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Edited by
James Ip, Great Ormond Street Hospital for Children, London,Grant Stuart, Great Ormond Street Hospital for Children, London,Isabeau Walker, Great Ormond Street Hospital for Children, London,Ian James, Great Ormond Street Hospital for Children, London
Ophthalmic surgery takes place in children of all ages, from premature neonates to teenagers, the majority of whom are ASA 1 or 2. In some cases, the ocular pathology may be part of a wider congenital or metabolic abnormality and anaesthesia is not so straightforward. Nearly all will require general anaesthesia. Anxiety can be common in children returning for repeated procedures, and premedication may be necessary. Surgery can be extraocular or intraocular. Simple day-case procedures can usually be managed with an inhalational spontaneous breathing technique and supraglottic airway device (SAD). Certain more complex cases necessitate a completely still eye, and muscle relaxation is therefore usually required. Special anaesthetic considerations are management of the oculocardiac reflex (OCR), commonly elicited by traction on the recti muscles and prevention of postoperative nausea and vomiting (PONV); strabismus surgery is particularly emetogenic. The majority of ophthalmic surgery is not particularly painful, and simple analgesia with paracetamol and NSAIDs is sufficient. Regional ophthalmic blocks, such as sub-Tenons, can supplement or offer an alternative to opiates when additional analgesia is required. This has the added advantage of producing akinesis of the globe and a beneficial reduction in PONV and the OCR.
The pupil allows light to enter the human body. Without the pupil, the human brain would not have an accurate representation of the world. The structure of the eye next to and behind the pupil is described in this chapter. It will emphasize that the pupil is not actually an anatomical structure, but is formed by the arrangement of two muscle groups that embryologically are part of the brain.
Chapter 23 sets Goethe’s Farbenlehre (Theory of Colours) in context. Colour had been the subject of intensive study, both aesthetic and scientific, in the eighteenth century, and the chapter reconstructs the many influences on Goethe and his contemporaries, from the recent discoveries of Herschel and Ritter, to earlier figures, above all Newton, but even Aristotle and Hippocrates. The chapter also presents the central tenets of Goethe’s Farbenlehre, with a particular focus on the theoretical first part, which offers a physiological theory of colours and deals with the physical nature of light.
This chapter details the eye diseases (conjunctivitis, keratitis, retinitis and scleritis) caused by viruses and other organisms (adenoviruses, enteroviruses, HSV, measlesvirus, influenzaviruses, VZV, CMV, Toxoplasma gondii, molluscum contagiosum, papillomaviruses and HHV8). It details symptoms, epidemiology, diagnosis and treatment.
To compare the baseline signal between two conditions used to generate the photopic negative response (PhNR) of the full-field electroretinogram (ERG): red flash on a blue background (RoB) and white flash on a white background (LA3). The secondary purpose is to identify how the level of pre-stimulus signal affects obtaining an unambiguous PhNR component. A retrospective chart review was conducted on four cohorts of patients undergoing routine ERG testing. In each group, LA3 was recorded the same way while RoB was generated differently using various luminances of red and blue light. The background bioelectrical activity 30 ms before the flash was extracted, and the root mean square (RMS) of the signal was calculated and compared between RoB and LA3 using Wilcoxon test. Pre-stimulus noise was significantly higher under RoB stimulation versus LA3 in all four conditions for both right and left eyes (ratio RoB/LA3 RMS 1.70 and 1.57 respectively, p < 0.033). There was also no significant difference between the RMS of either LA3 or RoB across protocols, indicating that the baseline noise across cohorts were comparable. Additionally, pre-stimulus noise was higher in signals where PhNR was not clearly identifiable as an ERG component versus signals with the presence of unambiguous PhNR component under RoB in all four groups for both eyes (p < 0.05), whereas the difference under LA3 was less pronounced. Our study suggests that LA3 produces less background bioelectrical activity, likely due to decreased facial muscle activity. As it seems that the pre-stimulus signal level affects PhNR recordability, LA3 may also produce a better-quality signal compared to RoB. Therefore, until conditions for a comparable bioelectrical activity under RoB are established, we believe that LA3 should be considered at least as a supplementary method to evaluate retinal ganglion cell function by ERG.
Chapter 19 investigates the conceptual mappings of conventional figurative expressions, specifically idioms and collocations containing the body-part term nwun “eye(s)” in Korean. Working within the framework of conceptual metaphor theory (Lakoff and Johnson 1980), the study explores the types of conceptual shift that give rise to extended meanings and discusses how extension mechanisms draw on shared features between source and target domains. Common Korean expressions involving the eyes involve vision, persons, time, events/processes, perception (e.g., attention, attraction, interest, judgment), mind activities (e.g., thinking, knowing, understanding), and emotions (e.g., anger, avarice, surprise). These figurative expressions are motivated by the basic experiences of eye behavior, eye appearance, and vision, as well as by our interactions with people and environments. The findings of this study contribute to our understanding of the influence of embodiment in language in general and in Korean in particular.
Decreased vision in the aged population poses significant morbidity and decreases quality of life. At least one third of the American population over age 65 has significant vision compromise due to ophthalmic disease. Decreased vision limits independence and poses significant economic and societal burdens. Ophthalmic disease in the elderly poses significant challenges to patients and providers due to the vast and diverse spectrum of ophthalmic conditions, and therefore requires specialized care by optometrists and ophthalmologists.
Ophthalmic diseases are seen at a higher frequency in aged patients and include structural changes, malignancies, and infections of the eyelids and orbit. In addition, diseases such as cataracts, age-related macular degeneration (ARMD), glaucoma, and ischemic optic neuropathy are seen at a significantly higher incidence in elderly patients and can result in severe vision loss. Routine ophthalmic care is required to identify, manage, and treat such diseases in order to prevent sequelae, optimize independence, and preserve vision. Medical therapies, surgical intervention, low-vision aids, and social support systems can be utilized to aid in treatment.
This study aimed to characterize ophthalmology consultations ordered after Hurricane Harvey compared to consultations ordered during the same time period of the prior year.
Methods:
A retrospective chart review was performed at an urban, level 1 trauma center of a county hospital. All patients were included who received an electronic health record, documented ophthalmology consultation order between September 2017 and October 2017 (the time period immediately following Hurricane Harvey) or September 2016 and October 2016. Patient demographic risk factors were collected. Patient ICD10 clinical diagnoses were categorized as extraocular, intraocular, infectious, physiological, or other, and then subcategorized as trauma or non-trauma-related. A geographical heat map was generated to compare the changes in diagnosis volume by zip code to the magnitude of rainfall in the county.
Results:
Following Hurricane Harvey, ophthalmology consultation volume decreased, number of infectious ophthalmology diagnoses increased (P < 0.001), percentage of patients on immunosuppression increased (P < 0.001), and the number of private insurance payers increased while the number of county-funded insurance payers decreased (P = 0.003).
Conclusions:
The risk of infectious eye diagnosis was double the risk of traumatic eye diagnosis from Hurricane Harvey flooding. During public disaster planning, different ophthalmological medical resources and responses should be considered for flooding versus high-wind events.
The abnormal animal featured here is a frog with its eyes in its mouth. In order to explain how it got that way, the chapter describes how retinas induce lenses. That leads to a discussion of induction in general and to a consideration of the overall strategies that animals use to build their anatomy.
The second chapter studies the efforts of the Christian Ḥunayn ibn Isḥāq, whose workshop in ʿAbbāsid Baghdad translated the Galenic sources considered in this book, to enhance the respectability of the specialism of ophthalmology in his Ten Treatises on the Eye. I show that, even more so than medicine, ophthalmology was at a disadvantage in its pursuit for epistemic authority because Galen himself had attacked the sub-field as an exemplar of the worrying tendency among doctors in Rome and other cities towards specialization, which threatened the unity of the discipline and the health of patients. Concerned with his own intellectual status at court, Ḥunayn, I argue, subversively uses Galen's explanation of the Timaeus' description of the eyes' service to the rational soul to give ophthalmologists a stake in medico-philosophical controversies relating to sensation. I also expose how Ḥunayn modifies Galen’s interpretation of Plato’s teleological ocular anatomy and visual theory in order to privilege the eye over all other organs as a window to cosmic knowledge.
Age-related changes affect all structures of the eye, and while age-related changes may influence the quality of vision, it is important to distinguish age-related physiological changes from pathological changes. This is important particularly when identifying pathological changes that may be treatable. The prevalence of visual loss increases substantially after 60 years of age and poor vision is the second most prevalent physical disability in older people. This review describes the normal ageing changes of the eye and outlines common ophthalmic diseases affecting older people. We refer to recent advances in diagnosis and treatment, and relevant current research.
To discuss the minimally invasive treatment and prognosis of juvenile nasopharyngeal angiofibroma involving the eye and optic nerve.
Methods:
Retrospective analysis of clinical data for 18 large juvenile nasopharyngeal angiofibromas, with reports of three typical cases.
Results:
The tumour invaded the orbit, eye, optic nerve and optic chiasm in 18, 9, 8 and 5 patients, respectively. Twelve patients were cured after surgery, with the affected eye and vision essentially returning to normal. In six patients, tumour residue was found in the middle cranial fossa; two of these six did not return for follow up. Four patients underwent radiotherapy; all four regained placement of the eye in a normal or near-normal position. One of these four patients regained normal visual acuity, two experienced no improvement in visual acuity, and one became blind.
Conclusion:
In patients with this tumour, surgery may return the eye to the normal position and may restore visual acuity if the optic fundus, macula, retina and optic nerve are only mildly affected. Modern radiotherapy can treat the intracranial residue effectively. A combined approach via the antrum, infratemporal fossa and nasal cavity, using a Caldwell–Luc incision, provides minimally invasive surgical access.
Studies have reported that refractive errors are associated with premature births. As twins have higher prevalence of prematurity than singletons, it is important to assess similarity of the prevalence of refractive errors in twins and singletons for proper interpretations and generalizations of the findings from twin studies. We compared refractive errors and diopter hours between 561 pairs of twins and 3757 singletons who are representative of school-age children (7–15 years) residing in an urban area of southern China. We found that the means and variances of the continuous measurement of spherical equivalent refractive error and diopter hours were not significantly different between twins and singletons. Although the prevalence of myopia was comparable between twins and singletons, that of hyperopia and astigmatism was slightly but significantly higher in twins than in singletons. These results are inconsistent with those of adult studies that showed no differences in refractive errors between twins and singletons. Given that the sample size of twins is relatively small and that this study is the first to demonstrate minor differences in refractive errors between twins and singletons, future replications are necessary to determine whether the slightly higher prevalence of refractive errors in twins than in singletons found in this study was due to a sampling error or to the developmental delay often observed in twins in childhood.
A metastrongyle worm extracted from the anterior chamber of the right eye of a patient in Sri Lanka belongs to the genus Parastrongylus and probably to a yet undescribed species, related to P. cantonensis well known to infect man. It is mostly a parasite of rodents, wandering in man and unadapted to this host. Evidence for this lack of adaptation are that the specimen is undergoing necrosis (teratological specimen) and is located in an organ with little immunological defences.
Ultrasound has long been an integral part of the ophthalmologist's examination of the eye and orbit. The use of ocular ultrasound was first published in 1956 and has since come to be used extensively with A-scan, B-scan, Doppler, and, more recently, 3D approaches. Both axial and longitudinal approaches are commonly employed in ED ultrasound of the eye and orbit. Due to the emphasis on recognition of acute life-threatening conditions in the ED, the application of ocular ultrasound most widely studied in the emergency medicine literature is in the evaluation of increased intracranial pressure by evaluation of optic nerve sheath diameter. Ultrasound easily allows identification of lens dislocation, vitreous hemorrhage, and globe rupture, among other traumatic conditions. ED ultrasound may also prove to be useful in the evaluation of optic neuritis. Ocular ultrasound is a relatively new ED imaging modality that is rapidly gaining acceptance among emergency clinicians.
A 33-year-old woman presented to a community emergency department with a 4-day history of monocular orbital pain, photophobia and pain on extraocular movement. Findings included chemosis, conjunctival injection and restricted extraocular movements causing strabismus. She was diagnosed with orbital cellulitis during her initial emergency department visit and treated with intravenous antibiotics. On her second ED visit later the same day, a diagnosis of orbital pseudotumour was made after computed tomography revealed inflammation of the sclera, optic nerve, muscle and adipose tissue within the orbit. Antibiotics were discontinued and tapering steroids were initiated, with prompt resolution of symptoms.