Scholars have long noted the prevalence of exile as a theme in John Calvin’s theology, which responded to times unsettled by religious persecution and migration. However, research has only begun to describe with precision how Calvin portrayed exile. This article examines the theme in Calvin’s biblical exegesis, demonstrating how his commentaries and sermons problematize exile by establishing two requirements for faithfulness from the exilic experiences of Abraham and David: 1) open confrontation with idolatry; and 2) the pursuit of sacramental nurture. In both cases, the reformer’s exegesis is notable for reflexively invoking Nicodemism, persistently deploying Abraham and David as counterexamples against this contemporary problem. This intersection of crypto-religion and exile, considered spiritually and politically, displays how context drove Calvin’s exegesis toward readings distinctive in the history of interpretation. It also sharpens exile’s polemical potential as a differentiated category Calvin used to encourage the community of believers while disciplining its behavior.