One factor that has been shown to mediate and protect against psychopathology is the ability to engage in meaning making in adverse situations during the COVID-19 pandemic. To date, the models that have attempted to explain the relationship between traumatic, stressful events’ meaning and clinical symptoms have been conducted in a piecemeal fashion. The objective of this study is to analyze which model (two-pathway model vs three-pathway model) has a better fit in explaining the association between the violation of global meaning and clinical symptoms such as somatization, anxiety, and depression in participants during the COVID-19 pandemic. The study sample consisted of N = 1106 adults. The results suggest that the violation of schemas affects depression and anxiety symptoms through three pathways: (a) Path one, directly, schema violation explains clinical symptoms; (b) Path two, indirectly, schema violation explains clinical symptoms through the search for meaning and negative effect; and (c) Path three, the presence of meaning explains positive affect and buffers clinical symptoms. The three-pathway model explains 90% of the variance in clinical symptoms. The three-pathway model has clinical implications for the assessment, prevention, and treatment of people who are coping with unforeseen negative situations.