During the half century before the Communist take-over of 1949, there occurred twice in China a large scale opposition to Christianity: the Boxer Uprising of 1900 and the anti-Christian movement of 1922–1927. Both these movements were crises of East-West contact, and Chinese reactions against foreign culture. They can be understood only in the context of the modern changes in Chinese culture and society. This study of the anti-Christian agitation of 1922–27 seeks to clarify the nature and constituent forces of this movement in the rapidly changing and complicated history of China in the 1920s.