The widespread use of atrazine in corn since the 1960s has raised environmental concerns, such as ground and surface water contamination. The U.S. Environmental Protection Agency has proposed label restrictions on atrazine to address these concerns and requires applicators to achieve herbicide mitigation points before applying herbicides. One way to achieve mitigation points is to reduce the proportion of the field that is treated. Therefore, research was conducted in 2023 in Arkansas, Mississippi, Tennessee, North Carolina, Indiana, and Virginia, and in 2024 in Arkansas, Tennessee, and Indiana, to determine whether targeted applications can mitigate atrazine use in corn while maintaining weed control levels comparable to those achieved with broadcast applications. All plots, except the nontreated control, received paraquat and S-metolachlor immediately after planting in 2023, with amicarbazone and metribuzin added in 2024. Combinations of atrazine, glyphosate, and mesotrione were applied postemergence either broadcast, target-applied to emerged weeds, or a combination of broadcast and target-applied. Targeted applications of herbicides did not differ in weed control, including Palmer amaranth and morningglory species, compared to broadcast applications of the same active ingredients. No injury or differences in corn grain yield were observed. Targeted applications in 2023 covered 86% of the area, on average, while 52% of the area was sprayed on average in 2024. Differences in the area sprayed during the targeted application between years can be attributed to the reduced area of weed emergence from a more robust residual herbicide combination in 2024. Based on this research, targeted spray technology can reduce atrazine use in corn while providing weed control comparable to that achieved with broadcast applications.