Turnover intention constitutes a challenge for organizations. Meaningful work and employee engagement can reduce turnover intention, but their relationship is complex. This study aims to understand how meaningful work, work and organizational engagement, and turnover intention interact with each other. Using a structural equation model with data from 562 employees, meaningful work was examined as the independent variable, turnover intention as the dependent variable, and work and organizational engagement as serial mediators. Results show that work engagement partially mediates the relationship between meaningful work and organizational engagement, and organizational engagement partially mediates the link between work engagement and turnover intention. Additionally, a serial mediation effect of work and organizational engagement on the relationship between meaningful work and turnover intention was confirmed. Therefore, we encourage organizations to provide meaningfulness to their employees’ jobs and engage them within their job and organization not only to promote retention, but also to develop an engaged, healthy and sustainable workforce that supports both organizational sustainability and general societal well-being.