This article examines the experience of English Catholics within Spanish naval service during the Elizabethan period. It explores their status and roles, as well as the range of motives that led them into Spanish service—religious conviction, familial or military loyalties, the pursuit of fortune, or, in the case of prisoners, the necessity of survival. During the Anglo-Spanish War, the number of English sailors serving on Spanish vessels increased, driven in part by Spain’s demand for English navigational expertise and intelligence-gathering skills. Nonetheless, these mariners often faced mistrust and suspicion from their Spanish hosts, as well as financial hardship and the psychological strain. The article also demonstrates that English and Irish priests played a key role in aiding their adaptation and protection, while also drawing upon the mariners’ expertise to support clandestine operations and contribute to invasion plans aimed at the Catholic restoration of England.