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The Cambridge Handbook of Behavioural Data Science offers an essential exploration of how behavioural science and data science converge to study, predict, and explain human, algorithmic, and systemic behaviours. Bringing together scholars from psychology, economics, computer science, engineering, and philosophy, the Handbook presents interdisciplinary perspectives on emerging methods, ethical dilemmas, and real-world applications. Organised into modular parts-Human Behaviour, Algorithmic Behaviour, Systems and Culture, and Applications—it provides readers with a comprehensive, flexible map of the field. Covering topics from cognitive modelling to explainable AI, and from social network analysis to ethics of large language models, the Handbook reflects on both technical innovations and the societal impact of behavioural data, and reinforces concepts in online supplementary materials and videos. The book is an indispensable resource for researchers, students, practitioners, and policymakers who seek to engage critically and constructively with behavioural data in an increasingly digital and algorithmically mediated world.
Tenecteplase has been shown to be non-inferior to alteplase for the treatment of acute ischemic stroke within 4.5 hours of stroke onset. While not formally approved by regulatory authorities, many jurisdictions have transitioned to using tenecteplase for routine stroke treatment because it is simpler to use and has cost advantages.
Methods:
We report a three-phase time-series analysis over 2.5 years and the process for transition from use of alteplase to tenecteplase for the routine treatment of acute ischemic stroke from a system-wide perspective involving an entire province. The transition was planned and implemented centrally. Data were collected in clinical routine, arising from both administrative sources and a prospective stroke registry, and represent real-world outcome data. Data are reported using standard descriptive statistics.
Results:
A total of 1211 patients were treated with intravenous thrombolysis (477 pre-transition using alteplase, 180 transition period using both drugs, 554 post-transition using tenecteplase). Baseline characteristics, adverse events and outcomes were similar between epochs. There were four dosing errors with tenecteplase, including providing the cardiac dose to two patients. There were no instances of major hemorrhage associated with dosing errors.
Discussion:
The transition to using intravenous tenecteplase for stroke treatment was seamless and resulted in identical outcomes to intravenous alteplase.
The best prehospital transport strategy for patients with suspected stroke due to possible large vessel occlusion varies by jurisdiction and available resources. A foundational problem is the lack of a definitive diagnosis at the scene. Rural stroke presentations provide the most problematic triage destination decision-making. In Alberta, Canada, the implementation and 5-year experience with a rural field consultation approach to provide service to rural patients with acute stroke is described.
Methods:
The protocols established through the rural field consultation system and the subsequent transport patterns for suspected stroke patients during the first 5 years of implementation are presented. Outcomes are reported using home time and data are summarized using descriptive statistics.
Results:
From April 2017 to March 2022, 721 patients met the definition for a rural field consultation, and 601 patients were included in the analysis. Most patients (n = 541, 90%) were transported by ground ambulance. Intravenous thrombolysis was provided for 65 (10.8%) of patients, and 106 (17.6%) underwent endovascular thrombectomy. The median time from first medical contact to arterial access was 3.2 h (range 1.3–7.6) in the direct transfers, compared to 6.5 h (range 4.6–7.9) in patients arriving indirectly to the comprehensive stroke center (CSC). Only a small proportion of patients (n = 5, 0.8%) were routed suboptimally to a primary stroke center and then to a CSC where they underwent endovascular therapy.
Conclusions:
The rural field consultation system was associated with shortened delays to recanalization and demonstrated that it is feasible to improve access to acute stroke care for rural patients.
Syncope is common among pediatric patients and is rarely pathologic. The mechanisms for symptoms during exercise are less well understood than the resting mechanisms. Additionally, inert gas rebreathing analysis, a non-invasive examination of haemodynamics including cardiac output, has not previously been studied in youth with neurocardiogenic syncope.
Methods:
This was a retrospective (2017–2023), single-center cohort study in pediatric patients ≤ 21 years with prior peri-exertional syncope evaluated with echocardiography and cardiopulmonary exercise testing with inert gas rebreathing analysis performed on the same day. Patients with and without symptoms during or immediately following exercise were noted.
Results:
Of the 101 patients (15.2 ± 2.3 years; 31% male), there were 22 patients with symptoms during exercise testing or recovery. Resting echocardiography stroke volume correlated with resting (r = 0.53, p < 0.0001) and peak stroke volume (r = 0.32, p = 0.009) by inert gas rebreathing and with peak oxygen pulse (r = 0.61, p < 0.0001). Patients with syncopal symptoms peri-exercise had lower left ventricular end-diastolic volume (Z-score –1.2 ± 1.3 vs. –0.36 ± 1.3, p = 0.01) and end-systolic volume (Z-score –1.0 ± 1.4 vs. −0.1 ± 1.1, p = 0.001) by echocardiography, lower percent predicted peak oxygen pulse during exercise (95.5 ± 14.0 vs. 104.6 ± 18.5%, p = 0.04), and slower post-exercise heart rate recovery (31.0 ± 12.7 vs. 37.8 ± 13.2 bpm, p = 0.03).
Discussion:
Among youth with a history of peri-exertional syncope, those who become syncopal with exercise testing have lower left ventricular volumes at rest, decreased peak oxygen pulse, and slower heart rate recovery after exercise than those who remain asymptomatic. Peak oxygen pulse and resting stroke volume on inert gas rebreathing are associated with stroke volume on echocardiogram.
Understanding the processes that give rise to networks gives us a better grasp of why we see the networks we do, where we might expect to find them, and how we might expect them to change over time. One way to achieve this is to create simulated networks. Simulated networks allow us to build networks based on detailed principles. We can then ask how networks derived from these principles behave and, correspondingly, understand how our observed networks may be generated by similar principles. This chapter explores many generative algorithms, including random graphs, small world networks, preferential attachment and acquisition, fitness networks, configuration models, amongst many others.
For any form of communication to make it beyond the category of talking to oneself, at least two individuals must share a common lexicon. Before languages can evolve into more complex forms, there must first be a pragmatic sense in which one individual can communicate a basic idea to another. How might shared lexicons have originated? Standard explorations of language often look in well-connected social groups such as chimpanzees, frequently numbering in the tens of individuals. But we might ask if language perhaps didn’t begin in a more humble arrangement, involving social groups of just two or a few individuals, such as that found in the orangutan? Agent-based models combined with network science offer a way to study this problem. By treating nodes as agents with strict rule-based behavior and edges as opportunities for interaction, agent-based models provide frameworks for studying how behavior and connectivity interact to create emergent phenomenon, such as the evolution of cooperation and cultural change. Here we will explore an agent-based model of the naming game to address how structure influences the emergence of shared lexicons.
What is memory? Scientists have proposed a wide variety of spatial metaphors to understand it. These range from the 2D wax tablets proposed by Plato and Aristotle and subsequently Freud, with his magic writing pad, to the 3D physical spaces that one can walk around inside, such as the subway of Collins and Quillian. If memory has such a spatial structure, then it suggests a simple rule: items in memory can be near or far from one another. Anything with a near-and-far structure lends itself to a network representation. Such spatial structure also lends itself to being in the wrong place at the wrong time: remembering things that never happened and forgetting things that did. This chapter explores how structure facilitates memories and also looks at a specific case of false memory to highlight how modeling the process of spreading activation on networks can enrich our understanding of structure beyond degree.
The false consensus effect is the observation that people tend to overestimate the number of people who share their views. In modern environments we also see growing evidence of greater polarization. For example, according to the Pew Research Center over the past five decades, congressional US Democrat and Republican ideologies have increasingly diverged, with an ever shrinking middle ground. This is appears to also be reflected among US citizens, with a "disappearing center" hastened by growing “anarchist” and “anti-establishment” ideologies. Many have speculated that this polarization is a global phenomenon. The question we pose here is how beliefs and network structure might interact to facilitate both false consensus effects and rising polarization.
Is searching memory like searching space? William James once wrote that “We make search in our memory for a forgotten idea, just as we rummage our house for a lost object.” Both space and memory have structure and we can use that structure to zero in on what we are looking for. In searching space, this is easy to see. A person hunting for their lost keys is not unlike a starling scouring the garden for wayward insects. But in searching memory, what is the map? And by what means does a person move from one memory to the next? In this chapter I will lay out the similarities between foraging in space and mind and then describe a research approach inspired by an ecological model of animal forging. Using this approach, we will combine data from a memory production task with a cognitive map – a network representation – of memory derived from natural language. We will then use this to compare a suite of models aimed at teasing apart how memory search is similar to our garden starling.
Conspiracy theories explain anomalous events as the outcome of secret plots by small groups of people with malevolent aims. Is every conspiracy unique, or do they all share a common thread? That is, might conspiracy explanations stem from a higher-order belief that binds together a wide variety of overtly independent phenomena under a common umbrella? We can call this belief the conspiracy frame. Network science allows us to examine this frame at two different levels: by examining the structural coherence of individual conspiracies and by examining the higher-level interconnectivity of the conspiracy beliefs as a whole.
When nodes share features we can combine those features in many possible ways. One standard way is to base relationships on shared features. But there are other possibilities. Here we will apply a number of approaches to investigate the concept of distinctiveness. Distinctiveness is how easy it is to discriminate one thing from another thing. In an important sense distinctiveness is therefore a hypothesis about how the mind works. We say two things are distinctive because a mind can distinguish them. But what makes something distinctive? In this chapter, I will introduce some of the theory behind distinctiveness and then demonstrate how we can use network science to investigate distinctiveness in children’s abilities to learn words. This takes a multilayer network approach, in which we will examine many different edge types constructed of various combinations of shared and unshared features. By examining these edge types will discover how best to combine features and which feature combinations best predict early word learning.
Structure matters for understanding behavior. This chapters introduces the main theme of the book, provides a number of stories about the importance of structure, and outlines the main structure of the book.
Degree is the simplest of the node-level measures, but its simplicity often hides its power. Here we will apply degree to the problem of mental structure. Specifically, what is the structure of the relationships between information in the mind? George Kingsley Zipf observed that word frequencies in natural language tend to a follow a scale-free distribution: The most frequent words are few, while the less frequent words are many with a specific linear relationship on a log-log plot. It has also been suggested that this power-law distribution applies to the relationships between words as well as to their meanings. Some words share meanings with many other words while others share few. This is a hypothesis based on the structural distribution of shared meanings, or polysemy (words with multiple meanings). This chapter will explain the theory underlying Zipf’s law of meaning and power laws. It will also show how we can combine these ideas with the most basic node-level network measure: degree.