was conducted that searched Medline (OVID), Embase (OVID), Global Health (OVID), CINAHL (EBSCO), Compendex (Engineering Village), SCOPUS, ProQuest Dissertations and Theses Global, Cochrane Library, and PROSPERO. The results were expanded by hand searching of journals, reference lists, and the grey literature. The search was executed in March 2020. The review considered the participants, interventions, context, and outcome (PICO) framework and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Accuracy outcomes are presented as means with 95% confidence intervals (CI) as calculated using the binomial method. Pooled meta-analyses of accuracy outcomes using fixed and random effects models were calculated and the heterogeneity was assessed using the Q statistic.
Results:
Thirty-two studies were included in the review, most of which utilized a non-randomized study design (84%). Proportion of victims correctly triaged using START ranged from 0.27 to 0.99 with an overall triage accuracy of 0.73 (95% CI, 0.67 to 0.78). Proportion of over-triage was 0.14 (95% CI, 0.11 to 0.17) while the proportion of under-triage was 0.10 (95% CI, 0.072 to 0.14). There was significant heterogeneity of the studies for all outcomes (P < .0001).
Conclusion:
This meta-analysis suggests that START is not accurate enough to serve as a reliable disaster triage tool. Although the accuracy of START may be similar to other models of disaster triage, development of a more accurate triage method should be urgently pursued.
Psychosocial factors may influence mortality and morbidity after coronary bypass surgery (CABG), but it is unclear when, post-surgery, they best predict the outcome, if they interact, or whether results differ for men and women.
Methods
This prospective, observational study assessed depression symptoms, social support, marital status, household responsibility, functional impairment, mortality and need for further coronary procedures over 14 years of follow-up. Data were collected in-hospital post-CABG and at home 1-year later. Mortality and subsequent cardiac procedure data were extracted from a Cardiac Registry.
Results
Of 296 baseline participants, 78% (43% were women) completed data at 1-year post-CABG. Long-term survival was shorter with 1-year depression and lower household responsibility but that was not true for the measures taken at baseline [HR for depression = 1.27; 95% CI 1.02–1.59 v. 0.99 (0.78–1.25), and HR = 0.71; 95% CI 0.52–0.97 v. 0.97 (0.80–1.16)] for household responsibility. An interaction between depression symptoms and social support at year 1 [χ2 (11) = 111.05, p < 0.001] revealed a greater hazard of mortality d with increased depression only at mean (HR = 1.67; 95% CI 1.21–2.26) and high social support (HR = 2.23; 95% CI 1.46–3.40). Depression also accounted for increased event recurrence. There were no significant interactions of sex with medical long-term outcomes.
Conclusions
In a sex-balanced sample, depression and household responsibility measured at 1-year post-CABG were associated with significant variance in unadjusted and adjusted predictor models of long-term mortality whereas the same indices determined right after the procedure were not significant predictors.
Background: The capacity to monitor the emergence of carbapenemase-producing organisms (CPO) is critical in limiting transmission. CPO-colonized patients can be identified by screening rectal specimens for carbapenemase genes and the Cepheid GeneXpert Carba-R (XCR), the only FDA-approved test, is limited to 5 carbapenemase genes and cannot identify the bacterial species. Objective: We describe the development and validation of culture-based methods for the detection of CPO in rectal cultures (RCs) and nonrectal cultures (NRCs) of tracheal aspirate and axilla-groin swabs. Methods: Colonization screening was performed at 3 US healthcare facilities; specimens of RC swabs and NRC ESwabs were collected. Each specimen was inoculated to a MacConkey broth enrichment tube for overnight incubation then were subcultured to MacConkey agar with meropenem and ertapenem 10 µg disks (BEMA) and CHROMagar KPC (KCHR) or CHROMagar Acinetobacter (ACHR). All media were evaluated for the presence of carbapenem-resistant organisms; suspect colonies were screened by real-time PCR for the most common carbapenemase genes. MALDI-TOF was performed for species identification. BEMA, a previously validated method, was the comparator for 52 RCs; clinical culture (CC) served as the comparator method for 66 NRCs. Select CPO-positive and -negative specimens underwent reproducibility testing. Results: Among 56 patients undergoing colonization screening, 12 (21%) carried a CPO. Only 1 patient had CPO solely from RC. Also, 6 patients had both CPO-positive RC and NRC, and 5 patients only had a CPO-positive NRC. Of the latter, 4 had a CPO-positive tracheal specimen, and 1 had a positive culture from both tracheal and axilla-groin specimens. Sensitivity of BEMA (70%) for NRC was lower than for KCHR (96%) and ACHR (88 %) for all specimens. All methods showed a specificity of 100% and reproducibility of 92%. The detected CPO included OXA-23–positive Acinetobacter baumannii, NDM-positive Escherichia coli, KPC-positive Pseudomonas aeruginosa and 4 genera of KPC-positive Enterobacteriaceae. Conclusions:The addition of nonrectal specimens and use of selective media contributed to increased sensitivity and enhanced identification of CPO-colonized patients. Positive cultures were equally distributed among the 3 specimen types. The addition of the nonrectal specimens resulted in the identification of more colonized patients. The culture-based method was successful in detecting an array of different CPOs and target genes, including genes not detected by the Carba-R assay (eg, blaOXA-23-like). Enhanced isolation and characterization of CPOs will be key in aiding epidemiologic investigations and strengthening targeted guidance for containment strategies.
Funding: None
Disclosures: We discuss the drug combination aztreonam-avibactam and acknowledge that this drug combination is not currently FDA approved.
People aging with long-term physical disabilities (PAwLTPD), meaning individuals with onset of disability from birth through midlife, often require long-term support services (LTSS) to remain independence. The LTSS system is fragmented into aging and disability organizations with little communication between them. In addition, there are currently no evidence-based LTSS-type programs listed on the Administration for Community Living website that have been demonstrated to be effective for PAwLTPD. Because of these gaps, we have developed a community-based research network (CBRN), drawing on the practice-based research network model (PBRN), to bring together aging and disability organizations to address the lack of evidence-based programs for PAwLTPD.
Materials and Methods:
Community-based organizations serving PAwLTPD across the state of Missouri were recruited to join the CBRN. A formative process evaluation of the network was conducted after a year to evaluate the effectiveness of the network.
Results:
Nine community-based organizations across the state of Missouri joined the CBRN. CBRN members include three centers for independent living (CILs), three area agencies on aging (AAAs), one CIL/AAA hybrid, one non-CIL disability organization, and one non-AAA aging organization. To date, we have held seven meetings, provided educational opportunities for CBRN members, and launched an inaugural research study within the CBRN. Formative evaluation data indicate that CBRN members feel that participation in the CBRN is beneficial.
Conclusion:
The PBRN model appears to be a feasible framework for use with community-based organizations to facilitate communication between agencies and to support research aimed at addressing the needs of PAwLTPD.
To investigate the prevalence of folic acid deficiency in Queensland-wide data of routine laboratory measurements, especially in high-risk sub-populations.
Design:
Secondary health data analysis.
Setting:
Analysis of routine folic acid tests conducted by Pathology Queensland (AUSLAB).
Participants:
Female and male persons aged 0–117 years with routine folic acid testing between 1 January 2004 and 31 December 2015. If repeat tests on the same person were conducted, only the initial test was analysed (n 291 908).
Results:
Overall the prevalence of folic acid deficiency declined from 7·5 % before (2004–2008) to 1·1 % after mandatory folic acid fortification (2010–2015; P < 0·001) reflecting a relative reduction of 85 %. Levels of erythrocyte folate increased significantly from a median (interquartile range) of 820 (580–1180) nmol/l in 2008 before fortification to 1020 (780–1350) nmol/l in 2010 (P < 0·001) after fortification. The prevalence of folic acid deficiency in the Indigenous population (14 792 samples) declined by 93 % (17·4 v. 1·3 %; P < 0·001); and by 84 % in non-Indigenous residents (7·0 v. 1·1 %; P < 0·001). In a logistic regression model the observed decrease of folic acid deficiency between 2008 and 2010 was found independent of gender, age and ethnicity (ORcrude = 0·20; 95 % CI 0·18, 0·23; P < 0·001; ORadjusted = 0·21; 95 % CI 0·18, 0·23; P < 0·001).
Conclusions:
While voluntary folic acid fortification, introduced in 1995, failed especially in high-risk subgroups, the 2009 mandatory folic acid fortification programme coincided with a substantial decrease of folic acid deficiency in the entire population.
Edited by
Sandra Fredman, University of Oxford Faculty of Law,Meghan Campbell, New College, University of Oxford,Helen Taylor, Balliol College, University of Oxford
Edited by
Sandra Fredman, University of Oxford Faculty of Law,Meghan Campbell, New College, University of Oxford,Helen Taylor, Balliol College, University of Oxford
Edited by
Sandra Fredman, University of Oxford Faculty of Law,Meghan Campbell, New College, University of Oxford,Helen Taylor, Balliol College, University of Oxford
Education is at the heart of the global struggle to alleviate poverty and reduce inequality. It has been demonstrated that one extra year of education is associated with a reduction in inequality (as measured by the Gini coefficient) of 1.4 percentage points. Yet it is precisely the most disadvantaged who face the greatest obstacles to accessing quality education. Although some progress has been made in recent decades, there were still as many as 57 million out-of-school children of primary school age in 2015. Many of these will never access education. What role, then, can human rights play in addressing these issues? Education has been recognised as a fundamental human right at least since 1948, when the Universal Declaration of Human Rights declared that everyone has the right to free and compulsory education. Importantly, the right extends beyond access to education. It also includes quality education. Education must be ‘directed to the full development of the human personality’ and ‘promote understanding, tolerance and friendship among all nations, racial or religious groups’. The right to education has also been recognised in the major international human rights instruments, and in the domestic law of numerous countries.
This volume asks what role human rights can play in addressing some of the most challenging issues in the quest for quality education for all. We provide case studies from both the global South and the global North. The challenges are surprisingly similar, despite marked differences in development. From the South, we focus on India, Kenya and South Africa. Both countries face an enormous chasm between the ideal of equal rights to quality education and the reality; each has relatively recently given entrenched constitutional status to the right to education; and both have seen human rights litigation play an important part. From the global North, we look at New York State, where educational disadvantage, in the midst of the richest country in the world, is even more striking. Although there is no constitutional right to education at federal level, the right is entrenched in the New York State constitution, and human rights litigation has been utilised in the quest for a better quality of education for disadvantaged innercity children.
Edited by
Sandra Fredman, University of Oxford Faculty of Law,Meghan Campbell, New College, University of Oxford,Helen Taylor, Balliol College, University of Oxford
Edited by
Sandra Fredman, University of Oxford Faculty of Law,Meghan Campbell, New College, University of Oxford,Helen Taylor, Balliol College, University of Oxford
Edited by
Sandra Fredman, University of Oxford Faculty of Law,Meghan Campbell, New College, University of Oxford,Helen Taylor, Balliol College, University of Oxford
This collection of essays has explored a range of challenges faced by minorities and disadvantaged groups in education. The book demonstrates how a human rights-based approach brings these challenges into sharper focus and offers a framework for addressing them so that we can achieve quality education for all. These insights are enriched through the comparative perspective provided by the range of jurisdictions featured in the collection. Such a perspective highlights the complexity of the challenges faced and presents contextualised responses to them. Human rights provide a common language to share and compare the experiences of minorities and disadvantaged groups in education. While requiring sensitive attention to be given to how these experiences are embedded in particular contexts, a comparative perspective also enables resonances to be felt across contextual divides. It is therefore capable of inspiring new ideas for overcoming long-standing challenges in education.
An increasingly pressing challenge faced by a human rights-based approach, covered in Part I of this collection, is the question of how to hold actors other than the state accountable for providing quality education to all. While remaining open to the potential benefits of private educational initiatives for disadvantaged and marginalised children who might lose out in the public school system (Smuts), the accountability deficit associated with the involvement of private actors in education needs to be addressed. This accountability deficit leaves minorities and disadvantaged groups most at risk that their right to education will not be realised, and the challenge moving forward is to develop robust accountability mechanisms for ensuring both the state and private actors uphold children's rights to and in education (O’Mahony).
Part II emphasised the importance of sensitive balancing of competing rights and interests in education, particularly with respect to the tension that often arises between the right to education and the freedom of religion and culture. An especially important insight offered by both chapters in Part II is that this balancing exercise requires acute awareness of the contextual and historical positioning of minority groups within the education system. While a human rights-based approach calls for protections to be extended to minorities and disadvantaged groups to ensure they are not marginalised by the education system, we should remain alert to such protections being subverted by groups seeking minority status in order to exclude other groups (Kothari) or being abused in order to preserve historical privilege or restrict access to education (Bishop).
Edited by
Sandra Fredman, University of Oxford Faculty of Law,Meghan Campbell, New College, University of Oxford,Helen Taylor, Balliol College, University of Oxford
Edited by
Sandra Fredman, University of Oxford Faculty of Law,Meghan Campbell, New College, University of Oxford,Helen Taylor, Balliol College, University of Oxford
Edited by
Sandra Fredman, University of Oxford Faculty of Law,Meghan Campbell, New College, University of Oxford,Helen Taylor, Balliol College, University of Oxford
Edited by
Sandra Fredman, University of Oxford Faculty of Law,Meghan Campbell, New College, University of Oxford,Helen Taylor, Balliol College, University of Oxford
To understand enablers and barriers influencing postpartum screening for type 2 diabetes following gestational diabetes in Australian Indigenous women and how screening might be improved.
Background
Australian Indigenous women with gestational diabetes mellitus (GDM) are less likely than other Australian women to receive postpartum diabetes screening. This is despite a fourfold higher risk of developing type 2 diabetes within eight years postpartum.
Methods
We conducted interviews with seven Indigenous women with previous GDM, focus groups with 20 Indigenous health workers and workshops with 24 other health professionals. Data collection included brainstorming, visualisation, sorting and prioritising activities. Data were analysed thematically using the Theoretical Domains Framework. Barriers are presented under the headings of ‘capability’, ‘motivation’ and ‘opportunity’. Enabling strategies are presented under ‘intervention’ and ‘policy’ headings.
Findings
Participants generated 28 enabling environmental, educational and incentive interventions, and service provision, communication, guideline, persuasive and fiscal policies to address barriers to screening and improve postpartum support for women. The highest priorities included providing holistic social support, culturally appropriate resources, improving Indigenous workforce involvement and establishing structured follow-up systems. Understanding Indigenous women’s perspectives, developing strategies with health workers and action planning with other health professionals can generate context-relevant feasible strategies to improve postpartum care after GDM. Importantly, we need evidence which can demonstrate whether the strategies are effective.
It is generally agreed by most observers that the Millennium Development Goals (MDGs) have fallen short of achieving gender equality and women's empowerment. Today, women continue to be more likely than men to live in poverty, and more than 18 million girls in sub-Saharan Africa are out of school. One of the crucial reasons for the failure of the MDGs in relation to women was their inability to address the deeply entrenched and interlocking factors that perpetuate women's disadvantage. The new Sustainable Development Goals (SDGs), as articulated in the 2030 Agenda for Sustainable Development, constitute an improvement over the MDGs. Goal 5, which enshrines the stand-alone goal on gender equality, is comprised of nine specific targets, including the elimination of gender-based violence and access to reproductive health. In addition, gender equality is mainstreamed into numerous others goals. Given that the global community is now poised to implement the SDGs, the challenge is how best to integrate a transformative approach into the planning, implementation, and delivery of the specific targets so that the SDGs contribute to achieving gender equality and women's empowerment.
Clostridium difficile infection (CDI) is a common hospital-acquired infection. Previous reports on the incidence, risk factors, and impact of CDI on resources in the surgical population are limited. In this context, we study CDI across diverse surgical settings.
METHODS
We prospectively identified patients with laboratory-confirmed postoperative CDI after 40 different general, vascular, or gynecologic surgeries at 52 academic and community hospitals between July 2012 and September 2013. We used multivariable regression models to identify CDI risk factors and to determine the impact of CDI on resource utilization.
RESULTS
Of 35,363 patients, 179 (0.51%) developed postoperative CDI. The highest rates of CDI occurred after lower-extremity amputation (2.6%), followed by bowel resection or repair (0.9%) and gastric or esophageal operations (0.7%). Gynecologic and endocrine operations had the lowest rates (0.1% and 0%, respectively). By multivariable analyses, older age, chronic immunosuppression, hypoalbuminemia (≤3.5 g/dL), and preoperative sepsis were associated with CDI. Use of prophylactic antibiotics was not independently associated with CDI, neither was sex, body mass index (BMI), surgical priority, weight loss, or comorbid conditions. Three procedure groups had higher odds of postoperative CDI: lower-extremity amputations (adjusted odds ratio [aOR], 3.5; P=.03), gastric or esophageal operations (aOR, 2.1; P=.04), and bowel resection or repair (aOR, 2; P=.04). Postoperative CDI was independently associated with increased length of stay (mean, 13.7 d vs 4.5 d), emergency department presentations (18.9 vs 9.1%) and readmissions (38.9% vs 7.2%, all P<.001).
CONCLUSIONS
Incidence of postoperative CDI varies by surgical procedure. Postoperative CDI is also associated with higher rates of extended length of stay, emergency room presentations, and readmissions, which places a potentially preventable burden on hospital resources.