Governments are the most frequent interveners at the Supreme Court of Canada (SCC). However, we know little about government interventions, with the last substantive study only providing coverage of Charter cases up to 2007. To update this body of research, we provide an analysis of government interventions across all constitutional cases decided by the SCC between 2013 and 2023. Building upon earlier work by Hennigar (2010) and Radmilovic (2013), our study shows that despite changes to the intervener landscape in the past decade, governments continue to primarily intervene defensively in Charter cases. Importantly, however, our findings reveal complexity in how governments intervene across various constitutional cases, with distinct intervening behaviour in division of power disputes and reference cases.

The integration of wearable smart garments with multiple sensors has gained momentum, enabling real-time monitoring of users’ vital parameters across various domains. This study presents the development and validation of an instrumented smart shirt for risk prevention in workplaces designed to enhance worker safety and well-being in occupational settings. The proposed smart shirt is equipped with sensors for collecting electrocardiogram, respiratory waveform, and acceleration data, with signal conditioning electronics and Bluetooth transmission to the mobile application. The mobile application sends the data to the cloud platform for subsequent Preventive Risk Index (PRI) extraction. The proposed SenseRisc system was validated with eight healthy participants during the execution of different physically exerting activities to assess the capability of the system to capture physiological parameters and estimate the PRI of the worker, and user subjective perception of the instrumented intelligent shirt.

Objectives/Goals: Ischemic stroke treatments assist in restoring blood flow, but do not guarantee good outcomes. Since extracellular vesicles (EVs) able to cross the blood brain barrier, total (nonspecific) and astrocyte enriched EVs (TEVs, AEVs, respectively) from plasma may emerge as plasma biomarkers for prognostication and targeted therapeutics. Methods/Study Population: “Blood and Clot Thrombectomy Registry and Collaboration” (BACTRAC; NCT03153683) is a human stroke biobank at the University of Kentucky that collects samples at the time of mechanical thrombectomy during emergent large vessel occlusions (ELVO; ischemic stroke). EVs were isolated, via size exclusion chromatography, from unbanked plasma and concentrated resulting in TEVs. AEVs were immunoprecipitated with anti-EAAT1 (GLAST), an astrocyte-specific transmembrane glycoprotein. Isolated protein was sent to Olink and ran on their metabolic panel. Demographics and medical histories of the subjects were exported from REDcap and investigators were blinded during EV analysis. Results/Anticipated Results: ELVO subjects (8 females/ 5 males) were an average age of 71.1 ± 11.7 years. Lower TEV enolase 2, a neuronal glycolysis enzyme, associated with increased stroke severity (NIHSS; rs =  -0.7819, p = 0.0476). Higher systemically TEV quinoid dihydropteridine reductase (QDPR), essential co-factor enzyme, was associated with more severe strokes (NIHSS; rs =  0.8486, p = 0.0123) and lower cognition (MoCA; r2 =  0.7515, p = 0.0254). Interestingly, higher intracranial AEVs QDPR was associated with lower infarct volumes (rs =  -0.7333, p = 0.0202), less severe strokes (NIHSS; rs =  -0.6095, p = 0.0388), and better cognition (MoCA; r2 =  0.6095, p = 0.0388). Increased AEV nicotinamide adenine dinucleotide kinase another essential co-factor enzyme, intracranially also correlated to higher cognition (MoCA; rs =  0.8356, p = 0.0298). Discussion/Significance of Impact: Plasma TEV and AEV metabolic proteins correlate with the progression of stroke outcomes and should be investigated as target therapies during MT to improve outcomes.

Maladaptive daydreaming is a distinct syndrome in which the main symptom is excessive vivid fantasising that causes clinically significant distress and functional impairment in academic, vocational and social domains. Unlike normal daydreaming, maladaptive daydreaming is persistent, compulsive and detrimental to one’s life. It involves detachment from reality in favour of intense emotional engagement with alternative realities and often includes specific features such as psychomotor stereotypies (e.g. pacing in circles, jumping or shaking one’s hands), mouthing dialogues, facial gestures or enacting fantasy events. Comorbidity is common, but existing disorders do not account for the phenomenology of the symptoms. Whereas non-specific therapy is ineffective, targeted treatment seems promising. Thus, we propose that maladaptive daydreaming be considered a formal syndrome in psychiatric taxonomies, positioned within the dissociative disorders category. Maladaptive daydreaming satisfactorily meets criteria for conceptualisation as a psychiatric syndrome, including reliable discrimination from other disorders and solid interrater agreement. It involves significant dissociative aspects, such as disconnection from perception, behaviour and sense of self, and has some commonalities with but is not subsumed under existing dissociative disorders. Formal recognition of maladaptive daydreaming as a dissociative disorder will encourage awareness of a growing problem and spur theoretical, research and clinical developments.

This article defines and explores the concept of ‘resistance’ as a source of musical meaning in performance. Using Pierre Bourdieu's concept of ‘habitus’ as a framework, I examine my musical habitus: the embodied, internalised ways I play my instrument and think about music, which reflect my extensive musical histories and the fields in which these histories have taken place. Resistance arises in practice when this habitus is undermined. When the types of musicking undertaken circumvent my habituated understanding of acceptable performance and performative roles, it manifests as a pull towards more familiar modes of musical engagement. Making specific reference to resistance experienced in the development and performance of Alex Harker's Drift Shadow (2021), for solo oboe and electronics, the article outlines the ways in which my subjective relationship to my instrument and my role as a performer produce particular understandings of a work that can then nuance the way I play the piece.

Global Navigation Satellite System (GNSS) observations and ground-based timelapse photography obtained over the record-high 2019/2020 melt season are combined to characterise the flexure and fracture behaviour of a previously formed doline on George VI Ice Shelf, Antarctica. The GNSS timeseries shows a downward vertical displacement of the doline centre with respect to the doline rim of ~60 cm in response to loading from a central meltwater lake. The GNSS data also show a tens-of-days episode of rapid-onset, exponentially decaying horizontal displacement, where the horizontal distance between the doline rim and its centre increases by ~70 cm. We interpret this event as the initiation and/or widening of a fracture, aided by stress perturbations associated with meltwater loading in the doline basin. Viscous flexure modelling indicates that the meltwater loading generates tensile surface stresses exceeding 75 kPa. This, together with our timelapse photos of circular fractures around the doline, suggests the first such documentation of meltwater-loading-induced ‘ring fracture’ formation on an ice shelf, equivalent to the fracture type proposed as part of the chain-reaction lake drainage process involved in the 2002 breakup of the Larsen B Ice Shelf.