The adaptive stabilization is investigated for a class of coupled PDE-ODE systems withmultiple uncertainties. The presence of the multiple uncertainties and the interactionbetween the sub-systems makes the systems to be considered more general andrepresentative, and moreover it may result in the ineffectiveness of the conventionalmethods on this topic. Motivated by the existing literature, an infinite-dimensionalbacksteppping transformation with new kernel functions is first introduced to change theoriginal system into a target system, from which the control design and performanceanalysis of the original system will become quite convenient. Then, by certaintyequivalence principle and Lyapunov method, an adaptive stabilizing controller issuccessfully constructed, which guarantees that all the closed-loop system states arebounded while the original system states converging to zero. A simulation example isprovided to validate the proposed method.