Asylum seekers face significant mental health challenges but underutilise mental health services and are at increased risk of misdiagnosis. The Cultural Formulation Interview (CFI) could be helpful by introducing individuals’ culture and context to psychiatric evaluation. However, its impact on the diagnostic process for asylum seekers remains underexplored.

This study aims to evaluate the added value of the CFI in the psychiatric diagnostic assessment of asylum seekers.

A mixed-methods design was applied. Diagnostic shifts from the CFI were quantitatively described in 63 participating asylum seekers. The CFI’s value was explored using qualitative content analysis.

In about a third of cases, diagnoses were either confirmed (34.9%), changed (25.4%) or narrowed (33.3%), with notable shifts from depressive and psychotic disorders to either trauma- and stressor-related disorders or no psychopathology. Qualitative analysis revealed that the CFI enhanced understanding of participants’ experiences, including the impact of trauma, migration and social context. It provided insights into their strengths and therapeutic needs. The shift towards stress-related diagnoses and away from other common DSM categories reflects the CFI’s ability to provide a more nuanced, contextual understanding of asylum seekers’ mental health.

This study underscored the CFI as a valuable tool in asylum seekers’ diagnostic assessment. The CFI facilitated a shift towards a more holistic, recovery-oriented approach. It prompted conceptual reflections on psychopathology in asylum seekers. The CFI presents a promising yet underutilised tool for addressing diagnostic challenges in cross-cultural settings. The findings highlight its potential for broader clinical implementation.

Asylum seekers have difficulty gaining access to mental healthcare. Lack of understanding of asylum seekers’ mental illness explanatory models appears to be an important barrier. Gaining a better understanding of these explanatory models is crucial for ensuring the inclusion of asylum seekers in healthcare services. The Cultural Formulation Interview (CFI) might help to explore asylum seekers’ explanatory models of mental illness.

To analyse asylum seekers’ explanatory models as elicited by the CFI.

The CFI and its first supplementary module were carried out with asylum seekers with mental health problems. Transcriptions of the interviews underwent reflexive thematic analysis within a social constructivist framework.

In the analysis of 25 illness narratives, three major themes characterising asylum seekers’ explanatory models were identified: a burden of the past, a disenabling current reality, and a personal position and individual experience.

The interplay among pre-, peri- and post-migration experiences, having a continuous impact on asylum seekers’ mental health, was highlighted by the themes ‘a burden of the past’, and ‘a disenabling current reality’. The theme ‘a personal position and individual experience’ revealed how the CFI enables self-determination in clinical encounters by embracing uncertainty and questioning the medicalisation of distress. The analysis characterises asylum seekers’ symptoms as a personal idiom of distress within socio-relational contexts. The CFI provides a clinically useful framework for exploring asylum seekers’ explanatory models and fostering dynamic understanding.