The production, trade, and consumption of meat products and their movement around the planet were essential to the development of global markets during the first wave of globalization. This article analyzes the main changes in the ownership structure and profile of the beef industry in South America from the late nineteenth century until 1930 and how this process was reflected in certain macroeconomic variables. It provides a comprehensive analysis of the drivers of success of the meat-producing regions of Argentina, Uruguay, Brazil, Paraguay, and Patagonia (both the Argentine and Chilean sides), and also examined the failure cases of Venezuela and the Colombian Caribbean.