We report the heterogeneous integration of a multifunctional sensor based onpolymer porous photonic bandgap (P3BG) structure and xerogelbased luminescence sensor technology. The P3BG structure wasfabricated using holographic interferometry. Initially, holographicinterferometry of a photo-activated prepolymer syrup that included avolatile solvent as well as monomer, photoinitiator, and co-initiator wasused to initiate photopolymerization. Subsequent UV curing resulted in welldefined lamellae of the polymer separated by porous polymer regions thatcreated a high quality photonic bandgap structure. The resulting P3BG structure was then integrated with the xerogel basedluminescence element to produce a luminescence sensor with a selectivenarrow band reflector. The prototype xerogel based luminescence sensorelement consisted of an O2 sensing material based on spin coatedtetraethylorthosilane (TEOS) composite xerogel films containing tris(4,7-diphenyl-1,10-phenanthroline) ruthenium (II) ([Ru(dpp)3]2+) luminophore. We demonstratedenhancement of the signal-to-noise ratio (SNR) of this integratedmultifunctional sensor while maintaining the same sensitivity to O2 sensing of the xerogel based element. The resultingadvantages and enhanced SNR of this integrated sensor will provide atemplate for other luminescence based assays to support highly sensitive andcost-effective sensor systems for biomedical applications.