Between 2021 and 2023, the Center for Applied Isotope Studies (CAIS) tested over 500 samples for biobased carbon content under the United States Department of Agriculture’s (USDA) Biopreferred Program using the American Society for Testing and Materials (ASTM) biobased testing standard D6866. We describe some of the novel approaches we used to prepare a diverse array of biobased products and summarize those radiocarbon test results and success rates in meeting the USDA Minimum Biobased Content (MBC).