Scholars have long maintained that Irenaeus rejected the use of Hellenic resources in Christian theology. While recent decades have seen better recognition of Irenaeus’ philosophical and rhetorical knowledge, Irenaeus’ use of poetic literature, especially Homer, has received little attention. The present article rectifies this deficiency. First, it defines the role of Homeric material in Irenaeus’ broader theological project. Then, studying Irenaeus’ use of a unique Homeric word, proprocylindomene (Haer. 1.11.4), it demonstrates that Irenaeus appropriates Homer to his theological project with the facility that Quintilian associates with a practiced and skillful rhetorician. In light of this, the article concludes by contending that Irenaeus likely composed the Homeric cento in Haer. 1.9.4 himself. If this is the case, Haer. 1.9.4 constitutes perhaps Irenaeus’ most skillful appropriation of Homer to his theological project. It best illustrates how for Irenaeus the poet could be used in a Christian theological project.