The transition to renewable energy and the urgent need to reduce greenhouse gas emissions highlight green hydrogen’s role in decarbonizing various sectors. To address the increasing demand, the research initiative H2Giga FertiRob focuses on automating the production of hydrogen electrolyzers, emphasizing PEM stack assembly. Existing stack designs are often incompatible with automation and hinder scalable production. This paper introduces an adapted Design for Automation approach for PEM stacks. Through the evaluation of a reference stack, key design limitations are identified, leading to the development of an optimized stack with reduced part diversity, improved handling, and enhanced automation compatibility. The methodology provides a systematic framework to advance the automated production of PEM stacks, supporting the scalability of green hydrogen in the global energy transition.