Recent changes to US research funding are having far-reaching consequences that imperil the integrity of science and the provision of care to vulnerable populations. Resisting these changes, the BJPsych Portfolio reaffirms its commitment to publishing mental science and advancing psychiatric knowledge that improves the mental health of one and all.

This editorial considers the value and nature of academic psychiatry by asking what defines the specialty and psychiatrists as academics. We frame academic psychiatry as a way of thinking that benefits clinical services and discuss how to inspire the next generation of academics.

In the USA, western Washington (WWA) and the Alaska (AK) Interior are two regions where maritime and continental climates, high latitude and cropping systems necessitate early maturing spring wheat (Triticum aestivum L.). Both regions aim to increase the production of hard spring bread wheat for human consumption to support regional agriculture and food systems. The Nordic region of Europe has a history of breeding for early maturing spring wheat and also experiences long daylengths with mixed maritime and continental climates. Nordic wheat also carries wildtype (wt) NAM-B1, an allele associated with accelerated senescence and increased grain protein and micronutrient content, at a higher frequency than global germplasm. Time to senescence, yield, protein and mineral content were evaluated on 42 accessions of Nordic hard red spring wheat containing wt NAM-B1 over 2 years on experimental stations in WWA and the AK Interior. Significant variation was found by location and accession for time to senescence, suggesting potential parental lines for breeding programmes targeting early maturity. Additionally, multiple regression analysis showed that decreased time to senescence correlated negatively with grain yield and positively with grain protein, iron and zinc content. Breeding for early maturity in these regions will need to account for this potential trade-off in yield. Nordic wt NAM-B1 accessions with early senescence yet with yields similar to regional checks are reported. Collaboration among alternative wheat regions can aid in germplasm exchange and varietal development as shown here for the early maturing trait.

“We, the nationals of a big nation, have almost always been guilty, in historic practice, of innumerable cases of violence; furthermore, we commit violence and insult innumerable times without noticing it.”

Minority language rights in Georgia, which are inseparable from economic, social and educational inequalities among the different ethnic groups, run along two axes: Georgian's relation to Russian and Georgian's relation with its own minority languages. Since the late 1980s, Moscow's diminishing power and the republic's internal fragmentation have shifted the emphasis from the first to the second. Newly independent Georgia, which is 70% Georgian, now confronts a problem familiar to many post-colonial states: what status should the multiplicity of languages in the republic have? Should Georgian be the only official language, and if so, in what contexts can non-Georgians use their native language? Such issues are part of larger questions about domination, entitlement and ethnic status, issues which have bedeviled the successive Georgian governments' attempts at state-building. In the last two years, language conflicts in Georgia have been overwhelmed by violent secessionist struggles, and the state language program which was perceived as vital to Georgia's future when it was adopted in August 1989, has become secondary today. But if the ethnically based wars are to end, language relations must be settled. As it stands, the language program is unlikely to help.

Most non-linear fluids for which the appropriate measurements have been made exhibit non-zero and unequal normal stress differences in shearing flows. Power-law models such as Glen’s law cannot represent this phenomenon. The simplest constitutive equation that does embody normal stress effects defines the second-order fluid. An exact analytical solution for biaxial creep of such a fluid is fit to data from four tests on polycrystalline ice. The model gives an excellent representation of both primary and secondary creep. The fits provide values for the three material constants. These coefficients indicate positive first and second normal stress differences. One consequence is the prediction that a steady open-channel flow will exhibit a longitudinal free-surface depression of up to several meters for sufficiently thick ice on steep slopes. In addition, the compressive principal stress at the channel margin is decreased and the tensile principal stress is increased in magnitude over those predicted by models without normal stresses. The normal stresses thus favor the formation of crevasses. Furthermore, the angle these crevasses form with the channel margin is decreased.

Direct stimulation of 23 median, 13 ulnar and 2 peroneal nerves at the time of surgical exploration has been used to locate, and characterize the conduction abnormalities in thenerves. The most frequent location of the major conduction abnormalities in the median nerve was in the first 1-2 cm distal to the origin of the carpal tunnel. In the ulnar nerve the important conduction abnormalities were located most frequently in the segments 1 cm proximal and distal to the medial epicondyle. In the peroneal nerve the major conduction abnormalities occurred proximal or distal to the entry point of the common peroneal nerve into the peroneus longusmuscle.

Nanomedicine is yielding new and improved treatments and diagnostics for a range of diseases and disorders. Nanomedicine applications incorporate materials and components with nanoscale dimensions (often defined as 1-100 nm, but sometimes defined to include dimensions up to 1000 nm, as discussed further below) where novel physiochemical properties emerge as a result of size-dependent phenomena and high surface-to-mass ratio. Nanotherapeutics and in vivo nanodiagnostics are a subset of nanomedicine products that enter the human body. These include drugs, biological products (biologics), implantable medical devices, and combination products that are designed to function in the body in ways unachievable at larger scales. Nanotherapeutics and in vivo nanodiagnostics incorporate materials that are engineered at the nanoscale to express novel properties that are medicinally useful. These nanomedicine applications can also contain nanomaterials that are biologically active, producing interactions that depend on biological triggers. Examples include nanoscale formulations of insoluble drugs to improve bioavailability and pharmacokinetics, drugs encapsulated in hollow nanoparticles with the ability to target and cross cellular and tissue membranes (including the bloodbrain barrier) and to release their payload at a specific time or location, imaging agents that demonstrate novel optical properties to aid in locating micrometastases, and antimicrobial and drug-eluting components or coatings of implantable medical devices such as stents.